CAS: 19481-82-4; 2-Bromopropanenitrile

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32644-15-8 10009-70-8 5875-25-2

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CAS号5875-25-2 2-溴丙酰胺 | CAS号78-97-7 乳腈 | CAS号107-12-0 丙腈 | CAS号107-13-1 丙烯腈 | CAS号506-68-3 溴化氰 | CAS号598-72-1 2-溴丙酸 | CAS号14904-46-2 3-amino-2-methy... | CAS号29668-61-9 (1-氰基乙基)膦酸二乙酯 | CAS号3264-99-1 propanenitrile | CAS号1617-17-0 2-氯丙腈 | CAS号7391-29-9 2-methyl-3-oxo-... | CAS号7663-76-5 2-氧代-1-吡咯烷PROPI... | CAS号98858-81-2 2-azidopropanen... | CAS号4468-47-7 2-甲基-3-氧代丁腈

📜乳腈置于吡啶,二溴亚砜,氯化亚砜体系中,化学反应生成2-溴丙腈
参考文献:与某些杂环天然产物有关的c-糖基化合物的合成和"异构化"
标题:与某些杂环天然产物有关的c-糖基化合物的合成和"异构化"
摘要:摘要2,3-O-异亚丙基-D-呋喃核糖(13)与稳定的wittig试剂ph 3Pc(me)co 2 Me(14)和ph 3Pc(me)cn(15)反应生成烯烃产物,用稀碱处理后,仅得到相应的具有β-D-端基异构体构型的脱水糖.用强碱处理这些动力学产物不会影响由14生成的酯,但由15生成的腈在平衡为4:1时产生的β-α-端基异构体比率.13与ph 3Pchcome的反应直接导致β-和α-D异构体的比例为7:3,长时间暴露于碱中后该比例变为1:4.用wittig试剂ph 3Pchcoch2 Co 2 Et处理4,6-O-亚乙基-D-吡喃葡萄糖直接导致1:1种脱水糖的异构体的混合物,其中β-酮酯残基连接在(原始)异头中心.通过用碱处理不能改变该端基异构体形式的比例,但是可以除去亚乙基保护基,并且将得到的四醇在三级位置上进行三苯甲基化.
Doi:10.1016/s0008-6215(00)90877-2

专利信息

专利号:US-11459303-B2
优先权日:2019-06-21
标题 :Process for the synthesis of lofexidine
发明人：DONNOLA MONICA; BAROZZA ALESSANDRO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:Disclosed is a process for the synthesis of lofexidine of formula (I) and the hydrochloride salt thereof (II), from ethyl 2-(2,6-dichlorophenoxy)propionate (III) and ethylenediamine in the presence of tetravalent titanium alkoxides, preferably titanium isopropoxide, in an apolar solvent such as toluene. A further object of the present invention is a process for the preparation of the intermediate ethyl 2-(2,6-dichlorophenoxy)propionate (III) from 2,6-dichlorophenol and ethyl 2-chloropropionate in the presence of a polar aprotic solvent and an alkali or alkaline earth carbonate salt, preferably potassium carbonate. Both processes are more cost-effective and more easily industrially scalable than the known procedures, thus enabling the active ingredient to be obtained with high yields at a limited cost.

专利号:US-6162882-A
优先权日:1996-07-10
标 题:Preparation of novel homo- and copolymers using atom transfer radical polymerization
发明人：MATYJASZEWSKI KRZYSZTOF; COCA SIMION; GAYNOR SCOTT G; NAKAGAWA YOSHIKI; JO SEONG MU
权利人:UNIV CARNEGIE MELLON
摘要:The present invention is directed to a process of atom (or group) transfer radical polymerization for the synthesis of novel homopolymer or a block or graft copolymer, optionally containing at least one polar group, with well defined molecular architecture and narrow polydipersity index, in the presence of an initiating system comprising (i) an initiator having a radically transferrable atom or group, (ii) a transition metal compound, and (iii) a ligand, the present invention is also directed to the synthesis of a macromolecule having at least two halogen groups which can be used as a macroinitiator component (i) to subsequently form a block or graft copolymer by an atom or group transfer radical polymerization process; the present invention is also directed to a process of atom or group transfer radical polymerization for the synthesis of a branched or hyperbranched polymer; in addition, the present invention is directed to a process of atom or group transfer radical polymerization for the synthesis of a macroinitiator which can subsequently be used to produce a block or graft copolymer.

专利号:US-2013165350-A1
优先权日:2011-12-22
标 题:Surface linkers for array synthesis
发明人：KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR
权利人:KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR; AFFYMETRIX INC
摘要:The present invention provide several methods of derivatizing a surface of a support with one or more linkers thus providing a suitable platform for synthesis of a polymer array, particular a nucleic acid array. Some methods derivatize a surface with a self-assembled monolayer (SAM) of a linker. The SAM confers advantages of hydrolytic stability, broad compatibility with synthesis and detection chemistries, and reduced emergence of latent functional groups during polymer array synthesis. Substrates can also be derivatized with multi-layers of SAMs providing greater hydrolytic stability. Substrates can also be derivatized by synthesizing a linker in situ on the substrate by atom transfer radical polymerization of functional and functional monomers. Appropriate selection of monomers reduces emergence of latent functional groups in subsequent array synthesis.

专利号:US-9512250-B2
优先权日:2012-02-23
标 题 :Manganese catalyzed photopolymerization of fluorinated monomers
发明人：ASANDEI ALEXANDRU D
权利人:UNIV CONNECTICUT
摘要:The disclosure discloses initiating systems for the radical polymerization of alkenes, and especially fluorine substituted alkenes. The polymerization is catalyzed by a metal carbonyl, preferably manganese carbonyl. The polymerization is initiated directly from alkyl halides at room temperature under visible white light. The polymers also allow the synthesis of block copolymers. The process comprises polymerizing at least one alkene monomer in the presence of a halide radical initiator, carbonyl catalyst and a solvent, under reaction conditions and for a time sufficient to polymerize the at least one alkene monomer to form a polymer. The present disclosure provides a method for living polymerization of alkene monomers which provides a high level of macromolecular control over the polymerization process and which leads to uniform and controllable polymeric products. This disclosure also provides a method for activating any halide (Cl, Br, I) chain ends of such polymers for the synthesis of block copolymerizations.

专利号:US-12053529-B2
优先权日:2018-08-01
标题:Amino-reactive positively charged ATRP initiators that maintain their positive charge during synthesis of biomacro-initiators
发明人：RUSSELL ALAN J; MURATA HIRONOBU
权利人:UNIV CARNEGIE MELLON
摘要:Provided herein are materials and methods that include utilizing atom transfer radical polymerization (ATRP) initiator molecules that maintain a positive charge during biomacro-initiator synthesis.

专利号:US-8192762-B2
优先权日:2005-06-01
标题 :Preparation of soluble and colloidal molecularly imprinted polymers by living polymerization
发明人：KARIM KHALKU; PILETSKY SERGEY ANATOLIYOVICH; PILETSKA OLENA VOLODIMIRIVNA; TURNER ANTHONY PETER FRANCIS; CHIANELLA IVA; GUERRIERO ANTONIO RICARDO LEONARDO
权利人:KARIM KHALKU; PILETSKY SERGEY ANATOLIYOVICH; PILETSKA OLENA VOLODIMIRIVNA; TURNER ANTHONY PETER FRANCIS; CHIANELLA IVA; GUERRIERO ANTONIO RICARDO LEONARDO; UNIV CRANFIELD
摘要:The present invention describes a method for synthesis of relatively low molecular weight imprinted polymers using living polymerization, and their application in analytical chemistry, pharmacology, medicine and the food industry. Specifically the low-molecular weight polymers are synthesized by the polymerization of functional monomers in the presence of a template, such as a biological receptor, enzyme, nucleic acid, cell, virus, microorganism, tissue sample or drug using living initiator. The conditions of living polymerization ensure a relatively small size of synthesized molecules. Synthesized in this way molecules (dimers, oligomers, polymers, or their mixture) have a higher affinity to the template than the original monomers and can rebind it in vitro and/or in vivo. As a further aspect of the present invention, polymers synthesized as described above can be used as drugs in pharmacology and medicine, as receptor-specific ligands in analytical chemistry (sensors, assays), and for separations in the biotechnology, pharmaceutical and food industries.