CAS: 95-73-8; 2,4-Dichlorotoluene

上下游产品

CAS号108-88-3 甲苯 | CAS号106-43-4 对氯甲苯 | CAS号59293-67-3 2,4-二氯苄硫醇 | CAS号50-84-0 2,4-二氯苯甲酸 | CAS号30895-98-8 4-methylphenylt... | CAS号1193-72-2 2,4-二氯溴苯 | CAS号544-97-8 二甲基锌 | CAS号320-60-5 2,4-二氯三氟甲苯 | CAS号95-80-7 2,4-二氨基甲苯 | CAS号95-49-8 邻氯甲苯 | CAS号50-82-8 2,4,5-三氯苯甲酸 | CAS号50-84-0 2,4-二氯苯甲酸 | CAS号94-99-5 2,4-二氯氯苄 | CAS号118-90-1 邻甲基苯甲酸 | CAS号5162-82-3 3-氯-4-甲基苯甲酸 | CAS号7499-06-1 5-氯-2-甲基苯甲酸 | CAS号99-94-5 对甲基苯甲酸 | CAS号95-49-8 邻氯甲苯 | CAS号22682-29-7 2-甲基苯甲酮 | CAS号1943-88-0 4-甲基-异酞腈

2,4-二氯苯甲酸置于dimethyl Sulfide Borane体系中,用 氯苯 作为反应溶剂,以25%的收率获得产物2,4-二氯甲苯
参考文献:硼烷-二甲基硫醚络合物与芳香酸的反应:与甲基化合物或苄基二甲基sulph盐接触.
标题:硼烷-二甲基硫醚络合物与芳香酸的反应:与甲基化合物或苄基二甲基sulph盐接触.
摘要:在某些条件下,硼烷二甲基硫醚(bms)与芳族羧酸的作用会导致相应的甲基衍生物,或者在bf 3存在的情况下会导致苄基二甲基sulph盐.
DOI:10.1016/0040-4039(91)85078-J

专利信息

专利号:US-6117992-A
优先权日:1996-08-26
标题 :Reagents and process for synthesis of oligonucleotides containing phosphorodithioate internucleoside linkages
发明人：IYER RADHAKRISHNAN P
权利人:HYBRIDON INC
摘要:The invention provides new methods for synthesizing oligonucleotides containing at least one, and preferably all phosphorodithioate internucleoside linkages with less than 5% phosphoromonothioate contamination. This level of purity in the synthesis of phosphorodithoates has previously been very difficult to achieve with all existing methods. The invention further provides phosphorothioamidite nucleoside synthons comprising a sulfur protecting group that is stable under normal oligonucleotide synthesis conditions.

专利号:US-11999757-B2
优先权日:2017-11-01
标 题:Synthesis of boronate ester derivatives and uses thereof
发明人：BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J
权利人:MELINTA SUBSIDIARY CORP
摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

专利号:US-2008125587-A1
优先权日:2006-05-25
标 题 :Synthesis of triazole compounds that modulate HSP90 activity
发明人：CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
权利人:CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
摘要:The present invention provides novel methods of preparing triazole compounds which inhibit the activity of Hsp90. One embodiment of the invention is directed to methods for preparing a triazole compound represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising the steps of: a) reacting an amide represented by the following Structural Formula: n n n n n n n n n n with a thionation reagent to form a thioamide; b) reacting the thioamide of step a) with hydrazine to form a hydrazonamide; c) reacting the hydrazonamide of step b) with a carbonylation or a thiocarbonylation reagent. n In one embodiment, the present invention is a method of synthesis of a compound of formula (IA) n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising reacting a compound of formula (IIA) n n n n n n n n n n with an oxidizing agent, thereby producing a compound of formula (IA). n The present invention is also directed to a method of preparing a compound or a tautomer thereof represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof. The method comprises the step of reacting a first starting compound represented by the following Structural Formula: n n n n n n n n n n in the presence of a mercuric salt, with a second starting compound represented by the following Structural Formula:

专利号:US-10669292-B2
优先权日:2014-05-05
标 题 :Synthesis of boronate salts and uses thereof
发明人：HECKER SCOTT; BOYER SERGE
权利人:REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.

专利号:US-5698741-A
优先权日:1995-05-25
标题 :Asymmetric synthesis of (-)6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
发明人：THOMPSON ANDREW S; CORLEY EDWARD G; GRABOWSKI EDWARD J J; YASUDA NOBUYOSHI
权利人:MERCK & CO INC
摘要:An improved synthesis of a highly potent HIV reverse transcription inhibitor is disclosed, involving an acetylide and a trifluoromethyl ketone which produces a chiral product in the presence of a chiral amino alcohol.

专利号:US-9315483-B2
优先权日:2007-09-13
标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
发明人：JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
权利人:CONCERT PHARMACEUTICALS INC
摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.