3-(甲硫基)丙腈置于盐酸体系中,化学反应 1.5H,反应生成 3-(甲基硫代)丙酸 参考文献:Grue-Soerensen,Gunnar; Kelstrup,Ebbe; Kjaer,Anders,Journal Of The Chemical Society. Perkin Transactions I,1984,# 5,P. 1091-1097 标题:Grue-Soerensen,Gunnar; Kelstrup,Ebbe; Kjaer,Anders,Journal Of The Chemical Society. Perkin Transactions I,1984,# 5,P. 1091-1097
专利号:US-6608196-B2 优先权日:2001-05-03 标题 :Process for solid supported synthesis of pyruvate-derived compounds 发明人:WANG BING; JANAGANI SATYANARAYANA; CALLAWAY WYETH B; SESSLER JONATHAN L 权利人:GALILEO PHARMACEUTICALS INC 摘要:Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.
专利号:US-4661626-A 优先权日:1985-03-11 标题 :Process for the production of 2-isocyanato-2,3-dehydrocarboxylic acid esters 发明人:EFFENBERGER FRANZ; KUEHLWEIN JUERGEN; DRAUZ KARLHEINZ 权利人:DEGUSSA 摘要:There are produced 2-isocyanato-2,3-dehydrocarboxylic acid esters of the general formula: (I) in which R1 is a straight chain or branched C1-C4-alkyl group, a phenyl group or a benzyl group, R2 is hydrogen or a methyl group and R3 is hydrogen, a straight chain or branched C1-C16-alkyl group, a C3-C8-cycloalkyl group, a C1-C6-alkylmercapto group or a phenyl group by reacting a 2-azido-carboxylic acid ester of the general formula: (II) in an inert solvent at a temperature between 0 DEG and 150 DEG C. with phosgene or diphosgene in the presence of a perrhenate. The compounds of general formula (I) can be converted into the corresponding Z- or BOC-protected 2,3-dehydro-2-amino-carboxylic acid ester with benzyl alcohol or with tert. butyl alcohol, which esters in turn are valuable building blocks for the synthesis of dehydropeptides.
专利号:US-4454336-A 优先权日:1982-09-27 标题 :Derivatives of 3-(formylmethylthio)-propanoate 发明人:CURRAN WILLIAM V; SASSIVER MARTIN L; BOOTHE JAMES H 权利人:AMERICAN CYANAMID CO 摘要:This disclosure describes a novel process for the synthesis of 5-mercapto-1,2,3-thiadiazoles which are useful as intermediates in the preparation of antibacterial agents.
专利号:US-7390801-B2 优先权日:1996-12-23 标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds 发明人:THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J 权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI 摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-9096873-B2 优先权日:2008-03-11 标题 :Adipate (ester or thioester) synthesis 发明人:WU LIANG; TREFZER AXEL CHRISTOPH; DE WILDEMAN STEFAAN MARIE ANDRE; VAN DEN BERG MARCO ALEXANDER 权利人:WU LIANG; TREFZER AXEL CHRISTOPH; DE WILDEMAN STEFAAN MARIE ANDRE; VAN DEN BERG MARCO ALEXANDER; GENOMATICA INC 摘要:The present invention relates to a method for preparing an adipate ester or thioester. The invention further relates to a method for preparing adipic acid from said ester or thioester. Further the invention provides a number of methods for preparing an intermediate for said ester or thioester. Further the invention relates to a method for preparing 6-amino caproic acid (6-ACA), a method for preparing 5-formyl valeric acid (5-FVA), and a method for preparing caprolactam. Further, the invention relates to a host cell for use in a method according to the invention.
专利号:EP-0104403-A1 优先权日:1982-09-27 标题 :New method for the synthesis of 5-thio-1,2,3-thiadiazole
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