CAS: 3615-44-9; Dl-Manno-[2]Heptulose

上下游产品

2-nitro-1-ethanol D-Arabinose sodium methylate D-glycero-D-galactoheptosemanno-1,3,4,5,6,7-Hexahydroxy-heptan-2-onDL-manno-1,3,4,5,6,7-Hexahydroxy-heptan-2-on volemitol perseitol 2,7-anhydro-manno-2-heptulopyranose

📜D-Glycero-D-Galactoheptose置于吡啶体系中,化学反应生成 D-甘露(型)庚酮糖
参考文献:The Synthesis Of D-Mannoheptulose,And The Preparation Of Some Of Its Derivatives
标题:The Synthesis Of D-Mannoheptulose,And The Preparation Of Some Of Its Derivatives
摘要:
DOI:10.1021/ja01876A007

专利信息

专利号:US-11845970-B2
优先权日:2016-01-15
标 题:Endo-S2 mutants as glycosynthases, method of making and use for glycoengineering of glycoproteins
发明人：WANG LAI-XI; YANG QIANG; LI TIEZHENG; TONG XIN
权利人:UNIV MARYLAND
摘要:The present invention provides for recombinant Endo-S2 mutants (named Endo-S2 glycosynthases) that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a fucosylated or nonfucosylated GlcNAc-IgG acceptor. As such, the present invention allows for the synthesis and remodeling of therapeutic antibodies thereby providing for certain biological activities, such as, prolonged half-life time in vivo, less immunogenicity, enhanced in vivo activity, increased targeting ability, and/or ability to deliver a therapeutic agent.

专利号:US-7193077-B2
优先权日:2003-08-30
标 题 :Exocyclic amine triaryl methyl protecting groups in two-step polynucleotide synthesis
发明人：DELLINGER DOUGLAS J; SIERZCHALA AGNIESZKA B; CARUTHERS MARVIN H
权利人:AGILENT TECHNOLOGIES INC
摘要:Precursors for use in the synthesis of polynucleotides and methods of using the precursors in synthesizing polynucleotides are disclosed. The precursors include a heterocyclic base having an exocyclic amine group and a substituted or unsubstituted triaryl methyl protecting group bound to the exocyclic amine group.

专利号:US-7427679-B2
优先权日:2003-08-30
标 题:Precursors for two-step polynucleotide synthesis
发明人：DELLINGER DOUGLAS J; SIERZCHALA AGNIESZKA B; CARUTHERS MARVIN H
权利人:AGILENT TECHNOLOGIES INC
摘要:Precursors for use in the synthesis of polynucleotides are disclosed. The precursors include a heterocyclic base having an exocyclic amine group and a substituted or unsubstituted triaryl methyl protecting group bound to the exocyclic amine group. In particular embodiments, the precursor has the structure: n nwherein:n O and H represent oxygen and hydrogen, respectively, R 1 is hydrido, hydroxyl, protected hydroxyl, lower alkyl, modified lower alkyl, or alkoxy, one of R 2 or R 3 is a hydroxyl protecting group; and the other of R 2 or R 3 is a reactive group capable of reacting with a reactive site hydroxyl, Base is a heterocyclic base having an exocyclic amine group, and Tram is a triaryl methyl group having the structure (V) n nwherein the broken line represents a bond to the amino nitrogen of the exocyclic amine group, and R 4 , R 5 and R 6 are independently selected from unsubstituted or substituted aryl groups, provided that at least one of R 4 , R 5 , and R 6 is an aryl group other than phenyl and other than substituted phenyl.

专利号:US-7417139-B2
优先权日:2003-08-30
标 题 :Method for polynucleotide synthesis
发明人：DELLINGER DOUGLAS J; SIERZCHALA AGNIESZKA B; CARUTHERS MARVIN H; DELLINGER GERALDINE F
权利人:AGILENT TECHNOLOGIES INC
摘要:Methods of forming an internucleotide bond are disclosed. Such methods find use in synthesis of polynucleotides. The method involves contacting a functionalized support with a precursor having an exocyclic amine triaryl methyl protecting group under conditions and for a time sufficient to result in internucleotide bond formation. The functionalized support includes a solid support, a triaryl methyl linker group, and a nucleoside moiety having a reactive site hydroxyl, the nucleoside moiety attached to the solid support via the triaryl methyl linker group. In particular embodiments, the precursor has the structure: n nwherein:n O and H represent oxygen and hydrogen, respectively R1 is hydrido, hydroxyl, protected hydroxyl, lower alkyl, modified lower alkyl, or alkoxy, one of R2 or R3 is a hydroxyl protecting group; and the other of R2 or R3 is a reactive group capable of reacting with the reactive site hydroxyl, Base is a heterocyclic base having an exocyclic amine group, and Tram is the exocyclic amine triaryl methyl protecting group.

专利号:US-6531454-B1
优先权日:1999-03-16
标 题:Glycosylated polyamines and methods of use therefor
发明人：LEARY JULIE A; GAUCHER SARA P; PEDERSEN STEVEN F
权利人:UNIV CALIFORNIA
摘要:Glycosylated polyamines comprising of mono- or oligo-saccharides that are glycosidically linked to an aliphatic polyamine, and pharmaceutically acceptable salts, prodrugs and derivatives thereof are provided. An exemplary glycosylated polyamine has the following structure: n Glycosylated polyamines, their pharmaceutically acceptable salts, prodrugs and derivatives are useful, for example, as anticancer compounds for the treatment of a variety of cancers. Methods for synthesis of glycosylated polyamines are disclosed. In addition, metal complexes of glycosylated polyamines, the preparation of such metal complexes, analytical methods using the metal complexes are provided. Methods for detecting equatorial and axial conformation of a group other than hydrogen at the C2 position of a saccharide molecule are also provided. The compounds of the invention can be used as anti-cancer agents (e.g., against breast, ovarian, colon or renal cancers). Furthermore, the compounds of the invention are ligands for the estrogen receptor and thus can be used to modulate estrogen receptor activity, for example to treat or prevent breast cancer, to treat or prevent osteoporosis or to reduce the risk of cardiovascular disease in a subject (e.g., a postmenopausal female subject).

专利号:US-11459380-B2
优先权日:2017-06-29
标 题 :Transglycosylation of endo-S and endo-S mutants for antibody glycosylation remodeling
发明人：WANG LAI-XI; TONG XIN; LI TIEZHENG
权利人:UNIV MARYLAND
摘要:The present invention provides for a one-pot enzymatic approach which does not require removal of the enzyme and purification of the intermediate after deglycosylation step, and the Endo-S treatment is able to do both deglycosylation and transglycosylation. The one-pot strategy of the present invention enables chemoenzymatic synthesis of an azido-tagged N-glycoform of monocloncal antibodies which could be further modified through orthogonal chemical ligation for various applications.