CAS: 102691-36-1; 3-((Bis(Diisopropylamino)Phosphino)Oxy)Propanenitrile

相似化合物

102690-88-0 137348-88-0 108549-21-9

上下游产品

CAS号76101-30-9 2-氰基乙基二氯亚磷酸酯 | CAS号108-18-9 二异丙胺 | CAS号109-78-4 3-羟基丙腈 | CAS号56183-63-2 双(二异丙基氨基)氯膦 | CAS号7719-12-2 三氯化磷 | CAS号146691-59-0 6-thio-dg cep | CAS号142103-12-6 3'-脱氧-5'-O-DMT-... | CAS号207347-42-0 N6-Bz-5'-O-DMTr... | CAS号98796-51-1 DMT-dT亚磷酰胺单体 | CAS号98796-53-3 DMT-dA(bz)亚磷酰胺单体 | CAS号157327-96-3 N-苯甲酰基-5'-O-[二(... | CAS号104992-55-4 N-苯甲酰基-5'-O-(4,... | CAS号102690-88-0 双(2-氰乙基)-N,N-二异... | CAS号134031-86-0 2'-OMe-U亚磷酰胺单体 | CAS号330628-04-1 DMT-dG(dmf) 亚磷酸酰胺

二异丙胺置于三乙胺,三氯化磷体系中,用 乙醚 用作溶剂,化学反应 12.0H,反应生成双(二异丙基氨基)(2-氰基乙氧基)膦
参考文献:New Approach To The Synthesis Of Deoxyribonucleoside Phosphoramidite Derivatives
标题:New Approach To The Synthesis Of Deoxyribonucleoside Phosphoramidite Derivatives
摘要:在磷上具有各种保护基团的脱氧核糖核苷磷酰胺,以双(二异丙基氨基)氯膦作为新的磷酰化剂,无需分离双(二异丙基氨基)烷氧基膦,即可在一锅反应中快速制备,且收率非常好.
Doi:10.1246/cl.1986.1401

专利信息

专利号:US-2025313590-A1
优先权日:2024-03-16
标题:Phosphoramidite morpholino monomers towards synthesis/convergent synthesis of PMO, TMO, their chimera oligos in 5 prime to 3 prime direction
发明人：SINHA SURAJIT; GHOSH ATANU; BANERJEE ARPAN
权利人:INDIAN ASS FOR THE CULTIVATION OF SCIENCE
摘要:The present invention relates to 5′-morpholino amidite monomers as 5′-CE/5′- t Bu phosphoramidite morpholino monomers (2) and process chemistry for the efficient synthesis of N-Trityl or monomethoxytrityl (MMTr)-protected 5′-morpholino amidite monomers and their use in the synthesis of phosphorodiamidate morpholino oligonucleotides (PMO), thiophosphoramidate morpholino oligonucleotides (TMO) and their chimeras which can be used for antisense technology or in general oligonucleotides related research.

专利号:EP-0422090-B1
优先权日:1988-06-20
标 题:Derivatives of nucleosides which may be used for the synthesis of marked oligonucleotides, and oligonucleotides obtained from these derivatives and their synthesis
摘要:A nucleoside derivative which may be used for the synthesis of oligonucleotides of the formula (I), in which: R1 represents a hydrogen atom or an unstable radical in an acid medium suitable for nucleotide synthesis; R2 represents a hydrogen atom or a protective radical, a functional radical or a support which may be used for nucleotide synthesis; R3 represents a hydrogen atom, the hydroxyl radical or a protected hydroxyl radical; and B represents a radical derived from a puric or pyrimidic base comprising an exocyclic NH2 group substituted by an R4Z group where R4 represents a single bond or a hydrocarbonated radical and Z is a marker element.

专利号:US-6531591-B1
优先权日:1999-07-07
标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
发明人：FENSHOLDT JEF
权利人:EXIQON AS
摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.

专利号:US-11938187-B2
优先权日:2021-06-10
标题:Methods and compositions for synthesis of two-photon cleavable phosphoramidite molecules for oligonucleotide conjugation
发明人：LO PEGGY PIK KWAN; LIU LING SUM; TAM DICK YAN
权利人:UNIV CITY HONG KONG
摘要:The syntheses of two phosphoramidite building blocks based on BNSF and BNSMB structures are disclosed. Furthermore, some common molecular intermediates have been designed and linked to the central biphenyl core of the two molecules, resulting in a versatile and cost-effective design. These compounds can be effectively introduced to DNA oligonucleotides via the well-established standard cyanoethylphosphoramidite chemistry on the nucleic acid synthesizer. Fragmentation of these BNSF- and BNSMB-functionalized DNA strands is achieved by both one-photon and two-photon photolysis of photoliable bonds of [2-(2-nitrophenyl)propoxy]carbonyl groups on BNSF and BNSMB molecules respectively, resulting in two short pieces of single-stranded DNAs. The versatile design and facile synthesis of these two-photon photocleavage phosphoramidite molecules are beneficial to synthetic chemists and photochemists for the development of new caged compounds which enables to introduce into oligonucleotides as light-triggered carriers via solid-phase synthesis for a wide range of applications in materials science, polymer, chemistry, biology and DNA nanoecthnology.

专利号:US-2004152905-A1
优先权日:2003-01-31
标题:Universal building blocks and support media for synthesis of oligonucleotides and their analogs
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and chemically modified oligonucleotide analogs, are provided. In addition, methods for functionalization of a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:EP-1202998-B1
优先权日:1999-07-07
标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates
发明人：FENSHOLDT JEF
权利人:EXIQON AS
摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.