CAS: 646-01-5; 3-(Methylthio)Propionic Acid

该化合物是有机化合物,其特点是盒状酸功能组和甲基硫代亚替代组,其分子式包括碳,氢和硫原子,其结构反映了其作为丙酸衍生物的结构;该化合物一般是无色的,视其状态和纯度而定,可变成黄色的黄色液体或固体;该化合物在水和有机溶剂中溶解,使其具有多种用途;甲基硫酸组的存在具有独特的化学特性,影响其再活动性和潜在用途在有机合成中的用途,并成为制药和农用化学生产中的建筑块;此外,3-(甲基乙基硫)丙酸可能展示生物活动,使其对生物化学研究感兴趣;安全数据表明,与许多有机酸一样,应谨慎处理该化合物,以避免刺激或不良反应.

结构式图片

相似化合物

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合成工艺路线路线简述

    3-(甲硫基)丙腈置于盐酸体系中,化学反应 1.5H,反应生成 3-(甲基硫代)丙酸
    参考文献:Grue-Soerensen,Gunnar; Kelstrup,Ebbe; Kjaer,Anders,Journal Of The Chemical Society. Perkin Transactions I,1984,# 5,P. 1091-1097
    标题:Grue-Soerensen,Gunnar; Kelstrup,Ebbe; Kjaer,Anders,Journal Of The Chemical Society. Perkin Transactions I,1984,# 5,P. 1091-1097

    海关参考信息

    专利信息


    专利号:US-6608196-B2
    优先权日:2001-05-03
    标题 :Process for solid supported synthesis of pyruvate-derived compounds
    发明人:WANG BING; JANAGANI SATYANARAYANA; CALLAWAY WYETH B; SESSLER JONATHAN L
    权利人:GALILEO PHARMACEUTICALS INC
    摘要:Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.

    专利号:US-4661626-A
    优先权日:1985-03-11
    标题 :Process for the production of 2-isocyanato-2,3-dehydrocarboxylic acid esters
    发明人:EFFENBERGER FRANZ; KUEHLWEIN JUERGEN; DRAUZ KARLHEINZ
    权利人:DEGUSSA
    摘要:There are produced 2-isocyanato-2,3-dehydrocarboxylic acid esters of the general formula: (I) in which R1 is a straight chain or branched C1-C4-alkyl group, a phenyl group or a benzyl group, R2 is hydrogen or a methyl group and R3 is hydrogen, a straight chain or branched C1-C16-alkyl group, a C3-C8-cycloalkyl group, a C1-C6-alkylmercapto group or a phenyl group by reacting a 2-azido-carboxylic acid ester of the general formula: (II) in an inert solvent at a temperature between 0 DEG and 150 DEG C. with phosgene or diphosgene in the presence of a perrhenate. The compounds of general formula (I) can be converted into the corresponding Z- or BOC-protected 2,3-dehydro-2-amino-carboxylic acid ester with benzyl alcohol or with tert. butyl alcohol, which esters in turn are valuable building blocks for the synthesis of dehydropeptides.

    专利号:US-4454336-A
    优先权日:1982-09-27
    标题 :Derivatives of 3-(formylmethylthio)-propanoate
    发明人:CURRAN WILLIAM V; SASSIVER MARTIN L; BOOTHE JAMES H
    权利人:AMERICAN CYANAMID CO
    摘要:This disclosure describes a novel process for the synthesis of 5-mercapto-1,2,3-thiadiazoles which are useful as intermediates in the preparation of antibacterial agents.

    专利号:US-7390801-B2
    优先权日:1996-12-23
    标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
    发明人:THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
    权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
    摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

    专利号:US-9096873-B2
    优先权日:2008-03-11
    标题 :Adipate (ester or thioester) synthesis
    发明人:WU LIANG; TREFZER AXEL CHRISTOPH; DE WILDEMAN STEFAAN MARIE ANDRE; VAN DEN BERG MARCO ALEXANDER
    权利人:WU LIANG; TREFZER AXEL CHRISTOPH; DE WILDEMAN STEFAAN MARIE ANDRE; VAN DEN BERG MARCO ALEXANDER; GENOMATICA INC
    摘要:The present invention relates to a method for preparing an adipate ester or thioester. The invention further relates to a method for preparing adipic acid from said ester or thioester. Further the invention provides a number of methods for preparing an intermediate for said ester or thioester. Further the invention relates to a method for preparing 6-amino caproic acid (6-ACA), a method for preparing 5-formyl valeric acid (5-FVA), and a method for preparing caprolactam. Further, the invention relates to a host cell for use in a method according to the invention.

    专利号:EP-0104403-A1
    优先权日:1982-09-27
    标题 :New method for the synthesis of 5-thio-1,2,3-thiadiazole
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    主要参考文献

    [参考文献]: Kim Yc, Et Al. 3-Methylthiopropanoic Acid Produced By Enterobacter Intermedium 60-2G Inhibits Fungal Growth And Weed Seedling Development. J Antibiot (Tokyo). 2003 Feb;56(2):177-80.
    [参考文献]: Nakamura Y, Et Al. 3-Methylthiopropionic Acid Ethyl Ester, Isolated From Katsura-Uri (Japanese Pickling Melon, Cucumis Melo Var. Conomon), Enhanced Differentiation In Human Colon Cancer Cells. J Agric Food Chem. 2008 May 14;56(9):2977-84.
    [参考文献]: Steele Rd, Et Al. Identification Of 3-Methylthiopropionic Acid As An Intermediate In Mammalian Methioninemetabolism In Vitro. J Biol Chem. 1978 Nov 10;253(21):7844-50.
    [参考文献]: Surette R, Et Al. Formation Of 3-Methylthioacrylic Acid From Methionine By Streptomyces Lincolnensis. Isolation Of A Peroxidase. J Antibiot (Tokyo). 1976 Jun;29(6):646-52.

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