CAS: 80696-30-6; (R)-2-Aminopentan-1-Ol

相似化合物

2025376-01-4 22724-81-8 40918-51-2

上下游产品

CAS号2013-12-9 D-正缬氨酸 | CAS号4146-04-7 DL-2-氨基-1-戊醇 | CAS号62421-33-4 1-(4-methylphen...

📜D-正缬氨酸置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 作为反应溶剂,化学反应 2.0H,以63%的收率获得产物(R)-(-)-2-氨基-1-戊醇
参考文献:对映选择性合成和绝对构型的(-)-1-(苯并呋喃-2-基)-2-丙基氨基戊烷((-)-Bpap),一种高效的选择性儿茶酚胺能增强剂.
标题:对映选择性合成和绝对构型的(-)-1-(苯并呋喃-2-基)-2-丙基氨基戊烷((-)-Bpap),一种高效的选择性儿茶酚胺能增强剂.
摘要:描述了(-)-1-(苯并呋喃-2-基)-2-丙基氨基戊烷((-)-Bpap)的对映选择性合成和绝对构型,这是一种高效且选择性的儿茶酚胺能活性增强剂(cae)物质.合成方法包括苯并呋喃与(R)-N-甲苯磺酰基-2-丙基叠氮嗪或(R)-N-甲氧基-N-甲基降甲酰胺的偶联反应,然后对所得偶联产物进行适当的修饰.结果,(-)-Bpap证明具有r构型,其最终通过x射线晶体学分析得到证实.
DOI:10.1016/s0968-0896(00)00341-2

专利信息

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-2004106598-A1
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting Beta-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-2005192269-A1
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-2005267150-A1
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-6569851-B1
优先权日:1998-06-22
标 题 :Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds