CAS: 152460-08-7; 1-(2-Methyl-5-Nitrophenyl)Guanidine Nitrate

相似化合物

77252-56-3 152460-07-6 581076-64-4

上下游产品

CYANAMID 2-methyl-5-nitroaniline nitric acid o-toluidineo-toluidine 3STLL3 imatinib mesylate 696SKI696 STI-OH

📜2-氨基-4-硝基甲苯 反应生成(2-甲基-5-硝基苯基)胍硝酸盐
参考文献:Pyrimidine Derivatives And Processes For The Preparation Thereof
标题:Pyrimidine Derivatives And Processes For The Preparation Thereof
摘要:描述了公式i的n-苯基-2-嘧啶胺衍生物,其中r.Sub.1是4-吡啶基,1-甲基-1H-吡咯基,氨基或氨基-低碳基取代的苯基,其中每种情况下的氨基基团是自由的,烷基化或酰基化的,1H-吲哚基或1H-咪唑基与五元环碳原子键合,或未取代或取代的环碳原子上键合未取代或取代的吡啶基,并在氮原子上未取代或取代为氧原子的情况下.R.Sup.2,R.Sup.3,R.Sup.9,X,Y,N和r.Sup.10在权利要求1中定义.这些化合物可以用于肿瘤疾病的治疗等方面.

专利信息

专利号:US-2011097268-A1
优先权日:2006-08-23
标 题 :Radiohaloimatinibs and methods of their synthesis and use in pet imaging of cancers
发明人：BORNMANN WILLIAM; ALAUDDIN MIAN; GELOVANI JURI; GHOSH PRADIP; GUO LIWEI; HAN DONGMEI; MAXWELL DAVID; MUKHOPADHYAY UDAY; PENG ZHENGHONG; SHAVRIN ALEKSANDR; YING YUNMING
权利人:UNIV TEXAS
摘要:We disclose methods of synthesizing radiohalidated organic compounds and their use in positron emission tomography (PET) imaging of cancer cells.

专利号:EP-3333162-A1
优先权日:2016-12-12
标题 :Metod for preparing n-(2-methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine
发明人：NIKLEWICZ PAWEL GRZEGORZ; LAPCZYNSKI RADOSLAW MIECZYSLAW; PLUTA JANUSZ; OWCZAREK ARTUR; KAROLEWICZ BOZENA
权利人:SILESIAN CATALYSTS SP Z O O
摘要:The invention relates to a method for preparing N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine, a compound from the group of 2-aminopyrimidine derivatives, which is the precursor of active pharmaceutical ingredients, in particular imatinib. n The method of production of N-(2-methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine or other 2-pyrimidineamine lies in that 3-(dimethylamino)-1-(3-pyridyl)prop-2-en-1-one, after being mixed with 1-(2-methyl-5-nitrophenyl)-guanidine nitrate and an alkali hydroxide, preferably sodium hydroxide dissolved in a solvent in the form of dimethyl sulfoxide (DMSO), is subjected to coupling reaction under a pressure from 1 to 50 MPa in a rotating microwave field, with an absorbed microwave power volumetric density contained in the range from 1 W/cm 3 to 1 MW/cm 3 . The coupling process is preferably conducted at a temperature from 300 to 773K, wherein the volumetric density of microwave power absorbed by the reaction system under isothermal process conditions is controlled during the synthesis process. n In a variant of the method, the reagents are subjected to coupling reaction in a microwave reactor, in which the reaction vessel is placed in a container equipped with at least two microwave ports supplying microwave energy to the reagents positioned in the reaction vessel by means of electrodes that are isolated from the reagents by a dielectric layer and play the role of coupling elements.

专利号:WO-2008024829-A2
优先权日:2006-08-23
标 题:Radiohaloimatinibs and methods of their synthesis and use in pet imaging of cancers