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CAS号67-63-0 异丙醇 | CAS号99-96-7 4-羟基苯甲酸 | CAS号4541-32-6 2,2-二甲基环戊酮 | CAS号37470-70-5 isopropyl 4-hyd... | CAS号99-76-3 尼泊金甲酯 | CAS号555-31-7 异丙醇铝 | CAS号24262-66-6 4-乙酰氧基苯甲酸甲酯 | CAS号13031-45-3 ethyl 4-acetylo... | CAS号54835-09-5 benzyl 4-acetox... | CAS号27739-13-5 propyl 4-acetyl... | CAS号13205-46-4 4-异丙氧基苯甲酸

苯酚置于盐酸,Aluminum (Iii) Chloride,1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 四氢呋喃,氯苯 作为反应溶剂,化学反应 52.0H,反应生成 尼泊金异丙酯
参考文献:使用 Houben-Hoesch 反应从富含同位素的酚中合成 13C 标记的对羟基苯甲酸酯
标题:使用 Houben-Hoesch 反应从富含同位素的酚中合成 13C 标记的对羟基苯甲酸酯
摘要:对羟基苯甲酸酯是多种消费品中的抗菌添加剂.然而,在废水消毒过程中由对羟基苯甲酸酯形成的卤代化合物是一个潜在的环境问题.为了识别这些转化产物并研究它们的形成机制,开发了一种在苯环内特定位置用稳定同位素碳 13 标记对羟基苯甲酸乙酯的合成路线.这种有效的两步法从市售的13 C 标记的苯酚开始,包括 (1) 通过与三氯乙腈的 Houben-Hoesch 反应对苯酚进行初始酰化,然后 (2) 对所得三氯甲基酮进行改进的卤仿反应,得到对应13C 标记的对羟基苯甲酸乙酯的总产率为 65%-80%.还研究了改进的卤仿反应的范围,允许合成衍生自伯醇或仲醇的其他对羟基苯甲酸酯,包括13 C-和氘标记的酯.此外,4-羟基苯甲酸可以直接由常见的三氯甲基酮中间体在用氢氧化锂处理后形成.该方案补充了现有的制备13 C 标记的对羟基苯甲酸酯衍生物的方法,并提供了在 Houben-Hoesch 反应(形成对二取代产物)
DOI:10.1002/jlcr.3992

专利信息

专利号:US-10768157-B2
优先权日:2015-10-20
标 题:Materials and methods for the detection of trace amounts of substances in biological and environmental samples
发明人：KABIR ABUZAR; FURTON KENNETH G
权利人:KABIR ABUZAR; FURTON KENNETH G; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.

专利号:US-8450456-B2
优先权日:2007-12-21
标题:Activating peptide of the synthesis of aquaporins and cosmetic and/or pharmaceutical composition containing it
发明人：DAL FARRA CLAUDE; DOMLOGE NOUHA; BOTTO JEAN-MARIE
权利人:DAL FARRA CLAUDE; DOMLOGE NOUHA; BOTTO JEAN-MARIE; ISP INVESTMENTS INC
摘要:The present invention concerns a peptide of the general formula (I): n R 1 -(AA) n -X 1 —X 2 —X 3 -Pro-X 4 —X 5 —X 7 -(AA) p -R 2 , capable of activating the synthesis of proteins of the family of aquaporins. n The present invention also concerns a cosmetic, nutraceutical or pharmaceutical composition, comprising a peptide of general formula (I) as active principle. The invention also relates to the use of this new active principle in a cosmetic or nutraceutical composition, intended to improve the moisturizing and the barrier function of the epidermis and intended to stimulate cutaneous regeneration. The invention also relates to the use of this new active principle to realize a pharmaceutical composition, and in particular a dermatological composition, intended to regulate and/or stimulate the activity of the aquaporins and to thus treat the pathological dryness of the skin or mucosa. The invention also relates to a method of cosmetic treatment intended to prevent or combat against dryness of the skin and mucosa, and the manifestations of cutaneous ageing.

专利号:US-8431523-B2
优先权日:2006-06-01
标题:Oligomeric biosurfactants in dermatocosmetic compositions
发明人：OWEN DONALD R; FAN LILI
权利人:OWEN DONALD R; FAN LILI
摘要:Oligomeric acylated biosurfactants (“OABsâ€?) having low critical micelle concentrations of from about 1.0 ppm to about 200 ppm, preferably less than about 50 ppm, in an aqueous solution of Minimal Essential Media that can lower the surface tension in the aqueous MEM environment to less than about 50 dynes/cm 2 and have the ability to increase metabolic soluble proteins and/or increase synthesis of extracellular skin matrix proteins and/or increase rates of cell turnover while at the same time exhibiting comparatively low toxicity—preferably, an LD 50 of greater 200 ppm in 37 year-old female fibroblast cells. Another aspect of the present invention is directed to the use of OABs in formulations that are topically-applied, by which is meant the formulation is placed in direct contact with the skin, hair and nails as well as mucosa of the eyes, ears, nose, mouth, anus and vagina.

专利号:ES-2435576-T3
优先权日:2007-12-21
标 题 :Peptide to activate the synthesis of aquaporins

专利号:CA-2640585-A1
优先权日:2003-02-05
标题 :Synthesis of 2-butyl-3-(2'-(1-trityl-1h-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspirol{4,4}-non-ene-4-one

专利号:CN-111635364-A
优先权日:2020-06-16
标 题 :Proline ionic liquid and synthesis of catalytic nipagin ester by using same