CAS: 2512-24-5; N-Tert-Butylbenzenesulfonamide
该化合物是一种有机化合物,其特征是附在苯环上的磺酰胺功能组,其替代成分为三丁基乙基(1,1-二甲基乙基),该化合物在室内温度上一般是固体,在有机溶剂中可以溶解,但由于乙型丁基苯丙胺组的疏水性质,其溶解性有限.
- 英文名称N-Tert-Butylbenzenesulfonamide
- 中文名称N-(叔丁基)苯磺酰胺
- IUPAC名称N-(tert-butyl)benzenesulfonamide
- 其它别名N-(Tert-Butyl)Benzenesulphonamide; Benzenesulfonamide,N-(1,1-Dimethylethyl)-; N-Tert-Butylbenzenesulfonamide Usp/ep/bp
- CAS编号2512-24-5
- MFCD编号:MFCD00462465
- 分子式:C10H15NO2S分子量:213.3
- 产品CID: 1207728
- 产品分类原料药 → 人工合成抗感染类药 → 磺胺类药及增效剂
物理性质
上下游产品
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📜叔丁胺,苯磺酰氯 以 二氯甲烷 用作溶剂,化学反应 12.0H,反应生成N-叔丁基苯磺酰胺
参考文献:对人at1和at2亚型具有同等亲和力的强效和口服活性血管紧张素ii受体拮抗剂.
标题:对人at1和at2亚型具有同等亲和力的强效和口服活性血管紧张素ii受体拮抗剂.
摘要:为了阻止由血管紧张素ii(aii)与at1和at2受体之间的相互作用引起的影响,我们一直致力于发现对人at1和at2受体亚型表现出同等效力的口服活性非肽aii拮抗剂.一系列先前制备的纳摩尔(ic50)三取代的1,2,4-三唑啉酮联苯磺酰胺双作用aii拮抗剂已在五个不同位置进行了修饰,以增加at2结合亲和力,维持at1活性并降低人肾上腺at2 / At1效能比(ic50比率)>=10.使用多种在三唑啉酮的c5处具有乙基且在n4处具有3-氟取代基的化合物,可以达到目标的人肾上腺效能比<或= 1.-联芳基甲基部分.这些化合物中最受青睐的化合物44在at1(兔主动脉)和at2(大鼠中脑)受体上均表现出亚纳摩尔效价,对后者稍有偏爱,人肾上腺at2 / At1 Ic50比率为1.具有n2-[2-溴-5-(戊酰氨基)苯基]取代基的叔丁基磺酰基氨基甲酸酯在1 Mg / Kg时具有出色的iv活性(100%峰抑制,作用时间>=4
Doi:10.1021/jm00019A004
海关参考信息
- 2902200000-苯
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专利信息
专利号:US-2004028702-A1
优先权日:2002-07-26
标 题:Muramic acid derivative compounds
发明人：MALETIC MILANA M; LEEMAN AARON H; SANTORELLI GINA M; WADDELL SHERMAN T
摘要:The present invention pertains to the combinatorial synthesis of antibacterial agents that inhibit the Mur-pathway enzymes involved in bacterial cell wall assembly. The method uses p-alkoxybenzylidene as the linker for the attachment of a derivatized muramic acid to the polymeric resin support. This intermediate becomes the starting point for the combinatorial synthesis, which in conjunction with split-pooling techniques allows rapid synthesis of diverse analogues for high-throughput screening (HTS). The invention is further directed to the libraries of these finished compounds that vary at the peptide, N-acyl and anomeric UDP positions.
专利号:CN-106588811-A
优先权日:2016-12-07
标题 :A kind of method for the asymmetric synthesis of the benzoendosulphonamide compound containing chiral quaternary carbon center
专利号:CN-106588811-B
优先权日:2016-12-07
标题 :A kind of method for asymmetric synthesis of chiral quaternary carbon center-containing benzolactone compounds
专利号:CN-107459471-B
优先权日:2017-09-04
标 题:Synthesis method of N-tert-butyl benzene sulfonamide
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:A General Iodine-Mediated Synthesis Of Primary Sulfonamides From Thiols And Aqueous Ammonia作者:Jian-Bo Feng,Xiao-Feng Wu
摘要:A General And Efficient Methodology For Preparing Primary Sulfonamides Has Been Developed. In The Presence Of Iodine As The Catalyst And Tbhp (70% In Water) As The Oxidant, A Wide Range Of Primary Sulfonamides Were Prepared From The Corresponding Thiols And Aqueous Ammonia In Moderate To Good Yields.
合成参考文献
摘要:Sainsbury, M., Science of Synthesis Knowledge Updates, (2010) 1, 255.
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