乙酰乙酸甲酯置于氯体系中,用 四氯化碳 作为反应溶剂,化学反应生成 4-氯乙酰乙酸甲酯 参考文献:Compositions And Methods For The Treatment Of Periodontitis And Rheumatoid Arthritis 标题:Compositions And Methods For The Treatment Of Periodontitis And Rheumatoid Arthritis 摘要:该发明涉及公式i的化合物或其药用可接受的盐,以及其多晶型,溶剂合物,对映体,立体异构体和水合物.包括公式i化合物的有效量的药物组合物,以及用于牙周炎和类风湿关节炎治疗的方法可以制成口服,颊内,直肠,局部,经皮,经粘膜,静脉,肠道,糖浆或注射剂的制剂.
专利号:WO-2025128106-A1 优先权日:2023-12-14 标 题 :Pharmaceutical intermediates and methods for preparing the same in the synthesis of muscimol and congeners and derivatives thereof 发明人:BOULANGER WILLIAM; TONG ZONGBO 权利人:BOULANGER WILLIAM ALLEN; TONG ZONGBO 摘要:Pharmaceutical intermediates and methods for efficiently preparing muscimol mono-BOC and derivatives thereof in the synthesis of muscimol and congeners and derivatives thereof.
专利号:US-11998531-B1 优先权日:2023-12-14 标 题:Pharmaceutical intermediates and methods for preparing the same in the synthesis of muscimol and congeners and derivatives thereof 发明人:BOULANGER WILLIAM ALLEN; TONG ZONGBO 权利人:BOULANGER WILLIAM ALLEN; TONG ZONGBO 摘要:Pharmaceutical intermediates and methods for efficiently preparing muscimol mono-BOC and derivatives thereof in the synthesis of muscimol and congeners and derivatives thereof.
专利号:WO-2015019310-A1 优先权日:2013-08-07 标 题 :Process for the preparation of dolute-gravir and intermediates thereof 发明人:DANDALA RAMESH; VELLANKI SIVA RAM PRASAD; NADELLA MADHU MURTHY; BALUSU PHANI KUMAR 权利人:MYLAN LAB LTD 摘要:The present disclosure relates to processes for the preparation of dolutegravir or of its pharmaceutically acceptable salts. The present disclosure also provides intermediates useful in the synthesis of dolutegravir.
专利号:WO-2004058711-A1 优先权日:2002-12-30 标 题 :Isolation of dihydropyridine derivative and preparation salts thereof 发明人:ASLAN TUNCER; ADIYAMAN MUSTAFA; YURDAKUL AYCIL; SAHPAZ FILIZ; OZARSLAN EVREN A; GUNER DIDEM; RIDVANOGLU NURTEN 权利人:EOS ECZACIBASI OZGUN KIMYASAL; ASLAN TUNCER; ADIYAMAN MUSTAFA; YURDAKUL AYCIL; SAHPAZ FILIZ; OZARSLAN EVREN A; GUNER DIDEM; RIDVANOGLU NURTEN 摘要:The title compound is isolated in pure form by using a crystallization process and converted to its pharmaceutically acceptable salts. The crystallization process affects stability and purity of the amlodipine salts. All known impurities and one unknown impurity, which forms during the synthesis of the amlodipine salts, were isolated, characterized, and synthesized. A new method allowing the quantitative HPLC analysis of all related impurities of amlodipine salts in a single chromatogram was developed.
专利号:WO-2010108584-A1 优先权日:2009-03-26 标题:Synthesis of n-substituted furan-2(5h)-ones 发明人:IGNATYEV NIKOLAI MYKOLA; ZLOTIN SERGEI G; SIMIRSKAYA NINA I 权利人:MERCK PATENT GMBH; IGNATYEV NIKOLAI MYKOLA; ZLOTIN SERGEI G; SIMIRSKAYA NINA I 摘要:The present invention relates to a process for preparing N-substituted furan-2(5H)-ones where the reaction medium comprises at least one Ionic Liquid, to the use of Ionic Liquids for preparing furan-2(5H)-ones, and to compounds preparable by the aforementioned process.
专利号:WO-2014203045-A1 优先权日:2013-06-20 标 题:A novel, green and cost effective process for synthesis of tert-butyl (3r,5s)-6-oxo-3,5-dihydroxy-3,5-o-isopropylidene-hexanoate 发明人:ROY BHAIRABNATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; TRIVEDI ANURAG; PISE VIJAY SADASHIV; RUPANWAR MANOJ 权利人:LUPIN LTD 摘要:The present invention provides a process of preparation of an intermediate useful for the preparation of statins more particularly the present invention relates to an eco-friendly and cost effective process for the preparation of tert -butyl (3R,5S)-6-oxo-3,5-dihydroxy- 3,5-O-isopropylidene-hexanoate [I].