CAS: 39115-96-3; 3-Bromobenzhydrazide

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CAS号24398-88-7 3-溴苯甲酸乙酯 | CAS号618-89-3 3-溴苯甲酸甲酯 | CAS号585-76-2 3-溴苯甲酸 | CAS号1711-09-7 3-溴苯甲酰氯 | CAS号3132-99-8 间溴苯甲醛 | CAS号41491-53-6 2-(3-溴苯基)-5-甲基-... | CAS号873090-18-7 5-(3-溴苯基)-1,3,4... | CAS号618-89-3 3-溴苯甲酸甲酯 | CAS号73713-56-1 Benzoic acid, 3... | CAS号84196-25-8 2'-(3-bromobenz... | CAS号383130-99-2 5-(3-溴苯基)-4H-1,...

📜间溴苯甲酸置于硫酸,肼体系中,用 甲醇 用作溶剂,化学反应生成3-溴苄肼
参考文献:探索绕丹宁连接的烯胺-碳酰肼衍生物作为分枝杆菌碳酸酐酶抑制剂:设计,合成,生物学评价和分子对接研究
标题:探索绕丹宁连接的烯胺-碳酰肼衍生物作为分枝杆菌碳酸酐酶抑制剂:设计,合成,生物学评价和分子对接研究
摘要:随着耐多药结核病的兴起,寻找一种结合新作用机制的替代性优质治疗方案变得至关重要.为了实现这一目标,我们开发并合成了一系列新的绕丹宁连接的烯胺碳酰肼衍生物,探索它们作为分枝杆菌碳酸酐酶抑制剂的潜力.研究结果揭示了它们的功效,对分枝杆菌碳酸酐酶 2 (Mtca 2) 酶表现出显着的选择性.该系列化合物虽然对人碳酸酐酶异构体表现出中等活性,但表现出非常好的选择性,将这些化合物定位为潜在的抗结核药物.化合物6D是该系列中最好的一种,对 Mtca 2 的k I值为 9.5 µm.大多数化合物对 Mtb H37Rv 菌株表现出中等至非常好的抑制作用;化合物11K的最低抑制浓度为 1 µg/ml.分子对接研究表明,化合物6D和11K显示出与锌离子的金属配位,就像经典的 Ca 抑制剂一样.
Doi:10.1002/ardp.202400064

专利信息

专利号:WO-2009054923-A2
优先权日:2007-10-24
标 题 :Synthesis and crystalline forms of cb-1 antagonist/inverse agonist

专利号:US-2010292282-A1
优先权日:2007-10-24
标题:Synthesis and crystalline forms of cb-1 antagonist/inverse agonist
发明人：CAMPOS KEVIN R; CHEN CHENG-YI; FOLEY JENNIFER R; HILLIER MICHAEL; JEN WENDY S; KASSIM AMUDE M; KLAPARS ARTIS; PERESYPKIN ANDREY V; ROSNER THORSTEN; SAVARIN CECILE G; TUDGE MATTHEW; VARIANKAVAL NARAYAN; VYDRA VICKY; ZHAO DALIAN
权利人:CAMPOS KEVIN R; CHEN CHENG-YI; FOLEY JENNIFER R; HILLIER MICHAEL; JEN WENDY S; KASSIM AMUDE M; KLAPARS ARTIS; PERESYPKIN ANDREY V; ROSNER THORSTEN; SAVARIN CECILE G; TUDGE MATTHEW; VARIANKAVAL NARAYAN; VYDRA VICKY; ZHAO DALIAN
摘要:The present invention relates to a process for producing crystalline 3-[(1S)-1-(1-{(S)-(4-chlorophenyl)[3-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl]methyl}azetidin-3-yl)-2-fluoro-2-methyl-propyl]-5-fluorobenzonitrile, and novel salts, solvates, hydrates and polymorphs thereof.

专利号:JP-2011502119-A
优先权日:2007-10-24
标题 :Synthesis and crystals of CB-1 antagonist / inverse agonist

专利号:CN-113121426-B
优先权日:2021-03-12
标题 :Synthesis method of myrtenal aldehyde group dihydrazide compounds with fungal inhibition activity

专利号:AU-2008317482-A1
优先权日:2007-10-24
标题:Synthesis and crystalline forms of CB-1 antagonist/inverse agonist

专利号:EP-2212313-A2
优先权日:2007-10-24
标题:Synthesis and crystalline forms of cb-1 antagonist/inverse agonist