专利号:US-8822702-B2 优先权日:2002-12-20 标 题 :Synthesis of amines and intermediates for the synthesis thereof 发明人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL 权利人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL; BASF SE 摘要:The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, n nor especially of amides of the formula II,n n nwherein the symbols have the meanings given in the specification, as well as other intermediates and compounds useful in the synthesis of tryptamines and other substances mentioned in the title. The synthesis methods and intermediates are useful in the synthesis of pharmaceuticals.
专利号:WO-2025119975-A1 优先权日:2023-12-04 标 题:A method for synthesis of harmine 发明人:HETT ROBERT; GRAB HANUSCH; LAGOUTTE ROMAN 权利人:RECONNECT LABS AG 摘要:The invention relates to a method of synthesis of a compound of formula (I), harmine, according to the method comprising a step of transforming the compound of formula (II), into the compound of formula (I). The invention further relates to a compound of formula (II), which is an intermediate in synthesis of harmine according to the present invention.
专利号:EP-0842924-B1 优先权日:1996-11-14 标 题 :Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists 发明人:WRIGHT STEPHEN WAYNE 权利人:PFIZER 摘要:The present invention relates to certain compounds of the formula (I), which are useful in the synthesis of certain beta -adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), wherein R<1>, R<2> and R<4> are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), R<1>, R<2> and Y<2*> are defined herein.o
专利号:US-2007249867-A1 优先权日:2004-08-11 标题 :Method for Synthesis of Aromatic Amine 发明人:NAKASHIMA HARUE; KAWAKAMI SACHIKO 权利人:NAKASHIMA HARUE; KAWAKAMI SACHIKO 摘要:One embodiment of the present invention provides a method for synthesis of substituted secondary amine by the reaction of aniline with aryl halide by using a Pd catalyst including (t-Bu) 3 P as a ligand.
专利号:WO-2024073221-A1 优先权日:2022-09-29 标题:Synthesis of palladium(0) phosphine complexes 发明人:MACQUEEN PRESTON; GHORAI SUBIR; COLACOT THOMAS 权利人:SIGMA ALDRICH CO LLC 摘要:Provided is an optimized process for the synthesis of palladium(O) phosphine complexes. The process described herein is characterized by a more efficient reaction control, high yield and purity, the use of readily available starting materials, and savings in reaction time and steps, thereby offering increased sustainability when compared to processes reported in the state of the art.
专利号:US-2025101006-A1 优先权日:2022-01-31 标题:Process for the synthesis of pyrazolyl derivatives useful as anti-cancer agents 发明人:BAENZIGER MARKUS; GALLOU FABRICE; GUO FENGFENG; HÄNGGI RUDOLF; HAN ENJIAN; JORDINE GUIDO; LI JIALIANG; LIU WEIPENG; MIAO BUKEYAN; RONG SHAOFENG; SANTANDREA ERNESTO; SCHIRNER PAUL BERND; SHEN XIAODONG; WANG CAN; ZHANG HAO 权利人:NOVARTIS AG 摘要:The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors. The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I). The invention provides a process for preparing Intermediate B6* comprising reacting Intermediate B4* with Intermediate B5* in an atroposelective coupling reaction, using a chiral catalyst.