CAS: 112809-52-6; 4,4'-((4H-1,2,4-Triazol-4-yl)Methylene)Dibenzonitrile

上下游产品

CAS号288-88-0 1,2,4-三氮唑 | CAS号69545-39-7 4,4’-二氰基二苯溴甲烷 | CAS号112809-27-5 4-(4-氰基苄基)-1,2,4-三唑 | CAS号1194-02-1 对氟苯腈 | CAS号112809-25-3 4-(1H-1,2,4-三唑-...

4-(4-氰基苄基)-1,2,4-噻唑,对氟苯腈置于potassium Tert-Butylate体系中,用 N,N-二甲基乙酰胺 用作溶剂,化学反应生成4,4'-(4H-1,2,4-三唑-4-基亚甲基)双苯腈
参考文献:Cn116375657
标题:Cn116375657

专利信息

专利号:WO-2010146391-A1
优先权日:2009-06-15
标题:Regioselective synthesis of letrozole
发明人：GORE VINAYAK GOVIND; SHUKLA VINAY KUMAR; BHANDARI SHERYAS; HASBE SURESH; MEKDE SANDEEP
权利人:GENERICS UK LTD; MYLAN INDIA PRIVATE LTD; GORE VINAYAK GOVIND; SHUKLA VINAY KUMAR; BHANDARI SHERYAS; HASBE SURESH; MEKDE SANDEEP
摘要:The present invention relates to an improved process for the preparation of letrozole (I) and its pharmaceutically acceptable salts, to compositions comprising letrozole or a pharmaceutically acceptable salt thereof, and to uses of such compositions. In particular it relates to a process and to novel intermediates for preparing letrozole and its salts substantially free from regioisomeric impurities.

专利号:US-7705159-B2
优先权日:2005-07-06
标题:Process for the preparation of letrozole
发明人：MACDONALD PETER LINDSAY; BIGATTI ETTORE; ROSSETTO PIERLUIGI; HAREL ZVI
权利人:SICOR INC
摘要:The invention provides a high-yield process for the preparation of letrozole having a high purity, without the need for removal of the 4-[1-(1,3,4-triazolyl)methyl]benzonitrile impurity at the intermediate stage. The invention also provides a process for the synthesis of letrozole in which formation of the impurity 4-[1-(1,3,4-triazolyl)methyl]benzonitrile during the first stage is minimized. In the process, a 4-(halomethyl)benzonitrile is reacted with a salt of 1H-1,2,4-triazole, reducing the formation of the impurity. Preferably, the preparation is conducted as a one-pot process.

专利号:US-8003804-B2
优先权日:2006-03-17
标题:Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-triazol-1-yl)methyl] benzonitrile and 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile intermediate
发明人：PATHI SRINIVAS LAXMINARAYAN; KANKAN RAJENDRA NARAYANRAO; RAO DHARMARAJ RAMACHANDRA; VASANT CHIKHALIKAR SANDIP
权利人:CIPLA LTD
摘要:The present invention relates to a process for the preparation of 4-[1-(4-cyano phenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile (letrozole), substantially free from its isomeric impurity. The preparation involves reaction of 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile with 4-fluorobenzonitrile in the presence of an organic solvent and a silicon amine. The present invention also relates to a process for the preparation of 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile which involves: (a) the reaction of a 4-halomethyl benzonitrile with 1,2,4-triazole in the presence of cesium carbonate and an organic solvent to obtain a reaction mass comprising 4-[1-(1,2,4-triazole-1-yl)methyl]benzonitrile of formula II; and (b) precipitation of 4-[1-(1,2,4-triazole-1-yl)methyl]benzonitrile (II) from the reaction mass using a suitable organic solvent.

专利号:WO-2007107733-A1
优先权日:2006-03-17
标 题 :Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-tr1azol-1-yl)methyl] benzonitrile and 4-[1-(1h-1,2,4-triazol-1-yl)methylene benzonitrile intermediate

专利号:US-2009270633-A1
优先权日:2006-03-17
标题 :Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-triazol-1-yl)methyl] benzonitrile and 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile intermediate