专利号:WO-2024076306-A1 优先权日:2022-10-05 标题:Micro-flow synthesis of compounds and systems thereof 发明人:WU JIE; LIU CHENGUANG; WANG MU 权利人:NAT UNIV SINGAPORE 摘要:The present disclosure concerns a micro-flow system for synthesis of a compound, comprising a tubing reactor configured to flow a reactant within its lumen thereof, an actuator for regulating the flow of the reactant in the lumen and a heterogeneous catalyst in fluid communication with the lumen. The present disclosure also concerns a method of micro-flow synthesising a compound using the micro-flow system.
专利号:US-2024082118-A1 优先权日:2021-05-19 标 题:Topical compositions and methods of preparing the same 发明人:ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION 权利人:LANDA LABS 2012 LTD 摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.
专利号:US-2004053999-A1 优先权日:1997-09-17 标题 :Novel compounds and methods for synthesis and therapy 发明人:BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A 摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
专利号:US-10526593-B2 优先权日:2015-07-09 标 题 :Method for obtaining a composition for biomass hydrolysis 发明人:YAZDANI SYED SHAMS; OGUNMOLU FUNSO EMMANUEL 权利人:INT CENTRE FOR GENETIC ENGINEERING & BIOTECHNOLOGY; DEPARTMENT OF BIOTECH MINISTRY OF SCIENCE & TECH 摘要:The present invention discloses a composition for biomass hydrolysis. The components of the composition may be obtained by biological or synthetic means. Synthetically, the components of the composition of the present invention may be obtained by amino acid synthesis or may be procured commercially.
专利号:US-10278395-B2 优先权日:2013-03-11 标 题 :Functionalized environmentally benign nanoparticles 发明人:VELEV ORLIN D; RICHTER ALEXANDER P 权利人:UNIV NORTH CAROLINA STATE 摘要:This invention is directed to the preparation and applications of internally and/or externally functionalized environmentally benign nanoparticles (EbNPs), which are produced by a three step procedure: (1) synthesis of native EbNPs, (2) functionalization with active agents, and (3) additional surface property customization via one or more modifier(s).
专利号:US-6998259-B1 优先权日:1999-05-20 标题:Enzymatic treatment of whey proteins for the production of antihypertensive peptides and the resulting products 发明人:DAVIS MARTIN E; RAO ANAND; GAUTHIER SYLVIE; POULIOT YVES; GOURLEY LINE; ALLAIN ANNE-FRANCOISE 权利人:DAVISCO FOODS INTERNAT 摘要:Enzymatic digests of whey protein concentrates were prepared using animal, bacterial and fungal proteases, and evaluated for antihypertensive activities. The highest ACE-inhibitory activity was obtained with the purified peptide β-1g (f142–148) obtained by chemical synthesis, for which an IC 50 value of 0.04 mg powder.ml −1 was found. The hydrolysates derived from BiPROâ„¢ whey protein isolate and β-1g both gave higher antihypertensive activities (IC 50 values of 0.29 to 0.90 mg powder.ml −1 ) than the other hydrolysates tested (IC 50 values of 0.96 and 1.30 mg powder.ml −1 ). The recovered hydrolysate can be used to treat hypertension in mammals such as humans and domestic pets such as dogs and cats.
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合成参考文献
摘要:Compound: 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (2:1)