CAS: 14246-53-8; 2-Octanamidoacetic Acid

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2441-41-0 14305-32-9 7596-88-5

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CAS号56-40-6 甘氨酸 | CAS号111-64-8 辛酰氯 | CAS号544-31-0 十六酰胺乙醇 | CAS号111-57-9 硬脂酰胺MEA | CAS号142-78-9 N-(2-羟乙基)十二烷基酰胺 | CAS号142-58-5 肉豆蔻酰胺MEA | CAS号7112-02-9 N-(2-hydroxyeth... | CAS号7726-08-1 N-Caprinoyletha... | CAS号124-07-2 辛酸 | CAS号623-66-5 辛酸酐 | CAS号1100753-83-0 N-(((S)-4-pheny... | CAS号937-52-0 (R)-α-甲基苯丙胺

辛酰氯置于4-二甲氨基吡啶,水,三乙胺,Lithium Hydroxide体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 12.0H,反应生成辛酰甘氨酸
参考文献:使用基于氧杂降冰片烷的非离子两亲物的药物递送载体的模块化方法.
标题:使用基于氧杂降冰片烷的非离子两亲物的药物递送载体的模块化方法.
摘要:使用氨基酸单元作为亲水性和亲脂性结构域之间的间隔基来控制具有羟基化氧杂硼硼烷头部的非离子两亲物的自组装,以获得球形的超分子聚集体.评估了这些系统包含布洛芬等治疗剂的能力及其药物释放曲线.除了指导组装外,还发现中间的氨基酸单元也有助于药物的包封.胆固醇的存在改善了它们的载药能力,并且通过含有苯丙氨酸残基作为间隔物(nc1C)的制剂显示出高达66%的包封效率.在这种情况下,没有爆发释放,并且在24小时结束时观测到45%的药物释放(参见基于大豆磷脂酰胆碱的制剂= 49%).Sem,Cryo-Tem,
Doi:10.1039/c6Tb02192A

专利信息

专利号:WO-2024058717-A1
优先权日:2022-09-14
标题:Engineering of rhizomucor miehei lipase towards amide bond formation for the synthesis of medium to long chain n-acyl glycines in aqueous media
发明人：LI ZHI; KUA KAI BIN; NGUYEN KIEN TRUC GIANG
权利人:WILMAR INTERNATIONAL LTD; NAT UNIV SINGAPORE
摘要:Described herein are lipase variants of a Rhizomucor Miehei Lipase. The lipase variants may be used to prepare medium to long chain N-acyl glcyines. The variants may have a parent sequence of SEQ ID NO: 3; and a D156 substitution and/or a L258 substitution, wherein the D156 substitution is selected from the group consisting of serine (S), glycine (G), glutamic acid (E), and threonine (T), wherein if the D156 substitution is glycine, the lipase variant comprises at least one other substitution, and the L258 substitution is selected from the group consisting of lysine (K), arginine (R), glutamine (Q), asparagine (N), histidine (H), and serine (S). The variants may have a parent sequence of SEQ ID NO: 3; and at least one substitution of the following amino acids: D156, L258. L267, V254, L255, N264, T265, S83, S84, W88, R30, R86, S56, L58, and 1I59.

专利号:US-11332564-B2
优先权日:2020-03-19
标 题:Method to produce stimuli sensitive UV absorbing polymers
发明人：KOSHTI NIRMAL; KURAKULA THULASIRAMREDDY PRABHU CHARAN
权利人:GALAXY SURFACTANTS LTD
摘要:Eco-friendly aqueous synthesis of substantive, UV-absorbing, cationic polymers with ‘inverse temperature dependent solubility’ are described in the present invention. These polymers are water-soluble at ambient temperature and water-resistant at temperature of human body as well as in the presence of electrolytes. This property makes these polymers useful for personal care products that are designed for protecting skin and hair from damages of UV radiation. n The invention relates to aqueous synthesis of polymers of Formula I wherein, ArCO is an UV absorbing moiety selected from 2-cyano-3,3-diphenyl acryloyl, and p-methoxy cinnamoyl, R 1 is selected from H and C 1 -C 3 alkyl group, and R 2 is selected from C 1 -C 3 alkyl group, m and n are integers and a ratio of m to n is 40:5 to 40:1.

专利号:WO-2006097348-A1
优先权日:2005-03-15
标 题:Use of agents such as nonpolymeric nitric oxide donors for making the lips full again and/or colouring the lips
发明人：CALS-GRIERSON MARIE-MADELEINE
权利人:OREAL; CALS-GRIERSON MARIE-MADELEINE
摘要:The invention relates in particular to the cosmetic use (i) of at least one agent for promoting the production of NO in and/or on the lips, chosen from nitric oxide NO donors or precursors; nonpolymeric NO releasers; and NO synthase synthesis and/or activity stimulators; or (ii) of other agents for promoting microcirculation in the skin, chosen from potassium channel openers; calcium channel blockers; phosphodiesterase inhibitors; flavonoids; vasodilator peptides that are not NO donors; temperature modulators; agents for promoting the stimulation and/or maintenance of angiogenesis; agents for promoting the stimulation of endothelial cell proliferation; agents for promoting endothelial cell migration; and mixtures thereof, in a makeup and/or care composition for the lips, as an agent for naturally making the lips full again and/or naturally coloring the lips. It also relates to specific care and/or makeup compositions for the lips containing said agent, and also to a cosmetic process aimed at making the lips naturally full and/or colored, using said compositions .

专利号:US-7875707-B2
优先权日:2002-05-03
标 题:Disaccharides for drug discovery
发明人：MEUTERMANS WIM; WEST MICHAEL; ADAMSON GEORGE; THANH LE GIANG; DRINNAN NICHOLAS B; ABBENANTE GIOVANNI; BECKER BERND; GRATHWOHL MATTHIAS; RAJARATNAM PREMRAJ; TOMETZKI GERALD
权利人:ALCHEMIA LTD
摘要:Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.

专利号:CN-120290533-A
优先权日:2025-04-22
标 题 :Acylase mutant and application thereof in synthesis of octanoylglycine

专利号:US-8933207-B2
优先权日:2010-07-28
标 题 :Drug-ligand conjugates, synthesis thereof, and intermediates thereto
发明人：CHEN ZHIYU; LANCASTER THOMAS M; ZION TODD C
权利人:CHEN ZHIYU; LANCASTER THOMAS M; ZION TODD C; SMARTCELLS INC
摘要:The present invention relates to methods for synthesizing compounds of formula I or pharmaceutically acceptable salts thereof: I wherein each of X, Alk 1 , Alk 2 , and W are as defined and described herein.