CAS: 54655-07-1; Lithium (Trimethylsilyl)Acetylide

📜二(三甲基甲硅烷基)乙炔 在 甲基锂体系中,用 四氢呋喃,乙醚作为反应溶剂,反应 2.0H,获得 Lithium Trimethylsilylacetylenide
参考文献:非对映选择性合成杂取代的有机金双金属试剂.在乙烯基金属新的炔丙基金属化反应中的应用
标题:非对映选择性合成杂取代的有机金双金属试剂.在乙烯基金属新的炔丙基金属化反应中的应用
摘要:各种γ-杂取代乙烯基金属的烯丙基锌和炔丙基锌非对映选择性地进行.这代表了一种新的合成方法,可在无环系统中构建两个或三个相邻的立体中心.
Doi:10.1016/0040-4020(96)00248-7

专利信息

专利号:US-5739358-A
优先权日:1996-10-03
标题:Synthesis of acetogenins
发明人：HOYE THOMAS R; YE ZHIXIONG
权利人:UNIV MINNESOTA
摘要:A method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enzyme.

专利号:US-6448412-B1
优先权日:1995-07-31
标题:Methods for the preparation and characterization of multi-substituted fullerenes
发明人：MURPHY RANDALL B; WILSON STEPHEN R; LU QUING
权利人:SPHERE BIOSYSTEMS INC
摘要:The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the C n fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3 He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.

专利号:WO-2016037566-A1
优先权日:2014-09-09
标 题:Use of antroqiononol for treating obesity, and process for preparation of antroquinonol
发明人：WENG CHING-FENG; CHEN CHIN-PIAO; SHIVAJI SULAKE ROHIDAS; Huang zi-ling
权利人:WENG CHING-FENG
摘要:Provided is the use of antroquinonol for manufacturing a composition or medicament for treating obesity. In addition, new processes for the total synthesis of antroquinonol and new compounds produced during the processes are disclosed.

专利号:WO-2024178474-A1
优先权日:2023-03-02
标题 :Flow chemistry process for preparing aza-bicyclic heteroaryl compounds
发明人：WILLIAMS JASON DOUGLAS; PRIESCHL MICHAEL
权利人:ACTINOGEN MEDICAL LTD
摘要:The present disclosure relates to a continuous flow process for synthesis of heterocyclic methanone compounds, and in particular 3'-substituted, 3-hydroxyl-(8-aza- bicyclo[3.2.1]oct-8-yl)-[5-(1h-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds, and aza-bicyclo intermediates thereof. In particular, the present disclosure also relates to a continuous flow process that can be utilised toward the synthesis of Xanamem.

专利号:WO-2022148752-A9
优先权日:2021-01-08
标 题 :Photochromic dyes and polymeric matrix for an efficient dimming film
发明人：KARIPIDOU ZOI; KNORR NIKOLAUS; HENNIG DIANA; ROSSELLI SILVIA; ONO HIDEKI; TAKANASHI HIDEHIKO; HERON MARK; EDGAR ROSS
权利人:SONY GROUP CORP; SONY EUROPE BV
摘要:The present disclosure relates to a photochromic molecule and uses of said molecule. The present disclosure further relates to a method of preparing a film comprising said molecule. The present disclosure also relates to a film prepared using said molecule and a device comprising said molecule. Furthermore, the present disclosure relates to a method for synthesis of said molecule. The photochromic molecules are represented by the following formulas: (1), (2), (3), (4), wherein Ar1, Ar2, Ar3, Ar4, Ar5, Ar6, Ar7, and Ar8 are, at each occurrence, independently selected from the group consisting of formula (I).

专利号:US-5502183-A
优先权日:1992-01-28
标 题 :Steroid intermediates and processes for their preparation
发明人：ANDREWS DAVID R; SUDHAKAR ANANTHA R
权利人:SCHERING CORP
摘要:PCT No. PCT/US93/00211 Sec. 371 Date Jul. 25, 1994 Sec. 102(e) Date Jul. 25, 1994 PCT Filed Jan. 26, 1993 PCT Pub. No. WO93/15103 PCT Pub. Date Aug. 5, 1993.Novel steroids having a 9 alpha -hydroxy or a 9 alpha -carbonate substituent can be prepared from 9 alpha -hydroxyandrostenedione and can be utilized in the synthesis of commercially valuable corticosteroids such as betamethasone. The 9 alpha -carbonates are prepared by reaction of the corresponding 9 alpha -hydroxy steroid with a sequence of excess base, trialkylsilyl chloride, alkyl haloformate and alkanol or by using excess base, alkyl haloformate and alkoxide. 9 alpha -Carbonate-17-keto compounds can be treated with lithium acetylide and a lithium salt to afford the corresponding 17 alpha -ethynyl-17 beta -hydroxy-9 alpha -carbonate. This compound is then esterified with a novel series of reagents to give the 17-ester which can be reduced the corresponding 17-allene. Oxidation of this allene to the bis-epoxide compound, followed by treatment with an alkali metal salt of a carboxylic acid under phase transfer conditions gives the 17 alpha -hydroxy 21-ester 9 alpha -carbonate. Elimination of the 9 alpha -carbonate group affords the a 17 alpha -hydroxy, 9(11)ene, which in a few subsequent steps can be converted to a variety of commercially important corticosteroids. Novel 9 alpha -carbonate compounds are prepared in the various reaction steps.