CAS: 90899-22-2; P-Hydroxybenzoylecgonine

上下游产品

芽子碱甲酯 Methyl Ecgonine 01/09/7143
芽子碱 Ecgonine 481-37-8

📜盐酸古柯碱置于盐酸,Sodium Hydroxide,Sodium Carbonate体系中,用 甲醇,乙醚,苯 作为反应溶剂,化学反应 43.0H,反应生成 P-羟基苯甲酰基芽子碱
参考文献:Radioimmunoassay Of Benzoylecgonine In Samples Of Forensic Interest
标题:Radioimmunoassay Of Benzoylecgonine In Samples Of Forensic Interest
摘要:摘要:本文描述了一种简单经济的血液或尿液苯甲酰异可卡因放射免疫测定方法.溶血,分解,常见的抗凝剂和氟化钠不会影响结果.商业上可获得的抗血清以1:600的稀释度使用.示踪剂是放射性碘化的对羟基苯甲酰异可卡因.它是通过将对乙酰基苯甲酸酐与甲基异可卡因反应,然后进行温和水解和iodo-Gen方法的放射性碘化制备的.该产品在一次性硅胶柱上纯化,其比活性约为30 Tbq Mmol−1.聚乙二醇用于分离测定中的结合和游离分数.剂量-反应曲线的范围为0-400 Ng Ml−1 苯甲酰异可卡因.该测定方法对苯甲酰异可卡因具有很大的特异性.可卡因,异可卡因,甲基异可卡因和肉桂酰可卡因的交叉反应轻微或可以忽略不计.测定方法的间测变异系数为7.5%,从"掺假"的血液中回收苯甲酰异可卡因的百分比为103%.对于血液和尿液,"截止值"为20 Ng Ml−1 苯甲酰异可卡因.放射免疫测定和高效液相色谱法的结果是一致的.
DOI:10.1111/j.2042-7158.1984.Tb06930.X

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.