CAS: 90-01-7; 2-(Hydroxymethyl)Phenol

上下游产品

CAS号90-02-8 水杨醛 | CAS号89-95-2 邻甲基苄醇 | CAS号50-00-0 甲醛 | CAS号108-95-2 苯酚 | CAS号82112-31-0 1-(tert-butyldi... | CAS号119-36-8 水杨酸甲酯 | CAS号50-78-2 阿司匹林 | CAS号77023-20-2 7-oxabicyclo[4.... | CAS号888958-33-6 6-iodo-2,2-dime... | CAS号10419-35-9 2-乙氧基苯并二氢吡喃 | CAS号112055-31-9 4H-1,3-benzodio... | CAS号119-36-8 水杨酸甲酯 | CAS号111080-48-9 (2-羟基甲基苯氧基)-乙酸乙酯 | CAS号106276-04-4 [2-(2-吗啉乙氧基)苯基]甲醇 | CAS号367-12-4 2-氟苯酚 | CAS号4481-51-0 2-(((2-hydroxyb... | CAS号3526-45-2 2-(苯胺基甲基)苯酚 | CAS号146952-30-9 [2-(hydroxymeth... | CAS号94-67-7 水杨醛肟

阿司匹林置于tetrabutylammonium Borohydride体系中,用 二氯甲烷 作为反应溶剂,以69%的收率获得产物水杨醇
参考文献:四烷基硼氢化铵还原羧酸
标题:四烷基硼氢化铵还原羧酸
摘要:摘要四烷基硼氢化铵仅使用化学计量量的氢化物并且在不存在任何路易斯酸的情况下以非常好的产率将羧酸还原为相应的醇.
DOI:10.1080/00397910008087107

专利信息

专利号:US-8669356-B2
优先权日:2009-10-21
标 题 :Linker and support for solid phase synthesis of nucleic acid
发明人：HAYAKAWA YOSHIHIRO; TSUKAMOTO MASAKI; MORI KENJIRO; MINOMI KENJIRO; MAETA ERI; KONISHI TATSUYA
权利人:HAYAKAWA YOSHIHIRO; TSUKAMOTO MASAKI; MORI KENJIRO; MINOMI KENJIRO; MAETA ERI; KONISHI TATSUYA; NITTO DENKO CORP; UNIV NAGOYA NAT UNIV CORP
摘要:The invention provides a universal linker capable of synthesizing nucleic acid having a phosphate group at the 3′ terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. The linker for solid phase synthesis of nucleic acid contains a compound represented by at least one of the following formulae n nwherein each symbol is as defined in the specification.

专利号:US-2009221568-A1
优先权日:2005-11-04
标题:Synthesis of Inhibitors of FtsZ
发明人：SHAW JARED; URGAONKAR SAMEER; RAYCHAUDHURI DEBABRATA; LA PIERRE HENRY
权利人:SHAW JARED; URGAONKAR SAMEER; RAYCHAUDHURI DEBABRATA; LA PIERRE HENRY
摘要:FtsZ, the bacterial analog of tubulin, is a promising new target for developing new antibiotics. It has been shown that polyphenols inhibit the GTPase activity of FtsZ, thereby inhibiting Z-ring formation during mitosis. The present invention provides novel polyphenols compounds, which can be accessed by the synthesis of dichamametin and 2′″-hydroxy-5″-benzylisouvarinol-B as described herein. These novel compounds are useful in treating infections, particularly infections caused by gram-positive organisms. Methods of preparing the inventive compounds are also provided. The compounds are prepared by the benzylation of pinocembrin or chrysin core structure. Pharmaceutical compositions and method of using the compounds to treat disease are also provided. These compounds may be screened for antimicrobial activity as well as other biological activities such as anti-neoplastic, anti-inflammatory, immunosuppressive, and cytotoxic activity.

专利号:US-6525061-B1
优先权日:1999-11-16
标题 :Methods for the solid phase synthesis of 2-amino-4(H)-quinazolinone derivatives
发明人：GOPALSAMY ARIAMALA; YANG HUI Y
权利人:WYETH CORP
摘要:The present invention relates to solid phase synthesis of substituted 2-amino-4(H)-quinazolinone compounds of formula (I):having pharmacological activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

专利号:US-8350022-B2
优先权日:2008-04-04
标题 :Method for the stereoselective synthesis of phosphorus compounds
发明人：MEIER CHRIS; THOMANN JENS O
权利人:UNIV HAMBURG; MEIER CHRIS; THOMANN JENS O
摘要:The present invention relates to a method for stereoselective synthesis of phosphorus compounds, whereby in the first reaction step a chiral auxiliary on the phosphorus atom of phosphoryl chloride, thiophosphoryl chloride or phosphorus trichloride is covalently bonded, the product from the first reaction step is reacted in the following step with an alcohol, thiol, or amine as the nucleophile in the presence of a base, and in the last step the chiral auxiliary is displaced from the product of the following step by a nucleophile.

专利号:WO-0120995-A9
优先权日:1999-09-23
标题:Compounds directed against pilus biogenesis and activity in pathogenic bacteria; methods and compositions for synthesis thereof
发明人：KIHLBERG JAN; LARSSON ANDREAS; SVENSSON ANETTE; FEX TOMAS; HULTGREN SCOTT J; PINKNER JERRY
权利人:UNIV WASHINGTON; KIHLBERG JAN; LARSSON ANDREAS; SVENSSON ANETTE; FEX TOMAS; HULTGREN SCOTT J; PINKNER JERRY
摘要:Many Gram-negative pathogens assemble adhesive structures on their surfaces that allow them to colonize host tissues and cause disease. Novel compositions which inhibit or prevent the formation of a pilus chaperone-subunit complex are disclosed. Interfering with the function of the pili chaperone negatively affects the chaperone/usher pathway which is one molecular mechanism by which Gram-negative bacteria assemble adhesive pili structures and thus prevent or inhibit pilus assembly. Also provided are methods for the treatment or prevention of diseases caused by tissue-adhering pilus-forming bacteria by inhibiting the function of pilus chaperones. Also provided are pharmaceutical preparations capable of inhibiting or preventing the formation of a pilus chaperone-subunit complex. Also provided are methods of synthesizing the N-substituted amino acid compounds and compounds useful for the synthesis thereof. In particular, novel fluorinated linker compounds and methods of synthesis are provided. Methods for using the fluorinated linker compounds in methods of solid-phase synthesis of the N-substituted amino acid compounds are also disclosed.

专利号:US-6512137-B1
优先权日:1999-01-26
标题 :Synthesis method of nitroxymethylphenyl esters of aspirin derivatives
发明人：DEL SOLDATO PIERO; GARUFI MICHELE
权利人:NICOX SA
摘要:The invention describes a method for the synthesis of nitroxymethylphenyl esters of aspirin derivatives.