专利号:US-4900814-A 优先权日:1985-12-16 标题:Synthesis of podophyllotoxin derivatives 发明人:STERLING JEFFREY; NUDELMAN ABRAHAM; HERZIG JAACOV; KEINAN EHUD; WEINER BEN Z 权利人:STERLING JEFFREY; NUDELMAN ABRAHAM; HERZIG JAACOV; KEINAN EHUD; WEINER BEN Z 摘要:There is provided a novel process for the production of the epipodophyllotoxin glycosides, Etoposide and Teniposide. There are further provided certain novel 4'-demethylepipodophyllotoxin derivatives of the following formula ##STR1## where W is hydrogen or 2,3-di-O-acetyl-4,6,O-ethylidene-D-glucopyran-1-yl. These intermediates are easily transformed into Etoposide and Teniposide and into further derivatives of this series.
专利号:WO-9742194-A1 优先权日:1996-05-08 标 题:Process for the preparation of an indacene compound 发明人:CALDERON JOSE MARIA BUENO; CHICHARRO GONZALO JESUS; FIANDOR ROMAN JOSE; HUSS SOPHIE; WARD RICHARD ANTHONY 权利人:GLAXO WELLCOME SA; CALDERON JOSE MARIA BUENO; CHICHARRO GONZALO JESUS; FIANDOR ROMAN JOSE; HUSS SOPHIE; WARD RICHARD ANTHONY 摘要:A process for the preparation of a compound of formula (I); and novel intermediates for use in the synthesis.
专利号:US-8329923-B2 优先权日:2010-06-17 标 题:4, 4′ disubstituted 4H-cyclopentadithiophene and new methods for synthesizing the same 发明人:VANDERZANDE DIRK; LUTSEN LAURENCE; VAN MIERLOO SARAH 权利人:VANDERZANDE DIRK; LUTSEN LAURENCE; VAN MIERLOO SARAH; IMEC; UNIV HASSELT 摘要:The present preferred embodiments relate to a method for the synthesis of a compound having the following general formula: n nthe method comprising the step of reacting, in presence of a diprotic acid having a negative pKa, a compound having the general formula:n n nwherein R 1 and R 2 are organic groups and wherein X and Y are independently selected from the group consisting of hydrogen, chloro, bromo, iodo, boronic acid, boronate esters, borane, pseudohalogen and organotin. It further relates to compounds so obtained and to compounds resulting from the ring closure of compound (II).
专利号:EP-0226202-B1 优先权日:1985-12-16 标题 :Synthesis of podophylotoxin type compounds
专利号:EP-0226202-A2 优先权日:1985-12-16 标 题:Synthesis of podophylotoxin type compounds
专利号:CN-114408943-B 优先权日:2021-11-26 标题 :A kind of solid-phase synthesis prepares the method for cuprous thiocyanate nanoparticle
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 211. 摘要:Collings, J. C., Science of Synthesis Knowledge Updates, (2013) 4, 345. 摘要:Archives of Environmental Contamination and Toxicology., 14(111), 1985 [] 摘要:Sangyo Igaku. Japanese Journal of Industrial Health., 15(3), 1973 摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/S_schafer851.pdf