专利号:US-8785656-B2 优先权日:2012-02-16 标 题:Telescoping synthesis of 5-amino-4-nitroso-1-alkyl-1H-pyrazole salt 发明人:GEIBEL WOLFRAM; WEBER INGO; OSAN ARMIN; SPECKBACHER MARKUS 权利人:PROCTER & GAMBLE 摘要:A telescoping synthesis of 5-amino-4-nitroso-1-alkyl-1H-pyrazole salt derivatives of formula (I), the compound (I) itself, and its use as an intermediate in the fabrication of 1-alkyl-4,5-diaminopyrazole salts of general formula (IX). The compounds of formula (IX) can be used as precursor dyes in oxidative hair dye compositions. n n n n n n n n n n R is a mono- or poly-substituted or unsubstituted, straight or branched, saturated or mono- or poly-unsaturated, alkyl group. HZ and HZ′ are organic or mineral acids.
专利号:US-4476252-A 优先权日:1982-11-06 标题 :Process for the synthesis of polymers with laterally linked polyoxyalkylene chains and their use for the production of polyurethanes 发明人:ESSELBORN EBERHARD; FOCK JUERGEN 权利人:GOLDSCHMIDT AG TH 摘要:Process for the synthesis of polymers with laterally linked polyoxyalkylene chains by the free radical polymerization of polyoxyalkylene ethers with olefinic double bonds with other vinyl compounds, capable of copolymerizing wherein the polyoxyalkylene ethers of allyl and/or methallyl alcohol are copolymerized in a known manner with vinyl esters of lower carboxylic acids or mixtures of vinyl esters of lower carboxylic acids with up to 50 mole percent of esters of acrylic or methacrylic acid. The compounds can be used to advantage as reaction components having hydroxyl groups in the production of polyurethanes. In particular, they improve the mechanical properties of polyurethane foams, such as, for example, their compression hardness.
专利号:US-7718833-B2 优先权日:2007-11-02 标 题:Purification of glycerin obtained as a bioproduct from the transesterification of triglycerides in the synthesis of biofuel 发明人:POTTHAST RAINER; CHUNG CHI PING; MATHUR INDRESH 权利人:JOHANN HALTERMANN LTD 摘要:Methods for purifying glycerin contaminated with one or more lower boiling alcohols such as methanol, ethanol, straight, branched or cyclic C3-C6 alcohols, and the like. The methods are particularly useful for purifying crude glycerin phases recovered from the synthesis of biofuels. The present invention uses distillation techniques to strip alcohol contaminants from glycerin. In contrast to conventional methods that carry out distillation either under substantially anhydrous or very wet conditions, the present invention carries out distillation in the presence of a limited amount of water, e.g., from about 0.8 to about 5 parts by weight of water per 100 parts by weight of contaminated glycerin to be purified.
专利号:US-8198465-B2 优先权日:2005-10-17 标 题 :3-alkyl-5- (4-alkyl-5-oxo-tetrahydrofutran-2-yl) pyrrolidin-2-one derivatives as intermediates in the synthesis of renin inhibitors 发明人:SEDELMEIER GOTTFRIED; GRIMLER DOMINIQUE; ACEMOGLU MURAT 权利人:SEDELMEIER GOTTFRIED; GRIMLER DOMINIQUE; ACEMOGLU MURAT; NOVARTIS AG 摘要:The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula II, n nor a salt thereof, and a compound of formula VIn n nor a salt thereof, wherein R 3 and R 4 as well as Act are as defined in the specification, and processes of manufacturing these.n n Additionally transformation of compounds (VI) with metallo organic compounds (VII) give rise to the new compounds (VIII) which are direct precursors for the preparation of Aliskiren.
专利号:US-7384739-B2 优先权日:2001-11-14 标题 :Compositions for enhancing DNA synthesis, DNA polymerase-related factors and utilization thereof 发明人:KITABAYASHI MASAO; KUROITA TOSHIHIRO; ISHIDA YOSHIKAZU; KOMATSUBARA HIDEYUKI; NISHIYA YOSHIAKI; OKA MASANORI; KAWAMURA YOSHIHISA; IMANAKA TADAYUKI 权利人:TOYO BOSEKI 摘要:The invention provides methods, kits, and compositions for enhancing synthesis of DNA involving a carboxylate ion-supplying substance that is effective in promoting DNA synthesis in enzymatic DNA synthesis reactions. The invention further provides a thermostable DNA polymerase-related factor derived from Thermococcus species, which has an activity to promote the DNA synthesis activity of DNA polymerase or which binds to DNA polymerase.
专利号:US-5384335-A 优先权日:1991-03-26 标 题:Methanol synthesis using a catalyst combination of alkali or alkaline earth salts and reduced copper chromite 发明人:TIERNEY JOHN W; WENDER IRVING; PALEKAR VISHWESH M 权利人:UNIV PITTSBURGH 摘要:The present invention relates to a novel route for the synthesis of methanol, and more specifically to the production of methanol by contacting synthesis gas under relatively mild conditions in a slurry phase with a catalyst combination comprising reduced copper chromite and basic alkali salts or alkaline earth salts. The present invention allows the synthesis of methanol to occur in the temperature range of approximately 100°-160° C. and the pressure range of 40-65 atm. The process produces methanol with up to 90% syngas conversion per pass and up to 95% methanol selectivity. The only major by-product is a small amount of easily separated methyl formate. Very small amounts of water, carbon dioxide and dimethyl ether are also produced. The present catalyst combination also is capable of tolerating fluctuations in the H 2 /CO ratio without major deleterious effect on the reaction rate. Furthermore, carbon dioxide and water are also tolerated without substantial catalyst deactivation.
摘要:Wu, X.; Xiao, J., Science of Synthesis: Water in Organic Synthesis, (2012) 1, 262. 摘要:Guram, A. S.; Milne, J. E.; Tedrow, J. S.; Walker, S. D., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 10. 摘要:Broggini, G.; Borsini, E.; Piarulli, U., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 539. 摘要:Whittlesey, M. K., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 290. 摘要:Li, Y.; Ding, K., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 1, 270.