CAS: 73575-55-0; 2,2',3,5,6'-Pentachlorobiphenyl
该化合物是多氯联苯(PCB)家族的成员,该家族由含有多氯原子的有机化合物组成,与联苯相关联,这种化合物通常表现出高度的疏水性,使其在水中不易溶解,但在有机溶剂中可溶解.其结构由两个苯环组成,由单一的联结组成,五个氯原子在环上的特定位置被替换,影响其化学反应和稳定性. 2,2,3,5,6,6欧元-苯以其在环境中的持久性和在活生物体中潜在的生物累积性为名,引起了人们对其毒性和生态影响的关切.由于这些特性,包括内分泌干扰和致癌性在内的各种不良健康影响.在许多国家,多氯联苯的使用受到严格管制或禁止.在环境样品中通常使用诸如气相色谱学-质谱仪等分析方法来检测和量化这种物质.
- 英文名称2,2',3,5,6'-Pentachlorobiphenyl
- 中文名称2,2',3,5,6'-五氯联苯
- IUPAC名称1,2,5-trichloro-3-(2,6-dichlorophenyl)benzene
- 其它别名2,2',3,5,6'-Pentachlorobiphenyl; 2,3,5,2',6'-Pentachlorobiphenyl; PCB 94
- CAS编号73575-55-0
- MFCD编号:MFCD00661148
- FDA UNII编号:RJK5TG98NC
- 分子式:C12H5Cl5分子量:326.43
- 产品CID: 1722988
- 产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: FJUVPPYNSDTRQV-UHFFFAOYSA-N
- 1S/C12H5Cl5/c13-6-4-7(12(17)10(16)5-6)11-8(14)2-1-3-9(11)15/h1-5H
- 计算化学: 氢键受体数*氢键供体数*可旋转键数1.0
MSDS等安全信息
- 危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website. - 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
上下游产品
1,3-dichloro-2-iodobenzene 1,2,5-trichloro-3-iodobenzene合成工艺路线路线简述
海关参考信息
- 2903911000-邻二氯苯
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合成参考文献
摘要:T14: Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold.
摘要:L4: ATSDR - Agency for Toxic Substances and Disease Registry (2000). Toxicological profile for polychlorinated biphenyls. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L134: ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
摘要:L135: International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
摘要:T6: World Health Organization (1993). Environ Health Criteria 140: Polychlorniated Biphenyls and Terphenyls.
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