CAS: 253-52-1; Phthalazine

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CAS号100-52-7 苯甲醛 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号484-23-1 双肼屈嗪 | CAS号21415-94-1 2 (1H)-Phthalaz... | CAS号643-79-8 邻苯二甲醛 | CAS号65997-87-7 Benzaldehyde azine | CAS号91-15-6 邻苯二甲腈 | CAS号576-22-7 2-溴间二甲苯 | CAS号38710-51-9 2-methyl-phthal... | CAS号105937-05-1 phenyl 1-cyano-... | CAS号87-41-2 苯酞 | CAS号7468-67-9 2-氰基苯甲醛 | CAS号89898-86-2 5-硝基酞嗪 | CAS号91-15-6 邻苯二甲腈 | CAS号119-39-1 2,3-二氮杂萘酮 | CAS号643-79-8 邻苯二甲醛 | CAS号17300-02-6 邻亚二甲苯二胺 | CAS号18636-89-0 PHTHALAZINE-2-OXIDE | CAS号91-57-6 2-甲基萘

邻苯二甲醇置于hydrazine Hydrate,C17H15Cl2N5Nio,Potassium Tert-Butylate体系中,用 甲苯 用作溶剂,化学反应 24.0H,以52%的收率获得2,3-二氮杂萘
参考文献:空气中由芳醇和肼形成的配体氧化还原控制的串联式叠氮化合物的合成:邻苯二嗪的一锅法合成
标题:空气中由芳醇和肼形成的配体氧化还原控制的串联式叠氮化合物的合成:邻苯二嗪的一锅法合成
摘要:报道了通过使用2,6-双(苯基偶氮)吡啶的ni(II)络合物作为催化剂,从各种醇和水合肼制得的嗪的受控串联合成路线.与以前的报告形成鲜明对比的是,该反应是使用富含地球的金属催化剂,较温和的反应条件和有氧条件进行的,尽管这是理想的,但在文献中却是空前的.该催化反应具有广阔的底物范围,包括通过分子内偶联由1,2-苯二甲醇和水合肼一步合成邻苯二甲酸.机理研究表明,配位配体氧化还原通过使用可逆偶氮(n═n)/肼(nh-Nh)氧化还原对控制反应,其中金属中心主要用作模板.
Doi:10.1021/acs.Joc.8B00661

专利信息

专利号:US-7160517-B2
优先权日:2000-08-18
标题 :Apparatus and methods for the automated synthesis of oligosaccharides
发明人：SEEBERGER PETER H; PLANTE OBADIAH J
权利人:MASSACHUSETTS INST OF TECHNOLG
摘要:One aspect of the present invention relates to an apparatus for the efficient synthesis of oligosaccharides on a solid support, e.g., formed by subunit addition to terminal subunits immobilized on solid-phase particles. In certain embodiments, the apparatus of the present invention is used in combinatorial methods, e.g., as described herein, of synthesizing oligosaccharides.

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-7230101-B1
优先权日:2002-08-28
标 题:Synthesis of methotrexate-containing heterodimeric molecules
发明人：MURTHI KRISHNA K; SMITH CHASE C
权利人:GPC BIOTECH INC
摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

专利号:US-9126995-B2
优先权日:2011-11-08
标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
发明人：TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU
权利人:NISSAN CHEMICAL IND LTD
摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-2012302756-A1
优先权日:2010-02-19
标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines
发明人：LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
权利人:LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
摘要:The present invention provides a highly efficient, versatile one-step process for asymmetric synthesis of either diastereomer of 2-substituted pyrrolidines from a single starting material with excellent yields and high diastereoselectivety. Also provided is a method for the asymmetric synthesis of both diastereomers of 2-substituted piperidines with good yields and excellent diastereoselectivety. Diasteroselectivity is controlled effectively by choice of reducing agent.