CAS: 1003-68-5; 5-Methylpyridin-2(1H)-One

相似化合物

1003-56-1 94805-52-4 106984-91-2

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4-Formyl-2-Pentenonitrile置于对甲苯磺酸体系中,化学反应生成2-羟基-5-甲基嘧啶
参考文献:Synthesis Of 2-Substituted-5-Methylpyridines From
标题:Synthesis Of 2-Substituted-5-Methylpyridines From
摘要:3-甲基-2-烷基胺基-1-卤代-1-氰基环丁烷在酸性条件下被裂解,形成2-卤代-4-甲酰基戊腈和4-甲酰基-2-戊烯腈,可以通过环化反应形成2-取代-5-甲基吡啶衍生物.这些吡啶衍生物可作为制造除草剂如氟草酯丁酯的起始材料.

专利信息

专利号:US-10011567-B1
优先权日:2017-03-09
标题 :Method for the synthesis of acrylate derivatives
发明人：WANG MINGWEN; ZHANG YUE
权利人:INNOSCI LLC
摘要:The present invention provides an improved synthesis of a salt of acrylate derivatives. The synthesis generally includes the preparation of an ester or an amide containing a leaving group followed by the formation of a salt.

专利号:WO-2025122636-A1
优先权日:2023-12-04
标题:Method for the synthesis of acrylate derivatives
发明人：CAICEDO-CARVAJAL CARLOS; KATZ JORDAN; CHOI SEAN
权利人:ORTHOBOND CORP
摘要:The disclosure relates to the synthesis of quaternary salts of various acrylates in high yield and high purity.

专利号:US-12331021-B2
优先权日:2020-09-10
标题 :Total synthesis of pirfenidone
发明人：ZHOU LIHUA
权利人:SUZHOU FUDE ZHAOFENG BIOCHEMICAL TECH CO LTD
摘要:The present invention relates to a process for the synthesis of Pirfenidone (1) from 5-Methyl-3,4-dihydro-2-pyridone and halobenzene (chlorobenzene, bromobenzene, or iodobenzene) in the presence of a catalytic system consisting of a copper salt and an organic ligand, in the presence of a base.

专利号:US-10472325-B2
优先权日:2015-10-29
标题:Process for the synthesis of pirfenidone
发明人：MOSSOTTI MATTEO; BAROZZA ALESSANDRO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:Disclosed is a process for the synthesis of Pirfenidone (1) from 5-methyl-2(1H)-pyridinone and chlorobenzene in the presence of a catalytic system consisting of a copper salt and an organic ligand, in the presence of a base. n n n n n n n n n n The process exploits the high efficiency of the catalytic system consisting of copper(I) salt and an organic ligand in the presence of an inorganic base in the N-amidation reaction of chlorobenzene, a cheap reagent also usable as solvent in this case; reaction conditions at high temperatures, at atmosphere pressure or higher, produce a reaction with good yields.

专利号:US-4658031-A
优先权日:1982-10-07
标 题:Synthesis of 2-substituted-5-methyl-pyridines and intermediates therefor
发明人：HARTMANN LUDWIG A; STEPHEN JOHN F
权利人:ICI AMERICA INC
摘要:A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicies as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two readily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.

专利号:US-4515952-A
优先权日:1982-03-25
标 题 :Synthesis of 2-pyridylalkylamines substituted on the pyridyl ring by bromine
发明人：ADGER BRIAN M; O'ROURKE DAVID J
权利人:SMITH KLINE FRENCH LAB
摘要:The invention provides a process for preparing 2-pyridylalkylamines, substituted in one of the 3- or 5-positions by bromo and in the other by C 1-4 alkyl, by reacting an appropriate C 1-4 alkyl substituted 2-pyridylalkylamine with an electrophilic brominating agent. Said 2-pyridylalkylamines are useful as intermediates in the synthesis of compounds useful as histamine H 1 -antagonists.