CAS: 116470-67-8; 2-(Trifluoromethyl)Pyrimidine

相似化合物

845618-08-8 799557-86-1 73418-87-8

上下游产品

2-chloropyrimidine dibromodifluoromethane sodium 2,2,2-trifluoroacetate 2-bromopyrimidine

2-氯嘧啶 以46%的收率获得
参考文献:Clark,James H.;Mcclinton,Martin A.,J. Chem. Soc. Chem. Commun.,(1988) N 10,638-639
标题:Clark,James H.;Mcclinton,Martin A.,J. Chem. Soc. Chem. Commun.,(1988) N 10,638-639

专利信息

专利号:US-2023399302-A1
优先权日:2020-10-29
标题:Process for the preparation of heteroaryl-substituted sulfur(vi) compounds
发明人：LOPCHUK JUSTIN M; SHULTZ ZACHARY P; SCATTOLIN THOMAS
权利人:H LEE MOFFITT CANCER CT & RES
摘要:The present disclosure provides processes for the synthesis of organic compounds, in particular processes for the synthesis of heteroaryl-substituted sulfur(VI) compounds by nucleophilic aromatic substitution.

专利号:WO-2014126954-A1
优先权日:2013-02-13
标题:Regioselective synthesis of substituted pyrimidines
发明人：CASTELHANO ARLINDO L; RECHKA JOSEF A; SENANAYAKE CHANDRAWANSHA; DEVANATHAN KRISHNASWAMY; GNANAVELU KARUNANIDHI
权利人:OSI PHARMACEUTICALS LLC
摘要:Disclosed are compounds of the Formula I:(I) where R 1 , R 4 , and R 5 are described herein, and methods of making the compounds, including regioselective functionalization.

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:KR-20060030918-A
优先权日:2003-09-05
标题 :Selective synthesis of cf3-substituted pyrimidines

专利号:TW-201124385-A
优先权日:2009-08-14
标 题:Selective synthesis of functionalized pyrimidines

专利号:US-8828907-B2
优先权日:2009-03-25
标题:Active ingredient combinations having insecticidal and acaricidal properties
发明人：HUNGENBERG HEIKE; JESCHKE PETER; VELTEN ROBERT; THIELERT WOLFGANG
权利人:HUNGENBERG HEIKE; JESCHKE PETER; VELTEN ROBERT; THIELERT WOLFGANG; BAYER CROPSCIENCE AG
摘要:The present invention relates to novel active compound combinations comprising, firstly, at least one known compound of the formula (I) n nin whichn nR 1 and A have the meanings given in the descriptionn nand, secondly, at least one further known active compound from the class of the chitin synthesis inhibitors, the molting hormone agonists or other classes, which combinations are highly suitable for controlling animal pests such as insects and unwanted acarids.