CAS: 3320-83-0; 2-Chlorophenylisocyanate

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CAS号32315-10-9 三光气 | CAS号95-51-2 2-氯苯胺 | CAS号17512-69-5 2-chloro-N-hydr... | CAS号75-44-5 光气 | CAS号201230-82-2 carbon monoxide | CAS号88-73-3 邻氯硝基苯 | CAS号609-66-5 2-氯苄胺 | CAS号137-04-2 2-氯苯胺盐酸盐 | CAS号35580-76-8 N-(2-氯苯基)肼甲酰胺 | CAS号20668-13-7 (2-氯苯基)氨基甲酸甲酯 | CAS号2740-81-0 2-氯苯基异氰酸酯 | CAS号6388-47-2 2-氨基-3-氯苯甲酸 | CAS号13208-21-4 Urea,N-(2-chlor... | CAS号13909-18-7 1-(2-chloroethy... | CAS号13143-19-6 N-(2-Chlorophen... | CAS号13208-22-5 N-(3,4-Dichloro... | CAS号13208-68-9 Urea,N-(2-chlor... | CAS号1567-00-6 Benzoic acid,2-...

2-氯苯甲酸置于叠氮磷酸二苯酯,三乙胺体系中,用 苯 用作溶剂,化学反应 2.75H,反应生成1,2,4-三氯萘
参考文献:基于四氢异喹啉的二芳基尿素衍生物的设计,合成和生物学评估,用于抑制vegfr-2信号传导.
标题:基于四氢异喹啉的二芳基尿素衍生物的设计,合成和生物学评估,用于抑制vegfr-2信号传导.
摘要:结合二芳基脲部分的新型基于四氢异喹啉的化合物的结构系列被设计,合成,并通过生物学方法评估为vefgr-2信号的抑制剂.结果,化合物9K和9S对吉非替尼对被测试的三种细胞系,包括a549,Mcf-7和pc-3,表现出与吉非替尼相当或更高的细胞毒性.重要的是,它们两个都下调了vegfr-2的表达,并以0.5或1.0μmol/ L的浓度抑制了vegfr-2的磷酸化.此外,它们以4.0μmol/ L的浓度抑制人脐静脉内皮细胞管的形成.考虑到它们下调vegfr-2表达和抑制vegfr-2磷酸化的能力,9K和9S可以作为血管生成的抑制剂,以供进一步研究.
Doi:10.1097/cad.0000000000000718

专利信息

专利号:US-4267070-A
优先权日:1979-10-30
标题:Catalyst for the synthesis of aromatic monoisocyanates
发明人：NEFEDOV BORIS K; MANOV-JUVENSKY VLADIMIR I; DERGUNOV JURY I; RYSIKHIN ANATOLY I; CHIMISHKIAN ALEXANDR L
权利人:NEFEDOV BORIS K; MANOV JUVENSKY VLADIMIR I; DERGUNOV JURY I; RYSIKHIN ANATOLY I; CHIMISHKIAN ALEXANDR L
摘要:A catalyst for the synthesis of aromatic monoisocyanates comprising 1.64 to 16.6% by weight of palladium chloride, 0.16 to 47.6% by weight of an oxide of a metal of Group VB of the periodic system, 1.5 to 81.8% by weight of an oxide of a metal of Group VI B of the periodic system, 1.64 to 89.8% by weight of pyridine or an alkylsubstituted pyridine. n The use of the catalyst according to the invention in the synthesis of aromatic monoisocyanates makes it possible to obtain a high degree of conversion of the starting compound of up to 100%, a high yield of the desired product of up to 97%, and increased productivity of the catalyst of up to 40 g of the desired product per g of PdCl 2 per hour.

专利号:US-2023348657-A1
优先权日:2020-07-23
标题 :Synthesis of linear polyoxazolidinones using uretdiones as diisocyanate component
发明人：QUELL AGGELIKI; THOMAS HANS-JOSEF; ELING BEREND
权利人:BASF SE
摘要:A process for preparing a thermoplastic polymer involves reacting at least components (a) to (b), in the presence of a catalyst composition (c). Component (a) is an isocyanate composition containing at least one uretdione diisocyanate (a-i), and component (b) is an epoxide composition containing at least one diepoxide (b-i). The catalyst composition (c) contains at least one ionic liquid (c-i), preferably selected from 1-ethyl-3-methyl imidazolium bromide, 1-benzyl-3-methyl imidazolium chloride. 1-butyl-1-methylpiperidinium chloride, 1-ethyl-2,3-dimethylimidazolium bromide, 1-(2-hydroxyethyl)-3-methyl imidazolium chloride, butyl-1-methylpiperidinium acetate, or mixtures of two or more thereof. A thermoplastic polymer obtained or obtainable from the process is useful for the preparation of a fibre or a molded article or as a modifier for another thermoplastic material.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-10385167-B2
优先权日:2015-02-13
标题:Process for the synthesis of polyoxazolidinone compounds with high stability
发明人：MÃœLLER THOMAS ERNST; Gürtler Christoph; BASU SUSMIT; RANGHEARD CLAUDINE; RIVILLO DAVID; LEITNER WALTER; Köhler Burkhard
权利人:COVESTRO DEUTSCHLAND AG
摘要:The present invention relates to polyoxazolidinone compounds, a method for the production of polyoxazolidinone compounds, comprising the step of reacting a biscarbamate compound with a bisepoxide compound in the presence of a mono-carbamate, a mono-isocyanate and/or a mono-epoxide compound as chain regulator and a suitable base having a pK b value of ≤9 as catalyst. The invention further relates to the use of polyoxazolidinone compounds with high thermal stability.

专利号:US-11326018-B2
优先权日:2016-08-19
标 题:Process for the synthesis of polyoxazolidinone compounds
发明人：WEBER ANNA; RANGHEARD CLAUDINE; KESSLER MICHAEL; LEITNER WALTER; Gürtler Christoph; KOOPMANS CARSTEN; MÃœLLER THOMAS ERNST
权利人:COVESTRO DEUTSCHLAND AG
摘要:A method for the production of polyoxazolidinone compounds, comprising the step of reacting an isocyanate compound (A) with an epoxide compound (B) in the presence of a catalyst (C), wherein the isocyanate compound (A) comprises a isocyanate compound (A 1 ) wherein the a isocyanate compound (A1) comprising at least two isocyanate groups (I 1 ≥2), preferred two isocyanate groups (I 1 =2), wherein the epoxide compound (B) comprises a epoxide compound (B 1 ) and an epoxide compound (B 2 ), wherein the epoxide compound (B 2 ) is different from the epoxide compound (B 1 ) wherein the epoxide compound (B 1 ) comprising at least two terminal epoxide groups (F1≥2), preferred two terminal epoxide groups (F 1 =2), linked together by a linking group (L1) and the epoxide compound (B 2 ) comprising at least two terminal epoxide groups (F 2 ≥2)), preferred two terminal epoxide groups (F 2 =2), linked together by a linking group (L 2 ), wherein the linking group (L 2 ) comprises acyclic and covalent bonds to each other free of conjugated multiple bonds within the main chain, wherein the epoxide compound (B 2 ) is present in the epoxide compounds B 1 and B 2 , in an amount of ≥0.01 mol-% to <10 mol-%, preferred 1-9 mol-% more preferred 3-8 mol-% based on the molar ratio the terminal epoxide groups in the epoxide compound (B 1 ) and of the sum of the terminal epoxide groups in the epoxide compound (B 1 ) and terminal epoxide groups in the epoxide compound (B 2 ).

专利号:US-2022281888-A1
优先权日:2019-09-25
标题:Bicyclic carboxylates as modulators of transporters and uses thereof
发明人：SANDANAYAKA VINCENT; GORECZNY GREGORY
权利人:NIROGY THERAPEUTICS INC
摘要:The present invention generally relates to the field of transporter modulators, e.g., monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.