3-溴喹啉-1-氧化物置于甲醇,Palladium On Activated Charcoal,硫酸,Potassium Nitrate体系中,化学反应生成 5-氨基喹啉 参考文献:Okamoto,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1950,Vol. 70,P. 376,378 标题:Okamoto,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1950,Vol. 70,P. 376,378
专利号:US-2008171873-A1 优先权日:2007-01-12 标题:Synthesis of selected stereoisomers of certain substituted alcohols 发明人:HARMS ARTHUR E 权利人:HARMS ARTHUR E 摘要:A process for producing one selected stereoisomer of a substituted alcohol comprises reacting a stereoisomeric amine with a halogen-substituted heterocyclic compound, or a stereoisomeric ketone or aldehyde with an amino-substituted heterocyclic compound. The process avoids the production of a racemic mixture of stereoisomers of the prior art. Such a stereoisomeric substituted alcohol can be used for anti-inflammatory therapy.
专利号:US-2011137038-A1 优先权日:2006-11-09 标题 :Synthesis of selected stereoisomers of certain substituted alcohols 发明人:HARMS ARTHUR E 权利人:HARMS ARTHUR E 摘要:A process for producing one selected stereoisomer of a substituted alcohol comprises reacting a stereoisomeric epoxide with an amine, a carboxylic acid, an amide, a sulfonyl, or a cyanide. The process avoids the production of a racemic mixture of stereoisomers of the prior art. Such a stereoisomeric substituted alcohol can be used for anti-inflammatory therapy.
专利号:US-5656634-A 优先权日:1991-03-21 标题 :N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) 发明人:CHANG GEORGE; HAMANAKA ERNEST S; MCCARTHY PETER A; TRUONG THIEN V; WALKER FREDERICK J 权利人:PFIZER 摘要:Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R 1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
专利号:US-6531470-B1 优先权日:1998-01-23 标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:WO-2008088969-A2 优先权日:2007-01-12 标 题 :Synthesis of selected stereoisomers of certain substituted alcohols
专利号:US-2007060558-A1 优先权日:2004-07-30 标 题 :Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, the synthesis and uses thereof as antibacterial agents 发明人:SANCHEZ MURIEL; MEUNIER BERNARD 权利人:CENTRE NAT RECH SCIENT 摘要:The invention concerns an aminoquinoline-antibiotic hybrid compound of general formula (I): Q—(Y 1 ) p —(U) p —(Y 2 ) p -A: wherein Q represents an aminoquinoline, (Y 1 ) p (U) p —(Y 2 ) p″ is an optional spacer and A is an antibiotic residue. The invention enables the antibiotic residue activity to be unexpectedly enhanced.
[参考文献]: B G Siim, Et Al. Metabolic And Radiolytic Reduction Of 4-Alkylamino-5-Nitroquinoline Bioreductive Drugs. Relationship To Hypoxia-Selective Cytotoxicity. Biochem Pharmacol. 1994 Oct 18;48(8):1593-604. [参考文献]: Jagat P Bridhkoti, Et Al. Photochemistry Of 5-Aminoquinoline In Protic And Aprotic Solvents. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Aug;79(3):412-7. [参考文献]: V Arjunan, Et Al. Quantum Chemical And Spectroscopic Investigations Of 5-Aminoquinoline. Spectrochim Acta A Mol Biomol Spectrosc. 2009 Dec;74(5):1215-23. [参考文献]: Weston B Struwe, Et Al. Aminoquinolines As Fluorescent Labels For Hydrophilic Interaction Liquid Chromatography Of Oligosaccharides. Biol Chem. 2012 Aug;393(8):757-65.
合成参考文献
摘要:J. J. Elliott and S. F. Mason. J. Chem. Soc. 1959, 2352. 摘要:Hou, W.; Yang, G.; Xu, H., Science of Synthesis: DNA-Encoded Libraries, (2024) nan, 158.