CAS: 4075-59-6; 2-Oxo-2-(Thiophen-2-yl)Acetic Acid

该化合物是一种有机化合物,其特点是存在硫苯环和催氧酸功能组,该化合物一般是白到浅黄色晶体固体,其酸性因碳盒酸组而闻名,可参与各种化学反应,包括酯化和恐吓.硫苯基酸有助于其芳香特性,并可影响其有机溶剂的再活性和溶性. 2-硫苯基氧酸经常用于有机合成,特别是用于制药和农用化学品开发,因为它能够成为更复杂的分子的建筑块.此外,其独特结构允许在材料科学中和作为捆绑和化学协调中的潜在应用.与许多有机酸一样,必须谨慎处理这一化合物,遵守适当的安全议定书,以减少其使用带来的任何风险.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

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合成工艺路线路线简述

    📜2-(4-Dimethylamino-Phenylimino)-3-Oxo-3-[2]Thienyl-Propionitrile置于盐酸体系中,化学反应生成 2-噻吩乙醛酸
    参考文献:Kroehnke,Chemische Berichte,1947,Vol. 80,P. 298,310
    标题:Kroehnke,Chemische Berichte,1947,Vol. 80,P. 298,310

    海关参考信息

    专利信息


    专利号:US-2021323987-A1
    优先权日:2018-08-20
    标题:Methods for the Synthesis of Heteroatom Containing Polycyclic Aromatic Hydrocarbons
    发明人:GARG NEIL K; DARZI EVAN R; BARBER JOYANN S; SUSICK ROBERT; CHARI JASON; SPENCE KATIE
    权利人:UNIV CALIFORNIA
    摘要:Methods for the synthesis of polycyclic aromatic hydrocarbons and synthesis platforms for performing such syntheses are provided. Methods and platforms are provided that allow for the synthesis of aza-polycyclic aromatic hydrocarbons by an expedient ring assembly. Methods and platforms allow for a modular approach to synthesis that provide multiple new C—C bonds in sequential pericyclic reactions, thus giving access to compounds with multiple axes of substitution.

    专利号:US-7109377-B2
    优先权日:1996-10-16
    标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
    发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
    权利人:HARVARD COLLEGE
    摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

    专利号:US-2003082830-A1
    优先权日:1996-10-16
    标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

    专利号:US-4221915-A
    优先权日:1977-03-11
    标题:Process for preparing thiophene derivatives and thiophene derivatives obtained thereby
    发明人:KONDO KIYOSHI; TSUNEMOTO DAIEI; FUJISAWA TAMOTSU
    权利人:SAGAMI CHEM RES
    摘要:Process for the preparation of a series of thiophene derivatives, from which 2-thiopheneacetic acid derivatives can easily be prepared, in high yields and selectivity by using substituted or unsubstituted thiophenes as the starting materials by easy operations. 2-Thiopheneacetic acid derivatives are very useful compounds as the chemical modifier of penicillin and cephalosporin. Novel compounds, i.e. α-arylthio-2-thiopheneacetic acids are also disclosed. These compounds are useful as the intermediates of the synthesis of 2-thiopheneacetic acids.

    专利号:WO-0006525-A9
    优先权日:1998-07-25
    标题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

    专利号:WO-0006525-A2
    优先权日:1998-07-25
    标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Bin Yu, Et Al. [参考文献]: Guang Pu Xue Yu Guang Pu Fen Xi. 2004 Dec;24(12):1571-4.

    合成参考文献


    摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 105.
    摘要:Haufe, G., Science of Synthesis Knowledge Updates, (2019) 3, 283.
    摘要:Nakao, Y., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 423.
    摘要:Zhou, Q.-Q.; Wei, Y.; Lu, L.-Q.; Xiao, W.-J., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 195.
    摘要:Zhou, Q.-Q.; Wei, Y.; Lu, L.-Q.; Xiao, W.-J., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 178.
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