CAS: 19396-06-6; (S)-2-((2S,3S,4S)-2-Amino-5-(Carbamoyloxy)-3,4-Dihydroxypentanamido)-2-((2R,3S,4R,5R)-3,4-Dihydroxy-5-(5-(Hydroxymethyl)-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-yl)Tetrahydrofuran-2-yl)Acetic Acid

该化合物是一种核分子的抗生素,来源于主要因其抗硫素特性而得到承认的Cacooi,它抑制了Chitin 合成酶,干扰了真菌的细胞壁合成,使其对广泛的植物病原体,特别是影响作物的植物病原体有效,它的行动方式尽量减少了与其他杀真菌剂的交叉抗药性,提高了其在综合虫害管理中的效用. Polyoxin B 具有生物降解性,对非目标生物体的毒性较低,符合可持续农业做法.它对于稻草树脂和苹果罐等疾病的防治效果,加上其环境兼容性,将它定位为植物疾病控制的宝贵工具.

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上下游产品

CAS号4433-40-3 5-羟甲基脲嘧啶 | CAS号155154-68-0 methyl (5-azido... | CAS号31517-04-1 Pyrimidine, 2,4...

合成工艺路线路线简述

    📜5-羟甲基脲嘧啶置于palladium On Activated Charcoal Lithium Hydroxide,三甲基氯硅烷,三氟甲磺酸三甲基硅酯,氢气,碳酸氢钠,N,N-二异丙基乙胺,三氟乙酸体系中,用 四氢呋喃,1,4-二氧六环,甲醇,水,二甲基亚砜,甲苯,乙腈 用作溶剂,化学反应 47.5H,反应生成多抗霉素
    参考文献:Uchida,Kimio; Kato,Keisuke; Yamaguchi,Kentaro,Heterocycles,2000,Vol. 53,# 10,P. 2253-2259
    标题:Uchida,Kimio; Kato,Keisuke; Yamaguchi,Kentaro,Heterocycles,2000,Vol. 53,# 10,P. 2253-2259

    海关参考信息

    专利信息


    专利号:WO-2025056767-A1
    优先权日:2023-09-15
    标题 :Process for the preparation of enantiomerically enriched aliphatic amines
    发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

    专利号:US-12241103-B2
    优先权日:2015-02-17
    标 题:Production system and method of production for organic compound or microorganism
    发明人:KISHINO MITSUHIRO; KOJIMA HIROYUKI; HOSONO HIDEO; HARA MICHIKAZU; KITANO MASAAKI; YOKOYAMA TOSHIHARU; NUMAGUCHI TORU; ITO MUNENOBU; YAMADA KAZUTERU; NOGUCHI HIROMI
    权利人:AJINOMOTO KK; TOKYO INST TECH
    摘要:Provided is a novel production system that does not involve, or can minimize, the transport of liquid ammonia in the production of an organic compound or the production of a microorganism by microbial fermentation. A production system for an organic compound or a microorganism includes: an ammonia synthesis apparatus in which an ammonia-containing gas is synthesized by reaction of a source gas containing hydrogen and nitrogen in the presence of a supported ruthenium catalyst; and a culture apparatus that cultures a microorganism having organic compound productivity using ammonia originating from the ammonia-containing gas obtained by using the ammonia synthesis apparatus.

    专利号:US-10941427-B2
    优先权日:2015-02-17
    标题:Production system and method of production for product selected from nitrogen-containing product and fermented and cultured product
    发明人:KISHINO MITSUHIRO; KOJIMA HIROYUKI; HOSONO HIDEO; HARA MICHIKAZU; KITANO MASAAKI; YOKOYAMA TOSHIHARU; NUMAGUCHI TORU; ITO MUNENOBU; YAMADA KAZUTERU; NOGUCHI HIROMI
    权利人:AJINOMOTO KK; TOKYO INST TECH
    摘要:A production system for a product selected from a nitrogen-containing product and a fermented and cultured product that does not involve (or can minimize) the transport of liquid ammonia can include: an ammonia synthesis apparatus in which an ammonia-containing gas is synthesized by reaction of a source gas containing hydrogen and nitrogen in the presence of a supported metal catalyst containing as a support one or more selected from the group consisting of: i) a conductive mayenite compound; ii) a two-dimensional electride compound or a precursor thereof; and iii) a complex formed of a support base containing at least one metal oxide selected from ZrO2, TiO2, CeO2, and MgO and a metal amide represented by a formula M(NH2)x (where M represents one or more selected from Li, Na, K, Be, Mg, Ca, Sr, Ba, and Eu; and x represents a valence number of M) supported by the support base.

    专利号:WO-2020226482-A1
    优先权日:2019-05-09
    标题:Synergistic compositions for controlling plant pathogens with chitinolytic microorganisms / organic acid combinations and method of use thereof
    发明人:LAI HONG HENG
    权利人:LAI HONG HENG
    摘要:The present invention relates to pesticidal compositions and methods for controlling plant pathogens, particularly basal stem rot in the oil palm primarily caused by Ganoderma species. The pesticidal compositions comprising, as active components: (A) Bioactive compound derived from a whole broth culture of an chitinolyic microorganisms, wherein the bioactive compound comprises any or any combination of: chitinolyic microorganism, whole cell broths, liquid cultures, spores, pure cultures, cell fraction, substances, suspensions, supernatants, filtrates, extract or a cell-free extract thereof or metabolite thereof or isolated compounds, wherein the bioactive compound is derived from at least one chitinolyic microorganisms that degrade chitinous substrates. The said chitinolytic microorganism is bacteria belonging to genus Bacillus, Streptomyces and/or fungal genus Trichoderma; (B) at least one organic acid; and (C) at least one pesticide selected from chemical pesticides, microbial pesticides, plant defense activators, cuticle degrading enzymes, cell wall synthesis inhibitors, bacteriocins, antifungal peptides, antimicrobial preservatives, plant oil or plant extract. More specifically, this invention envisions the use of bioactive compounds and/or metabolites from chitinolyic microorganisms in combination essentially of organic acid and the compositions comprising them, in the use form as fungicides and/or insecticides, also be present as 'booster' to other pesticides results in many cases in an expension of pesticidal spectrum of activity or in a prevention of pesticide resistance development. Furthermore, in many cases, synergistic effects are obtained. In various embodiments, the organic acid consists essentially of acetic acid, preferably acetic acid from a fermentation. The formulation is typically applied to agricultural soil or plant material. In a particular, the present invention can be used in combination with a carrier selected from the plant growth nutrient, organic fertilizer or inorganic/organic mixture fertilizer. Although the following description relates almost exclusively to managing basal stem rot (BSR) disease in oil palm primarily caused by Gonoderma species. It will be appreciated by those skill in the art that the invention could be used to treat other diseases and pests of other plants, includes but is not limited to a fungus, bacteria, actinomycete, virus, insects, Acari and/or nematodes.

    专利号:US-5433947-A
    优先权日:1992-12-15
    标 题 :Antifungal synergistic combination of enzyme fungicide and non-enzymatic fungicide and use thereof
    发明人:HARMAN GARY E; LORITO MATTEO; PIETRO ANTONIO D; HAYES CHRISTOPHER K
    权利人:CORNELL RES FOUNDATION INC
    摘要:Antifungal composition comprising synergistic combination of fungal cell wall degrading enzyme selected from the , group consisting of chitinolytic enzymes, glucanolytic enzymes and cellulases and non-enzymatic fungicides selected from the group consisting of sterol synthesis inhibiting fungicides (e.g., flusilazole and miconazole) and thiol group inactivating fungicides which are not specific to fungal cell membranes (e.g., captan) are applied in an antifungal effective amount to fungus to be inhibited or to a locus to be protected from said fungus.

    专利号:US-12102085-B2
    优先权日:2013-10-18
    标题 :Insecticidal active mixtures comprising carboxamide compound
    发明人:SIKULJAK TATJANA; GEWEHR MARKUS
    权利人:BASF AGROCHEMICAL PRODUCTS BV
    摘要:The present invention relates to pesticidal mixtures comprising as active compound I an insecticidal active carboxamide derivative and at least one active compound II selected from a group M comprising acteylcholine esterase inhibitors, GABA-gated chloride channel antagonists, sodium channel modulators, nicotinic acteylcholine receptor agonists/antagonists, allosteric nicotinic acetylcholine receptor activators, chloride channel activators, juvenile hormone mimics, homopteran feeding blockers, mit grow inhibitors, inhibitors of mitochondrial ATP synthase, uncouplers of the oxidative phosphorylation, inhibitors of the chitin biosynthesis, moulting disruptors, ecdyson receptor agonists, octamin receptor agonists, inhibitors of the MET, voltage-dependent sodium channel blockers, inhibitors of the lipid synthesis, ryanodine receptor modulators and other compounds as defined in the description, in synergistically effective amounts.The invention relates further to methods and use of these mixtures for combating and controlling insects, arachnids or nematodes in and on plants, and for protecting such plants being infested with pests, especially also for protecting plant proparagation material, such as seeds.

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    主要参考文献


    1: Liu L, Wu H, Long Y, Yang X, Du C, Xu Y, Ji Q. Novel spiro[pyrrolidine-2,3'-quinoline]-2'-one derivatives containing piperazine fragment as potential chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2023 Nov 15;260:115777. doi: 10.1016/j.ejmech.2023.115777. Epub 2023 Aug 30.
    255:115388. doi: 10.1016/j.ejmech.2023.115388. Epub 2023 Apr 26.
    243:114723. doi: 10.1016/j.ejmech.2022.114723. Epub 2022 Aug 31. 369(1):fnac048. doi: 10.1093/femsle/fnac048.

    合成参考文献


    摘要:Farm Chemicals Handbook., -(C244), 1991
    摘要:Japan Pesticide Information., (40)(32), 1982
    参考文献:10.1016/j.bmc.2014.04.042
    摘要:Ji Q, Yang D, Wang X, Chen C, Deng Q, Ge Z, Yuan L, Yang X, Liao F. Design, synthesis and evaluation of novel quinazoline-2,4-dione derivatives as chitin synthase inhibitors and antifungal agents. Bioorg Med Chem. 2014 Jul 01;22(13):3405–13. doi: 10.1016/j.bmc.2014.04.042.
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