芘置于aluminum Tri-Bromide,Lithium Carbonate体系中,用 四氯化碳,二氯甲烷 用作溶剂,化学反应 23.67H,反应生成1-乙酰基芘 参考文献:A Very Convenient Synthesis Of Cyclopenta[cd]Pyrene 标题:A Very Convenient Synthesis Of Cyclopenta[cd]Pyrene 摘要: Doi:10.1021/jo00289A062
专利号:EP-1501848-B1 优先权日:2002-05-08 标 题 :Synthesis of locked nucleic acid derivatives 发明人:SORENSEN MADS DETLEF; WENGEL JESPER; KOCH TROELS; CHRISTENSEN SIGNE M; ROSENBOHM CHRISTOPH; PEDERSEN DANIEL SEJER 权利人:SANTARIS PHARMA AS 摘要:The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as alpha-L-oxy-LNA, amino-LNA, alpha-L-amino-LNA, thio-LNA, alpha-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising intermediates that also can produce other LNA analogues such as oxy-LNA. Also, the compounds of the formula X are important intermediates that may be reacted with varieties of nucleophiles leading to a wide variety of LNA analogues. (Formula I)
专利号:US-6432294-B1 优先权日:2000-12-14 标题 :Electrochemical activation of organic disulfides for electrophilic substitution 发明人:GLASS RICHARD S; JOUIKOV VIATCHESLAV V; BOJKOVA NINA V 权利人:UNIV ARIZONA 摘要:Electrochemical oxidation of organic disulfides is conducted in an electrolytic solution containing an arene (e.g., anthracene, acenaphthylene, phenanthrene), and depending on the arene used and/or the product desired, an organic base (e.g., pyridine) to effect the synthesis of organothiated products in good yields.
专利号:US-6207838-B1 优先权日:1999-04-30 标 题 :Electrochemically generated organothiating reagents and their use 发明人:GLASS RICHARD S; JOUIKOV VIATCHESLAV V 权利人:UNIV ARIZONA 摘要:Electrolysis of organic disulfides in liquid sulfur dioxide is used to obtain organothiating agents, which can then be reacted with appropriate substrates to effect the synthesis of organothioaromatic compounds efficiently and in high yields. With appropriate phenolic compounds, regioselective substitution occurs in which para substitution greatly exceeds ortho substitution.
专利号:US-7569575-B2 优先权日:2002-05-08 标题 :Synthesis of locked nucleic acid derivatives
专利号:CN-106632319-A 优先权日:2016-11-17 标 题:A kind of 2-(pyrene-1-yl)-1,8-naphthyridine and its synthesis method
[参考文献]: Tsutomu Shimada, Et Al. Binding Of Diverse Environmental Chemicals With Human Cytochromes P450 2A13, 2A6, And 1B1 And Enzyme Inhibition. Chem Res Toxicol. 2013 Apr 15;26(4):517-28.