CAS: 5966-41-6; Diisopromine

该化合物是一种化学化合物,属于被称为氨的有机化合物类别,其特点是氮原子中有两个异丙基组,这有其独特性.二苯基一般没有色素,可粉黄,有独特的气味;有机溶剂中可溶解,但由于其缺水异丙基组,水溶解性有限.复合物质具有典型的基本特性,允许它参与各种化学反应,包括碱和细胞.二苯丙胺在制药工业中应用,特别是作为合成其他化学化合物的中间体.安全数据表明,与许多氨一样,应谨慎处理,因为对皮肤和呼吸系统有潜在的刺激作用.建议采取适当的安全措施,包括使用个人防护设备.

英文名称Diisopromine
中文名称地索普明
IUPAC名称N,N-diisopropyl-3,3-diphenylpropan-1-amine
其它别名Propylamine,N,N-diisopropyl-3,3-diphenyl- (6CI,7CI,8CI); Cholagol; Diisopromine; Dispromine; Do-Bil; Hepabyl; Hepacol; Megabyl; N,N-Diisopropyl-3,3-diphenylpropylamine
CAS编号5966-41-6
MFCD编号:MFCD00865196
EINECS号:227-752-4
FDA UNII编号:2825S6AW9U
分子式:C21H29N分子量:295.46
产品CID: 1573356
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: YBJKOPHEJOMRMN-UHFFFAOYSA-N
1S/C21H29N/c1-17(2)22(18(3)4)16-15-21(19-11-7-5-8-12-19)20-13-9-6-10-14-20/h5-14,17-18,21H,15-16H2,1-4H3
计算化学: 氢键受体数1.0氢键供体数0可旋转键数7

物理性质

沸点391.7 °C at 760 mmHg
闪点170.8 °C
密度0.954g/cm3
PSA:3.24
LogP:5.3274
折射率1.534
外观形态固体-粉末
储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

MSDS等安全信息

警示词Warning
危险描述H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
防范说明P264Thoroughly clean after treatmentP280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective maskP305If it enters the eyesP351Rinse carefully with water for a few minutesP338Remove the contact lens(If any)And easy to operate,Continue flushingP337If eye irritation persistsP313Obtain medical advice/care
安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body

上下游产品

合成工艺路线路线简述

合成目标产物 Diisopromine 主要起始原料 1,1-Diphenylethylene And Carbon Monoxide And Diisopropylamine
(文献来源)合成步骤主要原料 1,1-Diphenylethylene 和 Carbon Monoxide 和 Diisopropylamine

📜3,3-二苯基丙醇置于lithium Carbonate,三乙胺体系中,用二氯甲烷,乙腈作为反应溶剂,化学反应 52.0H,反应生成地索普明
参考文献:Pd催化3,3-二苯基烯丙醇的选择性加氢:3,3-二芳基丙胺药物diisopromine和feniprane的高效合成
标题:Pd催化3,3-二苯基烯丙醇的选择性加氢:3,3-二芳基丙胺药物diisopromine和feniprane的高效合成
摘要:C的pd-催化的选择性氢化使用不同的催化体系[的pd / C,将pd(oac)在(3,3-Diphenylallyl)二异丙基胺或3,3-Diphenylallyl醇c双键进行评价2 /离子液体,分离的pd(0)纳米粒子].对于(3,3-二苯基烯丙基)二异丙胺,优选氢解而不是氢化,并且对于所需产物仅获得中等选择性.但是,使用分离的pd(0)纳米粒子在温和条件下氢化3,3-二苯基烯丙基醇可获得完全转化率和100%选择性.这一成功的策略使二异丙胺和芬尼普兰药物的有效合成成为可能,并为制备其他具有生物活性的化合物开辟了新的可能性.
DOI:10.1016/j.Catcom.2017.08.025

海关参考信息

2902600000-乙苯
2921199090-其他无环单胺
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-7993390-B2
优先权日:2002-02-08
标题:Implantable or insertable medical device resistant to microbial growth and biofilm formation
发明人：MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN
权利人:BOSTON SCIENT SCIMED INC
摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.