CAS: 933-40-4; 1,1-Dimethoxycyclohexane

该化合物其结构特征为从环己酮中衍生出来的胎儿,典型的是一种无色黄色的浅色液体,有舒适的气味;该化合物以水中的挥发性和中度溶解性相对较低而闻名,同时在乙醇和乙醚等有机溶剂中更易溶解;Cyclohexanone dimecon ketal主要用作溶剂和有机合成的中间体,特别是在生产各种化学化合物时;其化学稳定性和再活性使其在化学反应中的聚合和再剂应用中有用;安全考虑包括在通风良好的地区处理该化合物,并使用适当的个人防护设备,因为它可能对吸入或皮肤接触造成健康风险;

结构式图片

相似化合物

758716-89-1 10553-38-5 112906-44-2

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号108-94-1 环己酮 | CAS号149-73-5 原甲酸三甲酯 | CAS号122-51-0 原甲酸三乙酯 | CAS号504-63-2 1,3-丙二醇 | CAS号1825-61-2 甲氧基三甲基硅烷 | CAS号67-56-1 甲醇 | CAS号109-87-5 甲缩醛 | CAS号6651-36-1 1-环己烯氧基三甲基硅烷 | CAS号110-83-8 环己烯 | CAS号108-95-2 苯酚 | CAS号107679-90-3 1-[[(4S,5R)-4-(... | CAS号4423-79-4 2,2-五亚甲基-1,3-二氧... | CAS号1825-61-2 甲氧基三甲基硅烷 | CAS号108-94-1 环己酮 | CAS号74-88-4 碘甲烷 | CAS号2699-12-9 Hydroperoxide,1... | CAS号2699-11-8 cyclohexylidene... | CAS号89423-39-2 (1-methoxycyclo... | CAS号67-56-1 甲醇 | CAS号931-56-6 甲氧基环己烷

合成工艺路线路线简述

  • 合成目标产物 1,1-Dimethoxycyclohexane 主要起始原料 Cyclohexanone And Triethyl Orthoformate And 1,3-Propanediol
  • (文献来源)合成步骤主要原料 Cyclohexanone 和 Triethyl Orthoformate 和 1,3-Propanediol
1-Methoxybicyclo-<3.1.0>-Hexan置于4,4'-联苯甲腈体系中,用 甲醇 作为反应溶剂,化学反应生成 环己酮二甲缩酮
参考文献:Ring Expansions Via Photoinduced Single Electron Transfer Promoted Opening Of Cyclopropyl Ethers
标题:Ring Expansions Via Photoinduced Single Electron Transfer Promoted Opening Of Cyclopropyl Ethers
摘要:
DOI:10.1021/jo00258A044

海关参考信息

专利信息


专利号:US-7358382-B2
优先权日:2001-08-03
标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production
发明人:WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the production of epothilones or epothilone derivatives.

专利号:US-7368568-B2
优先权日:2001-08-03
标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use
发明人:WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroarnides for the synthesis of edothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

专利号:US-6933385-B2
优先权日:2001-08-03
标题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use
发明人:WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:SCHERING AG
摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

专利号:US-10717718-B2
优先权日:2015-11-17
标 题:5-azido-5-deoxy-2 :3-isopropylidene-D-arabinose compounds; their method of manufacture and their use for the synthesis of ARA-N3, KDO-N3 and 4EKDO-N3
发明人:VAUZEILLES BORIS; MAS PONS JORDI; BARON AURÈLIE
权利人:CENTRE NAT RECH SCIENT
摘要:Disclosed are new compounds of formulae: n nWherein: R 1 and R 2 can be independently H; a C 1 to C 6 alkyl including methyl, ethyl, propyl, butyl; aryl including phenyl, para-methoxyphenyl; or R 1 ,R 2 together with the carbon C-6 can be a cyclopentylidene or cyclohexylidene; each of these groups being substituted or not; and R 3 can be a C 1 to C 6 alkyl including methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl; or aryl including phenyl, methylphenyl, ethylphenyl, each of these groups being substituted or not. The invention also relates to their method of manufacture and their use for the synthesis of Ara-N 3 , Kdo-N 3 and 4eKdo-N 3 .

专利号:WO-0172706-A1
优先权日:2000-03-28
标题 :Synthesis of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)
发明人:SAMBASIVAN GANESH; SRIDHARAN MADHAVAN; PADUDEVASTANA SATHYASHANKER; POORNAPRAJNA ACHARYA; MATHEW JOY; SRINATH SUMITHRA; NAIR SATHEESH
权利人:BIOCON LTD; SAMBASIVAN GANESH; SRIDHARAN MADHAVAN; PADUDEVASTANA SATHYASHANKER; POORNAPRAJNA ACHARYA; MATHEW JOY; SRINATH SUMITHRA; NAIR SATHEESH
摘要:The present invention discusses a novel process for the synthesis of [R-(R*,R*)]-2-(4-fluorophenyl)-B,D-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt by using 4-fluoro-α-[2-methyl-1-oxopropyl]η-oxo-N-β-diphenylbenzene butaneamide with (4R)-methyl 6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-3-acetate. The compound so prepared is useful as inhibitors of the enzyme HMG-CoA reductase and are thus used as hypolipidemic and hypocholesterolemic agents.

专利号:US-6518438-B2
优先权日:1996-08-23
标题:Preparation of cyclohexene carboxylate derivatives
发明人:KENT KENNETH M; KIM CHOUNG U; MCGEE LAWRENCE R; MUNGER JOHN D; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; KELLY DAPHNE E; WILLIAMS MATTHEW A; ZHANG LIJUN
权利人:GILEAD SCIENCES INC
摘要:The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.
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主要参考文献

[参考文献]: M Ogata, Et Al. Synthesis And Oral Antifungal Activity Of Novel Azolylpropanolones And Related Compounds. J Med Chem. 1987 Jun;30(6):1054-68.

合成参考文献


摘要:Vil’, V. A.; Bityukov, O. V.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2019) 3, 420.
摘要:Vil’, V. A.; Bityukov, O. V.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2019) 3, 389.
摘要:Vil’, V. A.; Bityukov, O. V.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2019) 3, 408.
参考文献:10.1038/ncomms14190
摘要:Meng Q, Hou M, Liu H, Song J, Han B. Synthesis of ketones from biomass-derived feedstock. Nature Communications. 2017 Jan 31;8(1):14190. doi: 10.1038/ncomms14190.
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