CAS: 1983-81-9; 4,7-Dihydroxy-2H-Chromen-2-One

该化合物是苯并1,4,4,4-二丙酮衍生物,在有机合成中具有重要用途.该化合物展示了强效抗氧化剂和抗氟酸酯特性,使其成为制药和农用化学品开发的宝贵中间体.其独特的结构允许多种化学转化,提高了其在各种研究努力中的实用性.

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4-hydroxy-7-methoxycoumarine 2',4'-dihydroxy-4-acetophenone carbon monoxide 4-amino-7-hydroxy-2H-chromen-2-one H-chromen-3-yl)-(4-hydroxy-2-oxo-2H-chromen-3-yl)-acetic acid ethyl ester(4,7-dihydroxy-2-oxo-2H-chromen-3-yl)-(4-hydroxy-2-oxo-2H-chromen-3-yl)-acetic acid ethyl ester 7-hydroxy-4-(4-methoxy-benzoyloxy)-coumarin H-chromen-3-yl)-buta-1,3-dienyl]-3-methyl-4-phenyl-thiazolium betaine2-[4-(4,7-dihydroxy-2-oxo-2H-chromen-3-yl)-buta-1,3-dienyl]-3-methyl-4-phenyl-thiazolium betaine H-chromen-3-yl)-vinyl]-3-methyl-4-phenyl-thiazolium betaine2-[2-(4,7-dihydroxy-2-oxo-2H-chromen-3-yl)-vinyl]-3-methyl-4-phenyl-thiazolium betaine

合成工艺路线路线简述

    📜4-Amino-7-Hydroxy-2H-Chromen-2-One置于硫酸体系中,化学反应 4.0H,以68%的收率获得4,7-二羟基香豆素
    参考文献:抗艾滋病剂.37.(3'r,4'r)-(+)-顺式-甲壳酮衍生物作为新型有效的抗hiv剂的合成和构效关系.
    标题:抗艾滋病剂.37.(3'r,4'r)-(+)-顺式-甲壳酮衍生物作为新型有效的抗hiv剂的合成和构效关系.
    摘要:为了探索作为新型抗hiv药物的(+)-顺式-Khellactone衍生物的结构要求,使用24个单取代的3',4'-Di-O-(S)-樟脑酰基-(+)-顺式-Khellactone(dck)衍生物不对称合成.这些化合物包括4个异构的单甲氧基类似物(3-6),4个异构的单甲基类似物(7-10),4个4-烷基/芳基取代的类似物(11-14)和12个4-甲基-(+)-顺式具有3',4'取代基的khellactone衍生物(15-26).这些(+)-顺式-Khellactone衍生物被筛选针对急性感染的h9淋巴细胞中的hiv-1复制.结果表明,(3'R,4'R)-(+)-顺式-Khellactone骨架,3'-和4'-位置的两个(S)-(-)-樟脑酰基和甲基除6-位以外,香豆素环上的α是抗hiv活性的最佳结构部分.3-甲基-(7),4-甲基-(8)和5-甲基-(9)3',4'-二-O-(S)-樟脑酰基-(3'R,4'R)-
    Doi:10.1021/jm9900624

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    专利信息


    专利号:US-5510375-A
    优先权日:1993-11-19
    标 题 :Coumarin derivatives as protease inhibitors and antiviral agents
    发明人：DOMAGALA JOHN M; HAGEN SUSAN E; LUNNEY ELIZABETH; TAIT BRADLEY D
    权利人:WARNER LAMBERT CO
    摘要:The present invention relates to novel coumarin derivatives and related compounds which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The coumarin derivatives are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized coumarins and of related structures.

    专利号:US-2884427-A
    优先权日:1958-01-22
    标题 :Synthesis of coumestrol and its esters
    发明人：EMERSON OLIVER H; BICKOFF EMANUEL M
    权利人:EMERSON OLIVER H; BICKOFF EMANUEL M

    专利号:CN-107382944-A
    优先权日:2017-03-27
    标题 :A class of coumarin gossypol derivatives with anti-tumor activity and synthesis method thereof

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    合成参考文献


    摘要:Herter, S.; Turner, N. J., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 3, 96.
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