N-Iminopyridinium Ylide置于氢碘酸体系中,用 乙醇 作为反应溶剂,化学反应生成 1-氨基吡啶碘 参考文献:Aminopyridinium Iodide As A Nh Transferring Agent For The Synthesis Of 2-Aroyl-3-Aryl Aziridines 标题:Aminopyridinium Iodide As A Nh Transferring Agent For The Synthesis Of 2-Aroyl-3-Aryl Aziridines 摘要:本文介绍了一种合成 N-H 酮吖啶的新方法.作为 Nh 转移剂的 1-Aminopyridinium Iodide 提供了从相应的 1,3-二异丙基-2-烯-1-酮直接获得 2-芳酰基-3-芳基氮丙啶的途径.提出了涉及 N-N Ylide 的可能一般机制. DOI:10.1007/s13738-015-0700-2
专利号:US-9265773-B2 优先权日:2011-09-08 标题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases 发明人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; HE SHUWEN; DAI XING; LIU HONG; LAI ZHONG; LONDON CLARE; XIAO DONG; ZORN NICOLAS; NARGUND RAVI 权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; HE SHUWEN; DAI XING; LIU HONG; LAI ZHONG; LONDON CLARE; XIAO DONG; ZORN NICOLAS; NARGUND RAVI; MERCK SHARP & DOHME; MSD ITALIA SRL 摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:US-9549917-B2 优先权日:2011-09-08 标 题 :Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases 发明人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; LAI ZHONG; DANG QUN; ZORN NICOLAS 权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; LAI ZHONG; DANG QUN; ZORN NICOLAS; MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:US-7585875-B2 优先权日:2006-06-06 标 题 :Substituted pyrazolo[1,5-a]pyridine compounds and their methods of use 发明人:GAETA FEDERICO C A; GROSS MATTHEW; JOHNSON KIRK W 权利人:AVIGEN INC 摘要:The present invention is directed to substituted pyrazolo[1,5-a]pyridines and related methods for their synthesis and use.
专利号:US-8518952-B2 优先权日:2008-08-06 标题 :6 substituted 2-heterocyclylamino pyrazine compounds as CHK-1 inhibitors 发明人:BRAGANZA JOHN FREDERICK; COLLINS MICHAEL RAYMOND; KATH JOHN CHARLES; NINKOVIC SACHA; LI HUI; RICHTER DANIEL TYLER 权利人:BRAGANZA JOHN FREDERICK; COLLINS MICHAEL RAYMOND; KATH JOHN CHARLES; NINKOVIC SACHA; LI HUI; RICHTER DANIEL TYLER; PFIZER 摘要:The present invention is directed to compounds of formula (I), n nand pharmaceutically acceptable salts thereof, their synthesis, and their use as CHK-1 inhibitors.
专利号:US-9115102-B2 优先权日:2009-09-17 标题 :N-[2-hydroxycarbamoyl-2-(piperazinyl) ethyl] benzamide compounds, their preparation and their use as TACE inhibitors 发明人:CHAMBON SANDRINE; CLARY LAURENCE; SCHUPPLI MARLENE 权利人:CHAMBON SANDRINE; CLARY LAURENCE; SCHUPPLI MARLENE; GALDERMA RES & DEV 摘要:The present invention relates to novel benzene-carboxamide compounds having a structure that corresponds to the general formula (I), and also to their method of synthesis and to their use in pharmaceutical compositions intended for use in human or veterinary medicine or else to their use in cosmetic compositions.
专利号:ES-2501640-T3 优先权日:2009-06-30 标题:Benzenesulfonamide compounds, their method of synthesis and their use in medicine