CAS: 462-10-2; 4,4'-Disulfanediylbis(2-Aminobutanoic Acid)

相似化合物

6027-15-2 626-72-2 113132-85-7

上下游产品

CAS号1017-76-1 s-benzyl-dl-hom... | CAS号10593-85-8 (S)-3-AMINODIHY... | CAS号454-29-5 DL-高半胱氨酸 | CAS号504-33-6 DL-高磺基丙氨酸 | CAS号123-41-1 胆碱 | CAS号62-49-7 胆碱 | CAS号60175-95-3 奥莫司坦

Dl-高半胱氨酸置于高氯酸,Sodium Perchlorate,Fac-[pt(Dach)Cl3(oc(=o)Ch3)].35Hcl,Sodium Chloride体系中,用 水 作为反应溶剂,化学反应 0.08H,反应生成 L-高胱氨酸
参考文献:生物硫醇化合物还原不对称 Pt(Iv) 前药 Fac-[pt(Dach)Cl3(oc(=o)Ch3)]:动力学和机械特性
标题:生物硫醇化合物还原不对称 Pt(Iv) 前药 Fac-[pt(Dach)Cl3(oc(=o)Ch3)]:动力学和机械特性
摘要:合成了不对称 Pt(Iv) 前药fac-[pt (Dach)Cl 3 (oc(=o)Ch 3)] (Dach = 1,2-二氨基环己烷),并将 Pt(Iv) 前药还原了三个生物硫醇谷胱甘肽 (Gsh),半胱氨酸 (Cys) 和同型半胱氨酸 (Hcy) 通过停流光谱仪进行研究.所有还原之后是整体二级反应,在 [pt(Iv)] 和 [硫醇] 中均发生一级反应.pt(Iv) 前药的还原通过氯桥 (Pt-Cl-S) 介导的两个电子转移过程发生.因此,配位的氯化物比来自pt(Iv) 前药的配位-Ch 3 Coo-的氧原子具有更好的架桥效应.k' Cys的反应趋势 > K' Gsh > K' Hcy被发现,说明在 Ph 7.4 缓冲液中反应性遵循 Cys > Gsh > Hcy 的趋势. 图形概要 过渡态在铂 (Iv) 络合物的轴向配位氯化物与来自 Cys/hcy/gsh 的硫醇/硫醇盐基团的硫原子之间形成.
DOI:10.1007/s11243-021-00480-6

专利信息

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-6225341-B1
优先权日:1995-02-27
标 题:Compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A
权利人:GILEAD SCIENCES INC
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:US-9469850-B2
优先权日:2007-01-18
标 题 :Oligosaccharides comprising an aminooxy group and conjugates thereof
发明人：ZHU YUNXIANG; CHENG SENG H; JIANG CANWEN; AVILA LUIS Z
权利人:GENZYME CORP
摘要:The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy group to glycoproteins, and oligosaccharide-protein conjugates. Also provided are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-protein conjugate.