CAS: 952518-97-7; 4-(1H-Pyrazol-4-yl)-7H-Pyrrolo[2,3-D]Pyrimidine
该化合物是一种环球化合物,其组成为一个有阳极球替代成分的火球杆菌芯,该化合物在药用化学和药物发现中具有很大的多功能性,特别是作为关键中间或脚架,用于活性抑制剂和其他生物活性分子.其僵硬的平板结构增强了对蛋白物的粘合性,而阳极醇运动则提供了其他功能化场所,使改良的药用植物特性能够有针对性地修改.该化合物的高度纯度和稳定性使它适合严格的合成应用.其在肿瘤学和炎症研究中的重要性突出它作为开发新型治疗剂的有价值的建筑材料的效用.
相似化合物
1803583-30-3 1203569-59-8 28648-87-5MSDS等安全信息
上下游产品
tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylate 4-chloro-1H-pyrrolo[2,3-d]pyrimidine合成工艺路线路线简述
- 1187594-09-7 = 952518-97-7
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; Rt -> 90 °C; 1 H,90 °C; 90 °C -> Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Basified
标题:Preparation Of 4- (1H-Pyrazole-4-Yl) -7H-Pyrrole [2,3-D] Pyrimidine
参考文献:China]
3680-69-1 + 552846-17-0 = 952518-97-7
反应条件:1.1 Reagents: Sodium Carbonate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane,Water; 2 H,Rt -> 100 °C
标题:Preparation Of Small Molecule Compounds
参考文献:World Intellectual Property Organization]
3680-69-1 + 552846-17-0 = 952518-97-7
反应条件:1.1 Reagents: Sodium Carbonate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane,Water; 2 H,Rt -> 100 °C
标题:Small Molecule Compound,Preparation And Application In Preparation Of Medicine For Alleviating Autoimmune And Allergic Diseases Thereof
参考文献:China]
2222825-69-4 = 952518-97-7
反应条件:1.1 Reagents: Sodium Ethoxide
标题:Preparation Method Of (7R)-4-(1H-Pyrazol-4-Yl)-7H-Pyrrolo[2,3-D]Pyrimidine As Key Intermediate Of Baricitinib For Treating Rheumatoid Arthritis
参考文献:China]
= 952518-97-7 [标题:Reaction Conditions
标题:Preparation Of Deazapurines As Inhibitors Of Janus Kinases (Jak).
参考文献:World Intellectual Property Organization
📜Barictinib置于盐酸体系中,用 水 作为反应溶剂,化学反应 1.0H,以81%的收率获得产物4-{7H-吡咯并[2,3-D]嘧啶-4-基}-1H-吡唑
参考文献:4-(1H-吡唑-4-基)-7H-吡咯[2,3-D]嘧啶的制备
标题:4-(1H-吡唑-4-基)-7H-吡咯[2,3-D]嘧啶的制备
摘要:本发明涉及4‑(1H‑吡唑‑4‑基)‑7H‑吡咯[2,3‑d]嘧啶的制备.具体为1‑(乙基磺酰基)‑3‑[4‑(7H‑吡咯并[2,3‑d]嘧啶‑4‑基)‑1H‑吡唑‑1‑基]‑3‑氮杂环丁烷乙腈在酸作用下发生化学反应,实现4‑(1H‑吡唑‑4‑基)‑7H‑吡咯[2,3‑d]嘧啶的制备.
专利信息
专利号:WO-2016183060-A1
优先权日:2015-05-11
标 题:Process for the synthesis of a phosphoinositide 3-kinase inhibitor
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1007/s10593-012-0986-2
摘要:Tumkevicius S, Dodonova J. Functionalization of pyrrolo[2,3-d]pyrimidine by palladium-catalyzed cross-coupling reactions (review). Chemistry of Heterocyclic Compounds. 2012 May;48(2):258–79. doi: 10.1007/s10593-012-0986-2.
📝 需求与反馈
尽可能描述清楚需求与问题信息
