CAS: 40186-70-7; 2,2',3,3',4,5',6-Heptachlorobiphenyl

该化合物是多氯代联苯(PCB)家族的成员,该家族由多氯代苯双联分子组成,该化合物的特点是联苯结构附带7个氯原子,有助于其化学稳定性和水分缺乏性.七氯联苯的特点是其分子重量高,波动性低,使其在环境中具有持久性.它通常在室温中被发现为固体,在水中无法溶解,但在有机溶剂中可溶解.由于其氯化结构,它表现出对降解的强烈抗药性,导致食物链中的生物累积性.该化合物与各种环境和健康关切有关,包括潜在的毒性和内分泌干扰.许多国家都实施了管制措施,以限制其使用和释放到环境中,反映多氯联苯的更广泛问题及其对生态系统和人类健康的影响.

英文名称2,2',3,3',4,5',6-Heptachlorobiphenyl
中文名称2,2',3,3',4,5',6-七氯联苯
IUPAC名称1,2,3,5-tetrachloro-4-(2,3,5-trichlorophenyl)benzene
其它别名2,2',3,3',4,5',6-Heptachlorobiphenyl
CAS编号40186-70-7
MFCD编号:MFCD00792628
FDA UNII编号:5C2I5Q45X2
分子式:C12H3Cl7分子量:395.32
产品CID: 1414540
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
InChIKey: KJBDZJFSYQUNJT-UHFFFAOYSA-N
1S/C12H3Cl7/c13-4-1-5(10(17)7(15)2-4)9-6(14)3-8(16)11(18)12(9)19/h1-3H
计算化学: 氢键受体数*氢键供体数*可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

2,3,4,6-tetrachloroaniline 1,2,4-Trichlorobenzene

合成工艺路线路线简述

📜2,3,4,6-四氯苯胺,三氯苯置于亚硝酸异戊酯体系中,化学反应生成 2,2',3,3',4,5',6-七氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4