CAS: 942947-94-6; 5-Bromo-4-Chloropyridin-2-Amine

• 英文名称5-Bromo-4-Chloropyridin-2-Amine
• 中文名称2-氨基-4-氯-5-溴吡啶
• IUPAC名称5-bromo-4-chloropyridin-2-amine
• 其它别名2-氨基-5-溴-4-氯吡啶; 5-Bromo-4-Chloropyridin-2-Amine
• CAS编号942947-94-6
• MFCD编号:MFCD12407282
• EINECS号:807-141-4
• FDA UNII编号:S5NXK6YT42
• 分子式:C5H4BrClN2
• 分子量:207.46
• 产品CID: 1992928
• 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

• 相似结构搜索
• InChIKey: DDOFUMWLNSICHU-UHFFFAOYSA-N
• InChI=1S/C5H4BrClN2/c6-3-2-9-5(8)1-4(3)7/h1-2H,(H2,8,9)…
• 计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数0.0

相似化合物

物理性质

• 熔点141-147 °C
• 沸点271.5°C at 760 mmHg
• 闪点118.0±25.9 °C
• 密度1.8±0.1 g/cm3
• pKa:3.61±0.24(预测)
• PSA:38.91
• LogP:2.0797
• 折射率1.648
• 蒸汽压0.0±0.6 mmHg at 25°C
• 外观形态淡米色粉末
• 储存条件在惰性气体(氮气或氩气)下 2–8 °C
• 产品应用该化合物是在合成各种药物时广泛应用的重要药品中间体,由于其分子量低和独特的结构,可衍生成各种下游产品,具有广泛的效用.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别急性毒性 类别4(经口)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2A
  急性毒性 类别4(吸入)
  急性毒性 类别4(经皮)
  严重眼刺激 类别2
• 警示词Warning(警告)
• 危险描述H302 |吞咽有害.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H332 |吸入有害.
  H312 |皮肤接触有害.
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

欧盟法规

上下游产品

合成工艺路线路线简述

• 19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; Rt; 16 H,Rt
  标题:Preparation Of Oxodihydropyridine Derivatives And Analogs For Use As Bromodomain Inhibitors
  参考文献:World Intellectual Property Organization]
  
  19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; Rt; 14 H,Rt
  标题:Preparation Of Aryl Lactam Kinase Inhibitors Useful In Inhibiting Aak1
  参考文献:United States]
  
  19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: Acetic Acid Solvents: Tetrahydrofuran; Rt -> 0 °C1.2 Reagents: N-Bromosuccinimide Solvents: Tetrahydrofuran; 1.5 H,0 - 10 °C; 2 H,0 - 10 °C1.3 Reagents: Sodium Hydroxide Solvents: Toluene,Water
  标题:Processe To Make Protein Kinase Inhibitor N-[4-[4-Amino-7-[1-(2-Hydroxyethyl)-1H-Pyrazol-4-Yl]Thieno[3,2-C]Pyridin-3-Yl]Phenyl]-N'-(3-Fluorophenyl)Urea
  参考文献:World Intellectual Property Organization]
  
  19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Dichloromethane; 0 °C; 30 Min
  标题:A Process For Preparing 5-Bromo-2,4-Dichloro-Pyridine From 4-Chloro-2-Pyridinamine
  参考文献:China]
  
  19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 6 H,Rt
  标题:Synthesis Of Hpk1 Degrader Anticancer Agents
  参考文献:World Intellectual Property Organization]
  
  19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 3 H,Rt
  标题:Preparation Of 2-Aminopyridine Compounds Useful In Treating Hyperproliferative Diseases
  参考文献:World Intellectual Property Organization]
  
  19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; Rt; 16 H,Rt
  标题:Imidazo[4,5-B]Pyridine Derivatives As Inhibitors Of Aurora Kinases: Lead Optimization Studies Toward The Identification Of An Orally Bioavailable Preclinical Development Candidate
  作者:Bavetsias,Vassilios; Large,Jonathan M.; Sun,Chongbo; Bouloc,Nathalie; Kosmopoulou,Magda; Et Al
  参考文献:Journal Of Medicinal Chemistry 日期:2010 卷标:53(14) 页码:5213-5228]
  
  19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; Rt; 16 H,Rt
  标题:Preparation Of Imidazopyridines As Enzyme Inhibitors,Especially Aurora Kinase Inhibitors,For Treating Cell Proliferative Diseases
  参考文献:World Intellectual Property Organization]
  
  19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 12 H,Rt
  标题:Imidazopyridine Derivative And Pharmaceutical Composition Comprising Same As Active Ingredient
  参考文献:Korea]
  
  19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; Rt; 14 H,Rt
  标题:Preparation Of Chromenopyridine Derivatives For Use As Adaptor Associated Kinase 1 Inhibitors
  参考文献:World Intellectual Property Organization]
  
  19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 14 H,Rt
  标题:Preparation Of Chromenopyridinyloxyalkylamine Derivatives For Use As Adaptor Associated Kinase 1 Inhibitors
  参考文献:World Intellectual Property Organization]
  
  19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: Tetrabutylammonium Bromide,Lithium Perchlorate Solvents: Acetic Acid,Acetonitrile; 16 H,25 °C
  标题:Electrochemical Synthesis Method Of Bromopyridine Derivatives
  参考文献:China]
  
  19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 3 H,Rt
  标题:Discovery Of Potent,Selective,And Orally Bioavailable Small-Molecule Modulators Of The Mediator Complex-Associated Kinases Cdk8 And Cdk19
  作者:Mallinger,Aurelie; Schiemann,Kai; Rink,Christian; Stieber,Frank; Calderini,Michel; Et Al
  参考文献:Journal Of Medicinal Chemistry 日期:2016 卷标:59(3) 页码:1078-1101]
  
  19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: Bromine Solvents: Acetonitrile; 30 Min,0 °C; 0 °C -> Rt; Overnight,Rt
  标题:Tricyclic Pyridocarboxamide Derivatives As Rock Inhibitors And Their Preparation
  参考文献:World Intellectual Property Organization]
  
  19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile
  标题:Imidazo[1,2-A]Pyridine Compounds As Tyrosine Kinase C-Met Signal Transduction Pathway Inhibitors And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Cell Hyperplasia Diseases
  参考文献:World Intellectual Property Organization]
  
  19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile
  标题:Preparation Of Chromenopyridine Derivatives For Use As Aak1 Inhibitors
  参考文献:World Intellectual Property Organization]
  
  19798-80-2 = 942947-94-6
  反应条件:1.1 Reagents: Tetrabutylammonium Bromide,Lithium Perchlorate Solvents: Acetic Acid,Acetonitrile; 8 H,25 °C
  标题:Directing Group Enables Electrochemical Selectively Meta-Bromination Of Pyridines Under Mild Conditions
  作者:Wu,Yanwei; Xu,Shanghui; Wang,Hong; Shao,Dongxu; Qi,Qiqi; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2021 卷标:86(22) 页码:16144-16150

海关参考信息

• 2933310010-吡啶
  2939800000-其他生物碱
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
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• ➥ REACH监管