CAS: 10297-06-0; 6-Chlorohex-1-Yne

该化合物是一种具有分子式 C6H9Cl 的卤化烷.该化合物是有机合成的多用途中间体,特别是在交叉反应和功能化白蚁的准备方面.其终端烷基子组能够有效地参与点击化学,如铜催化亚化二烷-烷循环(CuAAC),而氯替代体则提供一个反应场,供进一步衍生.该化合物的稳定性和定义明确的再活动使其适合于在制药,农用化学和材料科学方面的应用.通常在不热条件下处理,以保持其完整性.高纯度中可用,6-Chrloro-1-hexyne是先进的合成工作流程的一个有价值的建筑块.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号928-90-5 5-己炔-1-醇 | CAS号6940-78-9 1-溴-4-氯丁烷 | CAS号1066-26-8 乙炔化钠,二甲苯溶液 | CAS号10297-05-9 1-氯-4-碘丁烷 | CAS号14267-92-6 5-氯-1-戊炔 | CAS号74-86-2 乙炔 | CAS号3741-00-2 戊基环戊烷 | CAS号928-89-2 6-氯-1-己烯 | CAS号486-70-4 ((1R,9aR)-八氢-1H... | CAS号18804-33-6 6-chlorohexan-2-ol | CAS号2468-56-6 6-碘-1-己炔 | CAS号29333-99-1 N,N,N',N'-tetra... | CAS号1528-30-9 亚甲基环戊烷 | CAS号287-92-3 环戊烷 | CAS号930-26-7 3-methylidenecy... | CAS号110-83-8 环己烯

合成工艺路线路线简述

    📜5-己炔-1-醇置于吡啶,氯化亚砜体系中,用80%的收率获得6-氯己炔
    参考文献:10.1080/10587250290088438
    标题:10.1080/10587250290088438
    摘要:
    Doi:10.1080/10587250290088438

    专利信息


    专利号:US-2008086013-A1
    优先权日:2006-06-15
    标 题:Carbometallation of alkynes and improved synthesis of uniquinones
    发明人:LIPSHUTZ BRUCE H
    权利人:UNIV CALIFORNIA
    摘要:Methods for the carbometallation of alkynes are presented. Those are useful for the synthesis of CoQ 10 and other ubiquinones as well as for the synthesis of ubiquinol analogs.

    专利号:US-2025179012-A1
    优先权日:2022-03-04
    标 题:Synthesis of sulfur(vi) compounds and reagents for same
    发明人:LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
    权利人:H LEE MOFFITT CANCER CT & RES
    摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

    专利号:WO-2025101716-A1
    优先权日:2023-11-07
    标题:Processes for synthesis of trifunctionalized sulfur(vi) compounds
    发明人:LOPCHUK JUSTIN; SHULTZ ZACHARY; ATHAWALE PARESH
    权利人:H LEE MOFFITT CANCER CT & RES
    摘要:This disclosure describes processes for the asymmetric synthesis of trifunctionalized sulfur(VI) containing organic compounds of Formula I and Formula VI, as well as compounds of Formula I and Formula VI prepared by the processes described.

    专利号:US-10829792-B2
    优先权日:2017-03-21
    标 题 :Biocatalytic synthesis of strained carbocycles
    发明人:CHEN KAI; HUANG XIONGYI; KAN S B JENNIFER
    权利人:CALIFORNIA INST OF TECHN
    摘要:Provided herein are methods for producing products containing strained carbocycles, such as cyclopropene moieties and/or bicyclobutane moieties. The methods include combining an alkyne and a carbene precursor in the presence of a heme protein, e.g., a cytochrome P450, under conditions sufficient to form the strained carbocycle. Reaction mixtures for producing strained carbocycles are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming cyclopropenes, bicyclobutanes, and related products.

    专利号:WO-2024186075-A1
    优先权日:2023-03-03
    标题 :Synthesis method of antibody-drug conjugates using proximity effect-based site-selective antibody labeling
    发明人:LEE HYUN SOO; KIM SOOIN; KWEON YONGSEOK
    权利人:UNIV SOGANG RES & BUSINESS DEVELOPMENT FOUND; RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIV
    摘要:The present invention relates to a method for the synthesis of an antibody-drug conjugate using proximity effect-based site-selective antibody labeling. Provided according to the present invention may be a method for the synthesis of an antibody-drug conjugate by site-selectively introducing a drug into an antibody using a pyridinium oxime derivative (labeling mediator protein) introduced into a binding protein containing a non-standard amino acid.

    专利号:US-8236976-B2
    优先权日:2004-03-09
    标 题 :Processes for highly enantio- and diastereoselective synthesis of acyclic epoxy alcohols and allylic epoxy alcohols
    发明人:WALSH PATRICK; LURAIN ALICE E; KELLY ANN R; MAESTRI AARON G
    权利人:WALSH PATRICK; LURAIN ALICE E; KELLY ANN R; MAESTRI AARON G; UNIV PENNSYLVANIA
    摘要:The inventive subject matter relates to novel processes for making an epoxy alcohol from an aldehyde, comprising the steps of: (a) adding (i) an organozinc compound or (ii) divinylzinc compound and an diorganozinc compound to said aldehyde in the presence of a first catalyst to form an allylic alkoxide compound; and (b) epoxidizing said allylic alkoxide compound in the presence of an oxidant and a second catalyst.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Synthesis Of Substituted Cis-8,Cis-11,Cis-14-Eicosatrienoic Acids, Precursors Of Correspondingly Substituted Prostaglandins
    作者:L. Heslinga,R. Van Der Linde,H. J. J. Pabon,D. A. Van Dorp
    摘要:C-14-Eicosatrienoic Acid. They Were Obtained Via Coupling Of (A) C-7,C-10,C-13-Nonadecatrien-2-One With Ethoxycarbonylmethylenetriphenylphosphorane And C-7,C-10,C-13-Nonadecatrien-2-Yl Methane Sulfonate With Diethyl Malonate, (B) L-Bromo-C-2,C-5,C-8-Tetradecatriene With 5-Hexynoic Acid, (C) 1-Bromo-2,5-Undecadiyne With The Appropriately Substituted 8-Nonynoic Acids And (D) From The Correspondingly Substituted 1-Bromo

    合成参考文献


    摘要:Alonso, D. A.; Nájera, C., Science of Synthesis, (2010) 47, 461.
    摘要:Tobe, Y.; Takeda, T., Science of Synthesis, (2010) 45, 1336.
    摘要:Vaultier, M.; Pucheault, M., Science of Synthesis Knowledge Updates, (2012) 4, 313.
    摘要:Hlina, J. A., Science of Synthesis Knowledge Updates, (2021) 1, 127.
    摘要:Anderson, E. A.; Lim, D. S. W., Science of Synthesis Knowledge Updates, (2015) 1, 65.
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