CAS: 99-06-9; 3-Hydroxybenzoic Acid

上下游产品

CAS号585-76-2 3-溴苯甲酸 | CAS号25487-66-5 3-羧基苯硼酸 | CAS号618-51-9 间碘苯甲酸 | CAS号108-39-4 间甲酚 | CAS号1700-37-4 3-苄氧基苯甲醛 | CAS号138-59-0 莽草酸 | CAS号83573-28-8 methyl 2-(((1R,... | CAS号17119-15-2 3-羟基扁桃酸 | CAS号100-83-4 间羟基苯甲醛 | CAS号108593-47-1 3-乙氧基苯甲酸甲酯 | CAS号10476-50-3 3-hydroxybenzoi... | CAS号34113-69-4 4-氯-3-羟基苯甲酸 | CAS号51786-10-8 2-氯-3-羟基苯甲酸 | CAS号56961-30-9 2-氯-5-羟基苯甲酸 | CAS号2150-41-6 2,4-二甲氧基苯甲酸甲酯 | CAS号606-45-1 2-甲氧基苯甲酸甲酯 | CAS号5368-81-0 3-甲氧基苯甲酸甲酯 | CAS号121-98-2 茴香酸甲酯 | CAS号2150-38-1 3,4-二甲氧基苯甲酸甲酯

间甲酚置于ferredoxin Reductase,Ferredoxin,4-Methylphenyl Phosphate Synthase,P450 Monooxygenase,Nicotinamide Adenine Dinucleotide Phosphate,Nicotinamide Adenine Dinucleotide,5'-三磷酸腺苷,Magnesium Chloride,Manganese(Ll) Chloride,Alcohol Dehydrogenase,Aldehyde Dehydrogenase,Phosphohydrolase体系中,用 Aq. Buffer 作为反应溶剂,化学反应 4.0H,以41.4%的收率获得产物间羟基苯甲酸
参考文献:通过化学模拟生物催化系统选择性氧化烷基酚中的脂肪族ch键
标题:通过化学模拟生物催化系统选择性氧化烷基酚中的脂肪族ch键
摘要:烷基酚中脂族c-h键的选择性氧化不仅在可用于合成各种下游化学产品的功能化中间体的产生中,而且在这些对环境有害的化合物的生物降解中都起着重要作用.化学选择性,区域选择性和立体选择性;可控性 环境影响是烷基酚化学氧化的主要挑战.在这里,我们报道了一种源自革兰氏阳性细菌谷氨酸棒杆菌的独特化学模拟生物催化系统的发展.由crehi(用于安装磷酸酯导向/锚定基团),Crejef / Creg / Crec(用于烷基酚的氧化)和cred(用于导向/锚定基团卸载)组成的系统能够选择性地氧化脂族c-H键的p-和米以可控的方式烷基化酚.此外,与两种代表性底物复合的中央p450生物催化剂crej的晶体结构为其底物的柔韧性和反应选择性提供了重要的结构见解.
DOI:10.1073/pnas.1702317114

专利信息

专利号:US-8357819-B2
优先权日:2007-05-11
标 题 :Method for the synthesis of (Z)-3-[2-butoxy-3′-(3-heptyl-1-methyl-ureido)-biphenyl-4-yl]-2-methoxy-acrylic acid
发明人：BOITEAU JEAN-GUY
权利人:GALDERMA RES & DEV; BOITEAU JEAN-GUY
摘要:The invention relates to a process for the synthesis of (Z)-3-[2-butoxy-3′-(3-heptyl-1-methylureido)biphenyl-4-yl]-2-methoxyacrylic acid of formula (I): n nand also to the process for the synthesis of the reaction intermediates of general formula (XII), and to the said compounds when R2 is chosen from the methyl, trifluoromethyl, phenyl and 4-tolyl radicals:

专利号:US-6872535-B2
优先权日:1998-05-20
标题:Three-dimensional array of supports for solid-phase parallel synthesis and method of use
发明人：BAUM STEPHEN A
权利人:AVENTIS PHARMA INC
摘要:A three-dimensional (3D) array of solid-phase supports is adapted to provide parallel synthesis of a library of molecules with 3D diversity. Individual locations in the 3D array may be assigned to selected molecules in the library such that molecules may be synthesized at and retrieved from such locations. Also, the supports include aperture walls in stacked plates; the supports may be suspended within stacked plate apertures; the 3D array include discrete supports arranged in columns in one or more wells; the supports include tube inner walls or be suspended in tubes, the tubes being secured in stacked, two-dimensional (2D) frameworks; or the supports include beads contained in porous enclosures having non-porous side walls and being secured in stacked, 2D frameworks. A support transfer device enables transfer of solid-phase supports used in a 3D array. Such apparatus includes: a rack of rods sized to be inserted through supports and a mechanism to prevent supports from coming off the rack; tubes connected to a vacuum manifold to suction supports one Z plane at a time; or a transfer block having recesses to receive one or more support and at least one gate withholding supports from passing through the gate when in a closed position. A method of 3D synthesis includes: a) functionalizing solid-phase supports; b) placing supports in a 3D array; and c) performing parallel synthesis with 3D diversity. At least one unique R 1 group member may be assigned to each Z plane.

专利号:US-11773118-B2
优先权日:2019-02-21
标 题:Methods of making high enantioselective secondary alcohols
发明人：YU CHENG-DER TONY; HSIEH YIH-HUANG; LIN SHU-YI; CHAO CHIN-SHENG; HSIEH YIN-CHENG; LAI MING-TAIN
权利人:OBI PHARMA INC
摘要:A new process to synthesis of compound OBI-3424 R-form and S-form products is provided. The “R-formâ€? compound OBI-3423 was first synthesized with 48% overall yield from compound OBI-3424-5 by installation of the labile phosphate motif at later stage. The stereo chemistry is established by 5 steps chemo-enzyme combination synthesis to afford 99% optical purity. After then, the “S-formâ€? compound OBI-3424 is prepared with improving overall yield of 54% from compound OBI-3424-5. The stereo chemistry is established by 4 steps combination of chemo-enzyme synthesis with excellent optical purity of 99%.

专利号:US-8304409-B2
优先权日:2002-07-03
标 题:Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
权利人:EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI; NICOX SA
摘要:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.

专利号:US-2006052577-A1
优先权日:2001-02-06
标题:Methods of synthesis of polymers and copolymers from natural products
发明人：SWIFT GRAHAM; WESTMORELAND DAVID G; HUGHES KATHLEEN
权利人:SWIFT GRAHAM; WESTMORELAND DAVID G; HUGHES KATHLEEN
摘要:Described are polymers and copolymers containing sorbitol, citric acid, starch, aspartic acid, succinic anhydride, adipic acid mixtures thereof, methods of their synthesis and their uses.

专利号:US-2002192767-A1
优先权日:1999-10-13
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli . Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.