CAS: 68194-07-0; 2,2',3,4',5-Pentachlorobiphenyl

该化合物是一种氯化双苯化合物,具有明确的分子结构,由于其稳定性和化学特性,通常用于研究和工业应用.作为多氯二苯(PCB)家族的成员,它作为环境和毒理学研究的参考标准,协助分析多氯联苯污染和降解路径.其特征完善的结构使得能够精确校准色谱和光谱技术.该化合物的持久性和可预见的行为使得研究生物累积性和环境归宿具有价值.由于国际化学品安全准则对它的潜在毒性和监管限制,需要严格的处理协议.

英文名称2,2',3,4',5-Pentachlorobiphenyl
中文名称2,2’,3,4’,5-戊氯联苯
IUPAC名称1,2,5-trichloro-3-(2,4-dichlorophenyl)benzene
其它别名PCB NO 90; 2,2',3,4',5-PENTACHLOROBIPHENYL; PCB-90
CAS编号68194-07-0
MFCD编号:MFCD00661145
FDA UNII编号:C9Y9KD49DF
分子式:C12H5Cl5分子量:326.43
产品CID: 1670736
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
产品信息参考;;;;
InChIKey: SUOAMBOBSWRMNQ-UHFFFAOYSA-N
1S/C12H5Cl5/c13-6-1-2-8(10(15)4-6)9-3-7(14)5-11(16)12(9)17/h1-5H
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

2,3,5-trichloroaniline 1,3-Dichlorobenzene

合成工艺路线路线简述

📜三氯苯胺,1,3-二氯苯置于sodium Acetate,亚硝酸体系中,化学反应生成 2,2',3,4',5-戊氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4