CAS: 3539-97-7; (S)-1,1,1-Trifluoropropan-2-Ol

相似化合物

17628-73-8 374-01-6 920-66-1

上下游产品

1,1,1-trifluoro-2-propanone 1,1,1-trifluoro-2,3-epoxypropane (S)-2-trifluoromethyl-oxirane methanol 5-methane-sulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid 2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid carbonic acid 4-nitro-phenyl ester (S)-2,2,2-trifluoro-1-methyl-ethyl ester (2S,4R)-4-[2-Chloro-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzenesulfonyl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl Ester 2-methyl Ester

1,1,1-三氟丙酮置于n-[(1S,2S)-1,2-Diphenyl-2-(3-Phenylpropylamino)Ethyl]-4-Methylbenzene Sulfonamide Ammonium Chloride Ruthenium,氢气体系中,用 甲醇,水 用作溶剂,50.0 °C,3.0 Mpa 条件下,反应 18.0H,以94%的收率获得
参考文献:束缚钌催化剂在酮的不对称加氢和醛的选择性加氢中的应用
标题:束缚钌催化剂在酮的不对称加氢和醛的选择性加氢中的应用
摘要:描述了一种改进的合成方法,用于合成单磺酰化二胺的束缚钌(II)配合物,以及它们在酮和醛加氢中的应用.将络合物以氯化物形式直接用于不对称酮的氢化反应,在最佳情况下,在60oc的条件下使用30 Bar氢气,可提供超过99%ee的产物,并选择性还原醛,而不是其他官能团.组.
Doi:10.1002/adsc.201200362

专利信息

专利号:US-7812161-B2
优先权日:2007-03-05
标 题 :Synthesis of GlyT-1 inhibitors
发明人：PFLEGER CHRISTOPHE; WALDMEIER PIUS; WANG SHAONING
权利人:HOFFMANN LA ROCHE
摘要:The present invention relates to a process for preparation of a compound of formula I n nwhereinn Het, R 1 , R 2 , R 3 , and n are as defined herein and pharmaceutically acceptable acid addition salts thereof, which comprises reacting a compound of formula 21 with a compound of formula 8 to obtain a compound of formula 11 and coupling the compound of formula 11 in the presence of a coupling reagent or the corresponding acid halogenide with a compound of formula 15 to obtain a compound of formula I.

专利号:WO-2008107334-A2
优先权日:2007-03-05
标题:Process for the synthesis of glyt-1 inhibitors

专利号:AU-2008223915-A1
优先权日:2007-03-05
标题:Process for the synthesis of GLYT-1 inhibitors

专利号:ES-2375585-T3
优先权日:2007-03-05
标题:PROCESS FOR THE SYNTHESIS OF GLYT-1 INHIBITORS.

专利号:US-2008221327-A1
优先权日:2007-03-05
标题:Synthesis of glyt-1 inhibitors

专利号:JP-4745446-B2
优先权日:2007-03-05
标 题:Synthesis of GLYT-1 inhibitor