CAS: 5351-23-5; 4-Hydroxybenzhydrazide

该化合物是有机化合物,其特点是存在一个氢氮功能组和一个附属于苯并硫酸结构的氢氧化物组,该化合物一般是白色至非白晶状固体,在水和酒精等极地溶剂中溶解,表明其具有水和酒精等水和水合物组,表明其具有水益性质,该化合物在制药和有机合成中作为试剂的潜在用途,它可能表现出生物活动,包括抗微生物特性,使其对医药化学感兴趣,此外,4-Hydroxbenzoic酸氢氮化物可因其反应功能组而参与各种化学反应,例如凝结和结合,在处理和储存时,应参考安全数据,如任何化学物质,以确保遵循适当的实验室做法.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号99-76-3 尼泊金甲酯 | CAS号99-96-7 4-羟基苯甲酸 | CAS号120-47-8 尼泊金乙酯 | CAS号62500-75-8 4,4'-((6-(dieth... | CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号61370-95-4 4-[[4-(4-carbon... | CAS号62500-77-0 4,4'-((6-(diphe... | CAS号66996-57-4 N-[1-[4-(4-amin... | CAS号95167-41-2 DY131 | CAS号99-96-7 4-羟基苯甲酸 | CAS号2908-80-7 3-(4-hydroxyphe... | CAS号25877-46-7 4-(5-甲基-1,3,4-噁... | CAS号877874-79-8 4-(5-(3-(三氟甲基)苯... | CAS号965-52-6 硝呋酚酰肼 | CAS号6554-98-9 反式-4-羟基芪 | CAS号5378-27-8 4-(1,3,4-噁二唑-2-基)苯酚 | CAS号43100-26-1 N,N'-bis(p-hydr... | CAS号70-55-3 对甲苯磺酰胺

合成工艺路线路线简述

  • 合成目标产物 4-Hydroxybenzhydrazide 主要起始原料 Methylparaben
  • (文献来源)合成步骤主要原料 Methylparaben
对羟基苯甲酸甲酯置于一水合肼体系中,用 乙醇 作为反应溶剂,以80%的收率获得产物4-羟基苯甲酰肼
参考文献:新型荧光n-酰基hydr和semicarbazone-7-Oh-香豆素染料的微波辅助合成和光物理研究†
标题:新型荧光n-酰基hydr和semicarbazone-7-Oh-香豆素染料的微波辅助合成和光物理研究†
摘要:新颖的微波辅助合成ñ-Acylhydrazone和semicacarbazone-7-Hidroxy香豆素衍生物,由3-乙酰基-7-羟基-2-开始ħ-色烯-2-酮,进行说明.此优化方案可提高收率,并使反应时间从约24小时减少到约1小时.这些化合物的水溶液显示出明亮的蓝色至青色发射,最大量子产率为0.244.连接基团的立体电子效应通过偏爱顺式或反酰胺构象异构体导致光谱特性的调节.所合成的化合物显示出ph依赖的发光和在低极性介质(甲醇)强烈batochromic移位至65纳米,由于更好的稳定化的顺式-促进这种红移的合格者.这些特性可用于设计用于ph以及极性微环境的新型发光探针.
DOI:10.1039/c6Nj01532H

海关参考信息

专利信息


专利号:US-9085550-B2
优先权日:2005-01-21
标题 :Ligands for estrogen related receptors and methods for synthesis of said ligands
发明人:FORMAN BARRY; YU DONNA
权利人:FORMAN BARRY; YU DONNA; HOPE CITY
摘要:Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described.

专利号:US-2017204442-A1
优先权日:2014-05-29
标题 :Enzymatic synthesis of soluble glucan fiber
发明人:DICOSIMO ROBERT; CHENG QIONG; ELIOT ANDREW C; OUWEHAND ARTHUR; PAYNE MARK S; YOU ZHENG
权利人:DU PONT
摘要:An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.

专利号:US-10907185-B2
优先权日:2014-05-29
标 题 :Enzymatic synthesis of soluble glucan fiber
发明人:CHENG QIONG; DICOSIMO ROBERT; OUWEHAND ARTHUR; YOU ZHENG; LAI JIAN PING; YU ZHEYONG; ZHANG ZHENGHONG
权利人:DUPONT IND BIOSCIENCES USA LLC
摘要:An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.

专利号:US-4713383-A
优先权日:1984-10-01
标 题:Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
发明人:FRANCIS JOHN E; GELOTTE KARL O
权利人:CIBA GEIGY CORP
摘要:[1,2,4]triazolo[1,5-c]quinazoline compounds of the formula wherein R1 is optionally substituted phenyl, pyridyl, furyl thienyl, dihydro or tetrahydro furanyl or thienyl, pyranyl, or 0-ribofuranosyl; R2 is hydrogen or lower alkyl; X is oxygen or NR3, R3 is as defined in the claims, and ring A is unsubstituted or substituted as set forth in the claims. The compounds wherein X is N-R3 are especially useful as adenosine antagonists and for the treatment of asthma. The compounds wherein X is oxygen are useful as benzodiazepine antagonists and as intermediates in the synthesis of the compounds wherein X is N-R3.

专利号:US-2017198323-A1
优先权日:2014-05-29
标题:Enzymatic synthesis of soluble glucan fiber
发明人:CHENG QIONG; DICOSIMO ROBERT; OUWEHAND ARTHUR; YOU ZHENG; PAYNE MARK S; PRASAD JAHNAVI CHANDRA
权利人:DU PONT
摘要:An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.

专利号:US-12110347-B2
优先权日:2014-05-29
标 题:Enzymatic synthesis of soluble glucan fiber
发明人:CHENG QIONG; DICOSIMO ROBERT; OUWEHAND ARTHUR; YOU ZHENG; PAYNE MARK S; LAI JIAN PING; RUEBLING-JASS KRISTIN; ROTHMAN STEVEN CARY
权利人:NUTRITION & BIOSCIENCES USA 4 INC
摘要:An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.
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主要参考文献

[参考文献]: A Jerlich, Et Al. Comparison Of Hocl Traps With Myeloperoxidase Inhibitors In Prevention Of Low Density Lipoprotein Oxidation. Biochim Biophys Acta. 2000 Aug 31;1481(1):109-18.
[参考文献]: Deepa C Khandekar, Et Al. Kinetics Of Sucrose Conversion To Fructo-Oligosaccharides Using Enzyme (Invertase) Under Free Condition. Bioprocess Biosyst Eng. 2014 Dec;37(12):2529-37.
[参考文献]: M Lever, Et Al. Optimal Conditions For 4-Hydroxybenzoyl- And 2-Furoylhydrazine As Reagents For The Determination Of Carbohydrates, Including Ketosamines. Anal Biochem. 1984 May 15;139(1):205-11.
[参考文献]: Phedias Diamandis, Et Al. Chemical Genetics Reveals A Complex Functional Ground State Of Neural Stem Cells. Nat Chem Biol. 2007 May;3(5):268-73.
[参考文献]: Rahul Kashyap, Et Al. Kinetics And Model Development For Enzymatic Synthesis Of Fructo-Oligosaccharides Using Fructosyltransferase. Bioprocess Biosyst Eng. 2015 Dec;38(12):2417-26.

合成参考文献


参考文献:10.1007/s10529-010-0223-y
摘要:Wu H, Pei J, Jiang Y, Song X, Shao W. pHsh vectors, a novel expression system of Escherichia coli for the large-scale production of recombinant enzymes. Biotechnol Lett. 2010 Jun;32(6):795–801. doi: 10.1007/s10529-010-0223-y.
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