CAS: 460-00-4; 1-Bromo-4-Fluorobenzene

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CAS号106-40-1 对溴苯胺 | CAS号462-06-6 氟苯 | CAS号5467-74-3 4-溴苯硼酸 | CAS号106-41-2 对溴苯酚 | CAS号106-37-6 对二溴苯 | CAS号459-45-0 Benzenediazoniu... | CAS号1765-93-1 4-氟苯硼酸 | CAS号101419-76-5 2-(4-氟苯基)-3-甲基吡啶 | CAS号106516-54-5 5-chloro-3-[1-(... | CAS号10540-41-7 4'-Fluoro-3-bip... | CAS号398-23-2 4,4'-二氟联苯 | CAS号10540-43-9 1-fluoro-4-(3-m... | CAS号10540-33-7 3-(4-fluorophen... | CAS号106203-25-2 2-(4-fluorophen... | CAS号455-15-2 4-氟苯基甲基砜 | CAS号330-84-7 4-氟联苯醚 | CAS号456-03-1 4'-氟苯丙酮

4-氟苯硼酸置于sodium Nitrite体系中,用 乙腈 作为反应溶剂,化学反应 1.0H,以90%的收率获得产物对溴氟苯
参考文献:聚-N-溴磺酰胺-三聚氰胺作为一种新型溴化试剂用于芳基硼酸的区域选择性同溴化
标题:聚-N-溴磺酰胺-三聚氰胺作为一种新型溴化试剂用于芳基硼酸的区域选择性同溴化
摘要:在聚-N-溴磺酰胺-三聚氰胺(Pbbsm)存在下,通过硼酸的区域选择性溴化,开发了一种合成芳基溴的实用合成方法.在这方面,已成功合成了一种新型多相载体,即交联聚磺酰胺-三聚氰胺,以稳定具有高表面官能团密度(6.6 Mmol Br + /g)的溴.所制备的试剂是一种新型溴化试剂,它结合了n-溴磺酰胺,N-溴磺酰胺-三聚氰胺和三聚氰胺基团的有效功能.使用 Xrd,Ft-Ir,1 H NMR,Tga,Fe-Sem,Edx 和 Tga 分析表征 Pbbsm 的结构. 图形摘要
DOI:10.1007/s00706-021-02827-2

专利信息

专利号:US-2025179012-A1
优先权日:2022-03-04
标 题:Synthesis of sulfur(vi) compounds and reagents for same
发明人：LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

专利号:US-7276637-B2
优先权日:2002-08-02
标题:Synthesis of cyclohexanone derivatives
发明人：BRANDS KAREL MARIE JOSEPH; DAVIES ANTONY JOHN; OAKLEY PAUL JOSEPH; SCOTT JEREMY PETER; SHAW DUNCAN EDWARD; TEALL MARTIN RICHARD
权利人:MERCK & CO INC
摘要:A novel process for preparing cyclohexanone derivatives of formula (I) n nis described. The products are useful as gamma secretase inhibitors, or as intermediates in the synthesis of other gamma secretase inhibitors.

专利号:US-2008119662-A1
优先权日:2004-02-16
标 题:One Spot Synthesis of Citalopram from 5-Cyanophthalide
发明人：NARAHARI BABU AMBATI; SRINIVAS GOUD VUDDAMARI; GAONKAR SANTOSH LAXMAN; MANJUNATHA SULUR G; KULKARNI ASHOK KRISHNA; KULKARNI MADHARI A
权利人:JUBILANT ORGANOSYS LIMTED
摘要:A process for one pot synthesis of citalopram is disclosed. The process comprises subjecting 5-cyano phthalide to Grignard reduction followed cyclization and followed by C-alkylation reaction to obtain citalopram without isolation and purification of any intermediates. In another embodiment, 5-cyano phthalide is subjected to sequential Grignard reactions followed by cyclization to obtain citalopram without isolation and purification of any intermediate stages.

专利号:US-2015336866-A1
优先权日:2013-01-01
标题:Synthesis of difluoromethyl ethers and sulfides
发明人：HARTWIG JOHN; FIER PATRICK
权利人:UNIV CALIFORNIA
摘要:The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone-depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.

专利号:EP-2918579-A1
优先权日:2014-03-14
标题 :Synthesis of 2-arylmethyl-5-aryl-thiophene
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides a new synthetic process for the production of 2-arylmethyl-5-aryl-thiophene, an intermediate in the synthesis of C-aryl glycosides.

专利号:US-6600040-B2
优先权日:2000-06-08
标 题:Process for the synthesis of (2R, 2-alpha-R, 3A)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1, 4-oxazine
发明人：BRANDS KAREL M JOS; TSAY FUH-RONG; CONRAD KAREN M; ZHAO MATTHEW M
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R, 3a)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-3-(4-fluorophenyl)-1,4-oxazine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.