CAS: 728-97-2; 2-((P-Tolyloxy)Methyl)Benzoic Acid

该化合物是一种合成有机化合物,其2位置为一种苯并酸核心,在2位置上被一个(4-甲基苯氧)甲基组替代为一种苯并酸核心.这一结构具有独特的物理化学特性,使其作为制药和农用化学合成的中间体具有价值.它的芳香和碳本酸功能能够使多种反应活动,包括酯化和恐吓,便于进一步的衍生.该化合物展示有机溶剂的中等溶性,加强其在反应系统中的效用.在标准条件下,其稳定性确保了可靠的处理和储存.其应用包括用于开发生物活性分子,使甲基苯氧混合物能够影响结合的相互作用.精密的合成和高纯度对于研究和工业过程中的一致性表现至关重要.

英文名称2-((P-Tolyloxy)Methyl)Benzoic Acid
中文名称2-((对甲苯氧基)甲基)苯甲酸
IUPAC名称2-((p-tolyloxy)methyl)benzoic acid
其它别名2-[(4-Methylphenoxy)Methyl]Benzoic Acid; Olopatadine Impurity 3; Benzoic Acid, 2-[(4-Methylphenoxy)Methyl]-; Olopatadine Impurity 16
CAS编号728-97-2
MFCD编号:MFCD00963955
分子式:C15H14O3分子量:242.27
产品CID: 2533044
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: WIXMNHDXMGVQOY-UHFFFAOYSA-N
InChI=1S/C15H14O3/c1-11-6-8-13(9-7-11)18-10-12-4-2-3-5-14(12)15(16)17/h2-9H,10H2,1H3,(H,16,17)
计算化学: 氢键受体数2.0氢键供体数1可旋转键数4

相似化合物

724-98-1 17819-91-9 244219-99-6

MSDS等安全信息

危险等级IRRITANT

上下游产品

methyl 2-bromomethylbenzoate 2-Methyl-benzoic acid methyl ester 2-benzofuran-1(3H)-one p-cresol 2-((4-methylphenoxy)methyl)benzoyl chloride ethyl 2-(4-methylphenoxymethyl)benzoate 2-((4-methylphenoxy)methyl)-N-((3-fluorophenyl)carbamothioyl)benzamide 2-((4-methylphenoxy)methyl)-N-((2,3,4-trifluorophenyl)carbamothioyl)benzamide

合成工艺路线路线简述

📜2-溴甲基苯甲酸甲酯置于sodium Hydroxide,Potassium Carbonate体系中,用四氢呋喃,甲醇,N,N-二甲基甲酰胺作为反应溶剂,化学反应 37.0H,反应生成 2-[(4-甲基苯氧基)甲基]苯甲酸
参考文献:4-Aminoquinolines: Novel Nociceptin Antagonists With Analgesic Activity
标题:4-Aminoquinolines: Novel Nociceptin Antagonists With Analgesic Activity
摘要:Small-Molecule Nociceptin Antagonists Were Synthesized To Examine Their Therapeutic Potential. After A 4-Aminoquinoline Derivative Was Found To Bind With The Human Orl1 Receptor,A Series Of 4-Aminoquinolines And Related Compounds Were Synthesized And Their Binding Was Evaluated. Elucidation Of Structure-Activity Relationships Eventually Led To The Optimum Compounds. One Of The Se Compounds,N-(4-Amino-2-Methylquinolin-6-yl)-2-(4-Ethylphenoxymethyl)Benzamide Hydrochloride (11) Not Only Antagonized Nociceptin-Induced Allodynia In Mice But Also Showed Analgesic Effect In A Hot Plate Test Using Mice And In A Formalin Test Using Rats. Its Analgesic Effect Was Not Antagonized By The Opioid Antagonist Naloxone. These Results Indicate That This Nociceptin Antagonist Has The Potential To Become A Novel Type Of Analgesic That Differs From Mu-Opioid Agonists.
DOI:10.1021/jm0002073