CAS: 93168-20-8; 1-(3-Phenylpropyl)Thiourea

该化合物是一种有机化合物,其特点是存在硫尿素功能组,由碳原子双层覆盖硫磺和单层覆盖氮原子组成;该化合物具有苯丙基化合物组,该组有助于其疏水特性和潜在的生物活动;该化合物在室温中一般是固体,在极地有机溶剂中可溶解;该硫尿素的存在表明在药用化学中,特别是在药物的开发方面可能应用,因为它能够形成氢链并与生物目标相互作用;此外,此类化合物可能表现出多种生物活动,包括抗扰动和抗微生物特性;应当遵守安全和处理预防措施,因为硫尿素可能是有毒的,并可能对健康造成危害.

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CAS号2627-27-2 3-苯基丙基硫代异氰酸酯 | CAS号2038-57-5 3-苯基丙基胺 | CAS号30684-05-0 3-苯基-1-丙胺盐酸盐 | CAS号861572-97-6 μ-disulfido-1,2...

合成工艺路线路线简述

  • 合成目标产物 1-(3-Phenylpropyl)-2-Thiourea 主要起始原料 Benzamide, N-[[(3-Phenylpropyl)Amino]Thioxomethyl]-
  • 145383-01-3 = 93168-20-8
    反应条件:1.1 Reagents: Hydrazine Hydrate (1:1); 3 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Preparation Of Pyrazines And Related Heterocycles As Antiviral Agents And Use Thereof
    参考文献:World Intellectual Property Organization]

    = 93168-20-8 [标题:Reaction Conditions
    标题:Preparation Of Hydroxamic Acids As Matrix Metalloprotease Inhibitors
    参考文献:World Intellectual Property Organization]

    145383-01-3 = 93168-20-8
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Ethanol,Water; 3 H,Reflux
    标题:Clobenpropit Analogs As Dual Activity Ligands For The Histamine H3 And H4 Receptors: Synthesis,Pharmacological Evaluation,And Cross-Target Qsar Studies
    作者:Lim,Herman D.; Istyastono,Enade P.; Van De Stolpe,Andrea; Romeo,Giuseppe; Gobbi,Silvia; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2009 卷标:17(11) 页码:3987-3994]

    2038-57-5 + 102368-13-8 = 93168-20-8
    反应条件:1.1 Solvents: Dichloromethane; 0 °C -> Rt1.2 Reagents: Ammonium Hydroxide Solvents: Water
    标题:Design And Synthesis Of Piperazinylpyrimidinones As Novel Selective 5-Ht2C Agonists
    作者:Andrews,Mark D.; Green,Martin P.; Allerton,Charlotte M. N.; Batchelor,David V.; Blagg,Julian; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2009 卷标:19(18) 页码:5346-5350]

    2038-57-5 + 1762-95-4 = 93168-20-8
    反应条件:1.1 Reagents: Benzoyl Chloride Solvents: Acetone; 5 Min,Rt; 15 Min,60 °C1.2 Solvents: Acetone; 15 Min,Rt; 30 Min,60 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; 20 Min,70 °C
    标题:Structural Requirement(S) Of N-Phenylthioureas And Benzaldehyde Thiosemicarbazones As Inhibitors Of Melanogenesis In Melanoma B 16 Cells
    作者:Thanigaimalai,P.; Le Hoang,Tuan Anh; Lee,Ki-Cheul; Bang,Seong-Cheol; Sharma,Vinay K.; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2010 卷标:20(9) 页码:2991-2993]

    = 93168-20-8 [标题:Reaction Conditions
    标题:Platelet Aggregation Inhibiting And Anticoagulant Effects Of Oligoamines. Xxii. Bisoxazol-,Bisimidazol-,Bisthiazol- And Oligo-1,2,4-Thiadiazolimines
    作者:Rehse,Klaus; Martens,Antje
    参考文献:Archiv Der Pharmazie (Weinheim 日期:1993 卷标:326(7) 页码:399-404]

    = 93168-20-8 [标题:Reaction Conditions
    标题:Isothiourea Analog Of Histamine As Potent Agonists Or Antagonists Of The Histamine H3-Receptor
    作者:Van Der Goot,H.; Schepers,M. J. P.; Sterk,G. J.; Timmerman,H.
    参考文献:European Journal Of Medicinal Chemistry 日期:1992 卷标:27(5) 页码:511-17
📜3-苯基-1-丙胺盐酸盐置于氨,碳酸氢钠体系中,用 甲醇,氯仿 作为反应溶剂,化学反应 12.5H,反应生成 1-(3-苯丙基)-2-硫脲
参考文献:Synthesis Of Thiophene-2-Carboxamidines Containing 2-Amino-Thiazoles And Their Biological Evaluation As Urokinase Inhibitors
标题:Synthesis Of Thiophene-2-Carboxamidines Containing 2-Amino-Thiazoles And Their Biological Evaluation As Urokinase Inhibitors
摘要:The Serine Protease Urokinase (Upa) Has Been Implicated In The Progression Of Both Breast And Prostate Cancer. Utilizing Structure Based Design,The Synthesis Of A Series Of Substituted 4-[2-Amino-1,3-Thiazolyl]-Thiophene-2-Carboxamidine Is Described. Further Optimization Of This Series By Substitution Of The Terminal Amine Yielded Urokinase Inhibitors With Excellent Activities. (C) 2001 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0960-894X(01)00102-0

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合成参考文献


参考文献:10.1016/j.bmcl.2010.02.067
摘要:Thanigaimalai P, Hoang TA, Lee KC, Bang SC, Sharma VK, Yun CY, Roh E, Hwang BY, Kim Y, Jung SH. Structural requirement(s) of N-phenylthioureas and benzaldehyde thiosemicarbazones as inhibitors of melanogenesis in melanoma B 16 cells. Bioorg Med Chem Lett. 2010 May 01;20(9):2991–3. doi: 10.1016/j.bmcl.2010.02.067.
参考文献:10.1016/j.bmcl.2011.09.024
摘要:Thanigaimalai P, Lee KC, Sharma VK, Joo C, Cho WJ, Roh E, Kim Y, Jung SH. Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6824–8. doi: 10.1016/j.bmcl.2011.09.024.
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