CAS: 933702-55-7; 2-Chloropyrimidine-5-Carbaldehyde

该化合物是一种七环有机化合物,其特点是以氯原子和甲酰胺功能组组成一个以铁环替代的火水环,其分子结构有助于其潜在的生物活动,使其对药用化学具有兴趣.此外,2-Chloropyrimidine-5-carbaldhyde可以参与各种化学反应,包括核分裂性添加和凝聚反应,进一步扩大其在合成化学中的效用.应当参考安全数据,因为卤化化合物可能对健康造成风险.

结构式图片

相似化合物

1753-50-0 89793-12-4 374068-01-6

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

5-Bromo-2-chloropyrimidine formic acid ethyl ester 2-chloro-4-vinylpyrimidine 2-chloro-5-hydroxymethyl-pyrimidine 4-(4,4-difluor°Cyclohexyl)-3-{fluoro[4-(trifluoromethyl)phenyl]methyl}-2-[1-(5-formylpyrimidin-2-yl)piperidin-4-yl]-5-[(4-methoxybenzyl)oxy]-7,7-dimethyl-5,6,7,8-tetrahydroquinoline 2-N,N-Dimethylaminopyrimidine-5-carboxaldehyde 2-(4-((1R,2R)-2-(((2-fluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)pyrimidine-5-carbaldehyde (2-(4-((1R,2R)-2-(((2-fluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidin-1-yl)pyrimidin-5-yl)methanol

合成工艺路线路线简述

  • 合成目标产物 2-Chloropyrimidine-5-Carbaldehyde 主要起始原料 5-Pyrimidinecarboxaldehyde, 1,2-Dihydro-2-Oxo- (9CI)
  • 166757-62-6 = 933702-55-7
    反应条件:1.1 Reagents: Diisopropylethylamine,Phosphorus Oxychloride Solvents: Acetonitrile; 0 °C; 0 °C -> 80 °C; 6 H,80 °C
    标题:Preparation Method Of 2-Chloro-Pyrimidine-5-Carbaldehyde With Stable Reaction Process
    参考文献:China]

    1046816-75-4 = 933702-55-7
    反应条件:1.1 Reagents: Manganese Oxide (Mno2) Solvents: Dichloromethane; Rt; 4 H,40 °C
    标题:Thiazolidinediones And Related Compounds As Cgas Antagonists And Their Preparation
    参考文献:World Intellectual Property Organization]

    131467-06-6 = 933702-55-7
    反应条件:1.1 Reagents: 2,6-Lutidine,Sodium Periodate Catalysts: Osmium Tetroxide Solvents: 1,4-Dioxane,Water; 2 - 3 H,Rt1.2 Reagents: Water Solvents: Ethyl Acetate; Rt
    标题:Preparation Of N-Aryl And N-Heteroaryl Acrylamides As Fgfr4 Inhibitors
    参考文献:World Intellectual Property Organization]

    109-94-4 + 32779-36-5 = 933702-55-7
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran
    标题:Preparation Of Small Molecules And Aminoalkyl Benzenoanthracene Carboxamide Compounds For Treating Rna-Mediated Diseases
    参考文献:World Intellectual Property Organization]

    166757-62-6 = 933702-55-7
    反应条件:1.1 Reagents: N,N-Dimethylaniline,Phosphorus Oxychloride Solvents: Acetonitrile; Rt -> 80 °C; 4 H,Reflux
    标题:Method For Preparing 2-Chloropyrimidine-5-Carbaldehyde
    参考文献:China]

    16919-18-9 + 29671-92-9 + 2367013-83-8 = 933702-55-7
    反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Methanol,Water; Rt -> 50 °C; 6 H,50 °C
    标题:Preparation Of 2-Chloro-5-Formylpyrimidine
    参考文献:China]

    109-94-4 + 32779-36-5 = 933702-55-7
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; Rt; Rt -> -78 °C1.2 Reagents: Hydrochloric Acid Solvents: Ethyl Acetate1.3 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized
    标题:Self-Replication And Amplification Of Enantiomeric Excess Of Chiral Multifunctionalized Large Molecules By Asymmetric Autocatalysis
    作者:Kawasaki,Tsuneomi; Nakaoda,Mai; Takahashi,Yutaro; Kanto,Yusuke; Kuruhara,Nanako; Et Al
    参考文献:Angewandte Chemie 日期:2014 卷标:53(42) 页码:11199-11202]

    109-94-4 + 32779-36-5 = 933702-55-7
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 2 H,-100 °C
    标题:Design And Synthesis Of Diazine-Based Panobinostat Analogues For Hdac8 Inhibition
    作者:Balasubramaniam,Sivaraman; Vijayan,Sajith; Goldman,Liam V.; May,Xavier A.; Dodson,Kyra; Et Al
    参考文献:Beilstein Journal Of Organic Chemistry 日期:2020 卷标:16 页码:628-637]

    109-94-4 + 32779-36-5 = 933702-55-7
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran
    标题:Nucleic Acid-Binding Photoprobes And Uses Thereof For Identifying Rna Transcripts And Screening Drug Candidates
    参考文献:World Intellectual Property Organization]

    109-94-4 + 32779-36-5 = 933702-55-7
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran
    标题:Preparation Of Trisaccharides And Aminoalkyl Benzenoanthracene Carboxamide Compounds And Methods Of Treating Rna-Mediated Diseases
    参考文献:World Intellectual Property Organization
📜(2-氯嘧啶-5-基)甲醇置于manganese(Iv) Oxide体系中,用 二氯甲烷 作为反应溶剂,化学反应 4.0H,反应生成 2-氯嘧啶-5-甲醛
参考文献: Cgas Antagonist Compounds[fr] Composés Antagonistes Du Cgas
标题: Cgas Antagonist Compounds[fr] Composés Antagonistes Du Cgas
摘要:揭示了一种新型化合物的化学式(i),这些化合物是cgas拮抗剂,涉及到这些化合物的制备方法,包含这些化合物的药物组合物,以及它们在医学治疗中的应用.

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专利信息


专利号:WO-2025128873-A1
优先权日:2023-12-12
标题:Heterocyclic pyridinone compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:CN-109651424-A
优先权日:2017-10-11
标题:A simple method for the synthesis of 7-protecting group-4-(1-hydro-pyrazol-4-yl)pyrro[2,3-d]pyrimidine

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