CAS: 117924-33-1; Di-Tert-Butyl Diethylphosphoramidite

相似化合物

137348-86-8 126429-21-8 916996-01-5

上下游产品

CAS号1069-08-5 二氯(二乙氨基)膦 | CAS号75-65-0 叔丁醇 | CAS号15205-62-6 Phosphorous aci... | CAS号118818-64-7 BIS(DIETHYLAMIN... | CAS号78543-77-8 di-tert-butylph... | CAS号109-89-7 二乙胺 | CAS号118818-65-8 tert-butyl diet... | CAS号20224-50-4 TRI-TERT-BUTYLP... | CAS号33494-81-4 磷酸二叔丁基酯 | CAS号145545-15-9 [3,4-ditert-but... | CAS号68695-42-1 ditert-butyl pr... | CAS号68695-43-2 ditert-butyl 2-...

三-叔-丁基亚磷酸置于三氯化磷体系中,用 乙醚 用作溶剂,化学反应生成N,N-二乙基亚磷酰胺二叔丁酯
参考文献:亚磷酰胺作为o-磷酸化剂及其反应性的研究
标题:亚磷酰胺作为o-磷酸化剂及其反应性的研究
摘要:摘要 O-磷酸化肽和氨基酸在生命系统中很重要.本文采用两种方法合成了二烷基-N,N-二烷基亚磷酰胺(Ddpa) 3 .在四唑的存在下,Ddpa与相应氨基酸的羟基反应,然后氧化,以非常好的收率获得o-磷酰基氨基酸甲酯.还介绍了 Ddpa 反应性的系统研究.
Doi:10.1080/10426500008045253

专利信息

专利号:US-7301006-B2
优先权日:2002-07-16
标 题 :Methods and materials for the synthesis of modified peptides
发明人：YOUNG TRAVIS G; KIESSLING LAURA L
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Methods and protected amino acids useful as building blocks (protected monomers) for the synthesis of peptides and proteins that are selectively modified at one or more side-chain hydroxyl groups. Azide-bearing protecting groups allow the selective deprotection of side-chain hydroxyl groups of amino acids after synthesis of a peptide. Reaction conditions for removal of the azide-bearing protecting group can be selected which are substantially orthogonal to those that will remove α-amino protecting groups typically employed in peptide synthesis, such that hydroxyl groups protected with the azide-bearing protecting group remain protected during synthesis of the peptide chain. Various protecting groups which are readily available can be used for protecting potentially reactive side chain groups of amino acids in the peptide or protein to be modified. Preferred side-chain protecting groups are chemically distinguishable from the azide-bearing protecting group and substantially orthogonal reaction conditions can be selected such that side-chain protection of other amino acids is maintained when the azide-bearing protecting group is removed. The use of the azide-bearing protecting group of this invention for one or more hydroxy amino acids during peptide synthesis allows the selective unmasking of those azide-protected side-chain hydroxyl groups and selective modification of the hydroxyl groups that are selectively unmasked. The methods and materials herein are particularly used in synthesis of sulfated, phosphorylated and glycosylated peptides and proteins. Kits and methods of synthesizing a modified peptide or protein using the kits are also provided.

专利号:US-10730904-B2
优先权日:2012-11-14
标 题:Method for liquid-phase synthesis of nucleic acid
发明人：NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO
权利人:TAKEDA PHARMACEUTICALS CO
摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

专利号:US-2024368164-A1
优先权日:2021-04-28
标 题 :Purine nucleosides, their intermediates, and methods of preparation thereof
发明人：RAVI RAMA SURESH; JACOBSON KENNETH A; POE RUSSELL BIRCH
权利人:ASTROCYLE PHARMACEUTICALS INC; US HEALTH
摘要:The present invention provides purine nucleoside analog compounds and methods of use thereof for treatment of certain injuries, disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries. The present invention further provides methods of synthesizing such compounds, and intermediates useful in the synthesis of such compounds.

专利号:US-7557096-B2
优先权日:1998-01-09
标题 :Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof
发明人：PETTIT GEORGE R; RHODES MONTE R
权利人:UNIV ARIZONA
摘要:Combretastatin A-4 has been previously selected for pre-clinical development as antineoplastic agent. However, it is essentially insoluble in water. New water soluble derivatives of combretastatin A-4 and its qualified analogs have been discovered and synthesized through a multistage process using other derivatives of combretastatin A-4 as intermediates. These water soluble derivatives are herein denominated as “Combretastatin A-4 Prodrugsâ€?.

专利号:US-11999693-B2
优先权日:2015-09-24
标 题:Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment
发明人：EDINGER AIMEE L; HANESSIAN STEPHEN
权利人:UNIV CALIFORNIA; THE UNIV DE MONTREAL
摘要:Small molecules comprised of azacyclic constrained sphingolipid-like compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.

专利号:WO-2012059568-A1
优先权日:2010-11-05
标 题:Novel water-soluble indolobenzazepine molecules demonstrating antimitotic, antivascular, and antitumor activities in vivo
发明人：DODD ROBERT; BAKALA JOANNA; LIU JIANMIAO; BIGNON JEROME; PONS VALERIE; BEAUMONT STEPHANE
权利人:CENTRE NAT RECH SCIENT; DODD ROBERT; BAKALA JOANNA; LIU JIANMIAO; BIGNON JEROME; PONS VALERIE; BEAUMONT STEPHANE
摘要:The present patent application relates to indolobenzazepine derivatives having an antitumor activity, to the synthesis thereof, and to the use thereof. In particular, the present patent application relates to the stereocontrolled synthesis of C5-substituted indolobenzazepinones enabling only one of the two possible C5 isomers to be obtained, as well as water-soluble analogs making it possible to demonstrate the very high effectiveness of said molecules in reducing the size of tumors in vivo .