参考标题:Synthesis Of Alkyl Isothiazolidine-1,1-Dioxide 3-Carboxylates Via The Intramolecular Carbo-Michael Reaction Strategy 作者:Vitalii V. Izhyk,Anton O. Poliudov,Alexey V. Dobrydnev,Taras V. Omelian,Maria V. Popova,Yulian M. Volovenko |发布日期:2022.10 摘要:Cost-Effective Synthesis Of Alkyl Isothiazolidine-1,1-Dioxide 3-Carboxylates Starting From Commercially Available α-Amino Acid Ester Hydrochlorides. These Compounds Were Designed As Sulfonamide-Containing Bioisosteres Of Known Pharmacological Template - Pyroglutamic Acid (Pglu). Specifically, α-Amino Acid Ester Hydrochlorides Were Sulfonylated With (2-Chloroethyl)Sulfonyl Chloride Providing In One-Pot Manner