CAS: 3964-04-3; 4-Bromoquinoline

相似化合物

4964-71-0 700871-88-1 34522-69-5

上下游产品

CAS号611-36-9 4-羟基喹啉 | CAS号529-37-3 喹啉-4(1H)-酮 | CAS号56-57-5 4-硝基喹啉-N-氧化物 | CAS号22614-98-8 4-溴喹啉1-氧化物 | CAS号578-68-7 4-氨基喹啉 | CAS号7789-60-8 三溴化磷 | CAS号141-78-6 乙酸乙酯 | CAS号7664-93-9 硫酸 | CAS号10035-10-6 氢溴酸 | CAS号607-31-8 4-甲氧基喹啉 | CAS号394-70-7 4-氟喹啉 | CAS号371764-64-6 4-喹啉硼酸 | CAS号5632-13-3 4-氨基甲基喹啉盐酸盐 | CAS号486-74-8 4-喹啉羧酸 | CAS号611-35-8 4-氯喹啉 | CAS号578-68-7 4-氨基喹啉 | CAS号529-37-3 喹啉-4(1H)-酮 | CAS号605-03-8 4-苯基喹啉 | CAS号10447-29-7 4-喹啉甲酸乙酯

喹啉置于n-溴代丁二酰亚胺(Nbs)体系中,用 乙醇 作为反应溶剂,化学反应 3.5H,以86.9%的收率获得产物4-溴喹啉
参考文献:一种咪喹莫特中间体的合成方法
标题:一种咪喹莫特中间体的合成方法
摘要:本发明公开了一种咪喹莫特中间体的合成方法,包括以下步骤:步骤一:在催化剂条件下,喹啉与nbs在溶剂中加热反应,得到化合物2;步骤二:在溶剂中,将化合物2与异丁胺混合,加入催化剂加热反应,得到化合物3;步骤三:化合物3与nbs在溶剂中加热反应,得到化合物4;步骤四:第一阶段,化合物4与甲酰胺在催化剂的作用下,加热反应;第二阶段,再以盐酸处理得到化合物1.与现有技术相比,本发明方法起始原料价格便宜,各步反应操作简单收率较高,三废少,生产效率高.

专利信息

专利号:US-6500955-B1
优先权日:2001-02-02
标 题:One pot synthesis of [2,8-Bis (trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone, a mefloquine intermediate
发明人：CHAWLA HARMANDER PAL SINGH; JOHAR PERMINDER SINGH; MITTAL ALKA; MEENA RAM AVTAR; NEGI VILLENDRA SINGH
权利人:NAT INST OF PHARMACEUTICAL EDU
摘要:The present invention provides a simple single step process for the preparation of [2,8-bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone, comprising the step of condensing a halo-quinoline with an alpha-picolyl derivatives in the presence of a solvent, a base and a phase transfer catalyst at −10° C. to +90° C.

专利号:WO-2012107532-A1
优先权日:2011-02-11
标 题 :4-aminoalcoholquinoline derivatives, enantioselective synthesis methods and the use thereof
发明人：JONET ALEXIA; DASSONVILLE-KLIMPT ALEXANDRA; MULLIE CATHERINE; TAUDON NICOLAS; SONNET PASCAL
权利人:UNIV PICARDIE; JONET ALEXIA; DASSONVILLE-KLIMPT ALEXANDRA; MULLIE CATHERINE; TAUDON NICOLAS; SONNET PASCAL
摘要:The present invention is intended to provide new antimalarial compounds with a strong antimalarial activity as well as antibacterial activity with few neurological side effects and a new enantioselective pathway to mefloquine amino-analogs allowing the access of such compounds. The present invention relates to new 4 -aminoalcohol quinoline derivatives of formula (I), as well as the synthesis methods and the uses of such derivatives. In which Y is one selected from formulae (II) to (III). In which Z is selected from formulae (IV) to (VI), and wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and n are as defined in the claims.

专利号:US-3839346-A
优先权日:1972-12-18
标 题:N-substituted pyridone and general method for preparing pyridones
发明人：GADEKAR S
权利人:AFFILIATED MED RES
摘要:1. A PROCESS FOR THE SYNTHESIS OF PYRIDONES OF THE FORMULA 1-A,2-(O=),3-R3,4-R4,5-R5,6-R6-1,2-DIHYDROPYRIDINE WHEREIN A IS AN AROMATIC RADICAL SELECTED FROM THE GROUP CONSISTING OF PHENYL, TOLYL, CHLOROPHENYL, TRIFLUOROMETHYLPHENYL, NAPHTHYL, PYRIDYL, FURYL, THIENYL, THIAZOLYL, PYRIMIDYL, QUINOLYL, IMIDAZOLYL; UP TO TWO OF THE TERMS R3, R4, R5 AND R6 ARE INDIVIDUALLY EACH HYDROGEN OR ALKYL UP TO 6 CARBON ATOMS, ARYL OR SUBSTITUTED ARYL RADICALS WHICH CONSISTS ESSENTIALLY OF THE STEPS OF REACTING A PYRIDONE OF THE FORMULA 2-(O=),3-R3,4-R4,5-R5,6-R6-1,2-DIHYDROPYRIDINE, OR ITS TAUTOMER, 2-(HO-),3-R3,4-R4,5-R5,6-R6-PYRIDINE IN WHICH R3, R4, R5 AND R6 ARE SET FORTH ABOVE, WITH A HALOGENATED COMPOUND OF THE FORMULA AX, WHEREIN X IS EITHER CHLORINE, BROMINE OR IODINE, AT TEMPERATURES RANGING BETWEEN THE MELTING POINT AND BOILING POINT OF SAID HALOGENATED COMPOUND, IN THE PRESENCE OF AN ALKALI METAL CARBONATE AND FINELY DIVIDED METALLIC COPPER.

专利号:US-8633182-B2
优先权日:2012-05-30
标题:Indanyloxyphenylcyclopropanecarboxylic acids
发明人：HAMPRECHT DIETER; FRATTINI SARA; LINGARD IAIN; PETERS STEFAN
权利人:HAMPRECHT DIETER; FRATTINI SARA; LINGARD IAIN; PETERS STEFAN; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of general formula I, n nwherein the groups R 1 , R 2 , R 3 , m and n are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.

专利号:CN-1370777-A
优先权日:2001-02-02
标题:Improved single-reactor synthesis of [2,8-di(trifluoromethyl)-4-quinolyl]-2-pyridyl methyl ketone and methylfluoro quine

专利号:US-2002188129-A1
优先权日:2001-02-02
标题:One pot synthesis of [2, 8-bis (trifluoromethyl)-4- quinolinyl]2-pyridinylmethanone, a mefloquine intermediate