CAS: 25577-04-2; 1,6,7-Trihydroxyxanthone

主要参考文献

参考标题:Synthesis Of Xanthone Derivatives And Studies On The Inhibition Against Cancer Cells Growth And Synergistic Combinations Of Them
作者:Jie Liu,Jianrun Zhang,Huailing Wang,Zhijun Liu,Cao Zhang,Zhenlei Jiang,Heru Chen |发布日期:2017.6
摘要:34 Xanthones Were Synthesized By Microwave Assisted Technique. Their In Vitro Inhibition Activities Against Five Cell Lines Growth Were Evaluated. The Sar Has Been Thoroughly Discussed. 7-Bromo-1,3-Dihydroxy-9H-Xanthen-9-One (3-1) Was Confirmed As The Most Active Agent Against Mda-Mb-231 Cell Line Growth With An Ic50 Of 0.46 +/- 0.03 Mu M. Combination Of 3-1 And 5,6-Dimethylxanthone-4-Acetic Acid (Dmxaa) Showed The Best Synergistic Effect. Apoptosis Analysis Indicated Different Contributions Of Early/late Apoptosis And Necrosis To Cell Death For Both Monomers And The Combination. Western Blot Implied That The Combination Regulated P53/mdm2 To A Better Healthy State. Furthermore, 3-1 And Dmxaa Arrested More Cells On G2/m Phase; While The Combination Arrested More Cells On S Phase. All The Evidences Support That The 3-1/dmxaa Combination Is A Better Anti-Cancer Therapy. (C) 2017 Elsevier Masson Sas. All Rights Reserved.

合成参考文献

参考文献:10.1038/srep13570
摘要:Yokoyama T, Ueda M, Ando Y, Mizuguchi M. Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor. Scientific Reports. 2015 Aug 27;5(1):13570. doi: 10.1038/srep13570.